ID   MED7_DEBHA              Reviewed;         244 AA.
AC   Q6BKZ4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE   AltName: Full=Mediator complex subunit 7;
GN   Name=MED7; OrderedLocusNames=DEHA2F17644g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382138; CAG89510.2; -; Genomic_DNA.
DR   RefSeq; XP_461127.2; XM_461127.1.
DR   AlphaFoldDB; Q6BKZ4; -.
DR   SMR; Q6BKZ4; -.
DR   STRING; 4959.XP_461127.2; -.
DR   EnsemblFungi; CAG89510; CAG89510; DEHA2F17644g.
DR   GeneID; 2903678; -.
DR   KEGG; dha:DEHA2F17644g; -.
DR   VEuPathDB; FungiDB:DEHA2F17644g; -.
DR   eggNOG; KOG0570; Eukaryota.
DR   HOGENOM; CLU_065214_0_1_1; -.
DR   InParanoid; Q6BKZ4; -.
DR   OMA; PQHFDRR; -.
DR   OrthoDB; 1356482at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 6.10.140.200; -; 1.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   InterPro; IPR044888; Mediatior_Med7_sf.
DR   PANTHER; PTHR21428; PTHR21428; 1.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   7"
FT                   /id="PRO_0000303201"
SQ   SEQUENCE   244 AA;  28509 MW;  B37A2978A7FDA619 CRC64;
     MTSTNEDIIS SLYPPPPPYF KYFTEQNLNN LEIWKNKAQD EMQIDKTDLE QVKEDQDIKP
     PGELKFLVPP KQPDADHYRG FGNLWSFEDK LPGLKESGWT QLYKDDDELI TSNTKIDELH
     KLMDSLLLNF LELIGVVSID PQQFHYKIED LKLILININH ILNTYRPHQS RESLIMLLRK
     QIDMKRNEIS EIDKTSEDIK SKILKLVDTS YIGDQEDAKC DNDSTEDEES IKNNIIQKLL
     NQNV