ID   MED7_CAEBR              Reviewed;         258 AA.
AC   Q60V43; A8XWI6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE   AltName: Full=Lethal protein 49;
DE   AltName: Full=Mediator complex subunit 7;
GN   Name=let-49; Synonyms=mdt-7; ORFNames=CBG19704;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000305}.
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DR   EMBL; HE601474; CAP37005.3; -; Genomic_DNA.
DR   RefSeq; XP_002640646.1; XM_002640600.1.
DR   STRING; 6238.CBG19704; -.
DR   EnsemblMetazoa; CBG19704.1; CBG19704.1; WBGene00038878.
DR   GeneID; 8582641; -.
DR   KEGG; cbr:CBG_19704; -.
DR   CTD; 8582641; -.
DR   WormBase; CBG19704; CBP04603; WBGene00038878; Cbr-let-49.
DR   eggNOG; KOG0570; Eukaryota.
DR   HOGENOM; CLU_065214_2_0_1; -.
DR   InParanoid; Q60V43; -.
DR   OMA; HTIFINM; -.
DR   OrthoDB; 1340410at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0000003; P:reproduction; IEA:EnsemblMetazoa.
DR   Gene3D; 6.10.140.200; -; 1.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   InterPro; IPR044888; Mediatior_Med7_sf.
DR   PANTHER; PTHR21428; PTHR21428; 1.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..258
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   7"
FT                   /id="PRO_0000303185"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  29529 MW;  5E299DEC1CD672C0 CRC64;
     MLPGFGATQT VSPFPNPPEY ASAYTSDRID NGSAPPPPHP LTEFKVFGEE YRLEEDVIAP
     LSTAGVEQYY VDKNNWKAEM KKLNRXIGAF FDLLEVLIRA PDHPARDKKM VDLHTIFINM
     HHLINEFRPV QARDSVRILQ ERQIDELTEI CDDFREYLAH GREVVEDQFK MITGKLPPPP
     PPSDLTRVRM QNGALHRLIE VEKETEEDEE MKEDDEEKPS TSSSEGNQKT LRDMTKGHGP
     PSVVNLLARQ LNEMELKK