ID   MED7_CRYNJ              Reviewed;         239 AA.
AC   P0CO76; Q55IA0; Q5K7T6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE   AltName: Full=Mediator complex subunit 7;
GN   Name=MED7; OrderedLocusNames=CNM01330;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000305}.
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DR   EMBL; AE017353; AAW46758.1; -; Genomic_DNA.
DR   RefSeq; XP_568275.1; XM_568275.1.
DR   AlphaFoldDB; P0CO76; -.
DR   SMR; P0CO76; -.
DR   STRING; 5207.AAW46758; -.
DR   PaxDb; P0CO76; -.
DR   EnsemblFungi; AAW46758; AAW46758; CNM01330.
DR   GeneID; 3255096; -.
DR   KEGG; cne:CNM01330; -.
DR   VEuPathDB; FungiDB:CNM01330; -.
DR   eggNOG; ENOG502SAJI; Eukaryota.
DR   HOGENOM; CLU_1120792_0_0_1; -.
DR   InParanoid; P0CO76; -.
DR   OMA; RERCESM; -.
DR   OrthoDB; 1356482at2759; -.
DR   Proteomes; UP000002149; Chromosome 13.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 6.10.140.200; -; 1.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   InterPro; IPR044888; Mediatior_Med7_sf.
DR   PANTHER; PTHR21428; PTHR21428; 1.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..239
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   7"
FT                   /id="PRO_0000303200"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   239 AA;  26889 MW;  B1FA4B08FF0F6FFB CRC64;
     MSSLPQEAAL PITNTLFPPP PPYFQAFTDE AIERYETLTG KSLFVNDEKG KTKGKEKKSD
     DRDMSVDIRI QDLTEEEQNE KLELEGKLEK PRADWVNEDG RWMCFGTMYT TEPIIPTAQS
     IGLPPFIDPA VEPQESLPPL LHSFLHTLLL LLDTLTMTAR TPNELAAAGW ASEGDQYIQH
     LTNLSANMMV ASNQLRSAQS EATLVLLMEK ELEERRKQTE KLRSKCKEIA SGIRALKGL