ID   MED7A_XENLA             Reviewed;         228 AA.
AC   Q3B8I4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7-A;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 9-A;
DE            Short=CRSP complex subunit 9-A;
DE   AltName: Full=Mediator complex subunit 7-A;
GN   Name=med7-a; Synonyms=crsp9-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000305}.
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DR   EMBL; BC106352; AAI06353.1; -; mRNA.
DR   RefSeq; NP_001089696.1; NM_001096227.1.
DR   RefSeq; XP_018106737.1; XM_018251248.1.
DR   RefSeq; XP_018106739.1; XM_018251250.1.
DR   AlphaFoldDB; Q3B8I4; -.
DR   SMR; Q3B8I4; -.
DR   DNASU; 734758; -.
DR   GeneID; 734758; -.
DR   KEGG; xla:734758; -.
DR   CTD; 734758; -.
DR   Xenbase; XB-GENE-922723; med7.L.
DR   OrthoDB; 1356482at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 734758; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 6.10.140.200; -; 1.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   InterPro; IPR044888; Mediatior_Med7_sf.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..228
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   7-A"
FT                   /id="PRO_0000303182"
SQ   SEQUENCE   228 AA;  26299 MW;  BC1024F427A54161 CRC64;
     MGEPQQVSAL PIPPMQYIKE YTDENIRKSL APKPPVPIKD SYMMFGNQFQ CDDLIIRPLE
     TQGIERLHPV QFDHKKELRK LLMSILVNFL DMLDILIRSP GSIRREEKLE DLKLLFVHMH
     HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV VEMIQNCLAS LPDDLPLPDG
     TVSVKTEPMD VQEPCTDHHE GPQGAAASVK EATIDKDAAM CGIIDEMT