MED7_DICDI
ID MED7_DICDI Reviewed; 345 AA.
AC Q55DQ5;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Putative mediator of RNA polymerase II transcription subunit 7;
DE AltName: Full=Putative mediator complex subunit 7;
GN Name=med7; ORFNames=DDB_G0269568;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=18515835; DOI=10.1093/nar/gkn349;
RA Bourbon H.-M.;
RT "Comparative genomics supports a deep evolutionary origin for the large,
RT four-module transcriptional mediator complex.";
RL Nucleic Acids Res. 36:3993-4008(2008).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72134.1; -; Genomic_DNA.
DR RefSeq; XP_646076.1; XM_640984.1.
DR AlphaFoldDB; Q55DQ5; -.
DR SMR; Q55DQ5; -.
DR STRING; 44689.DDB0266857; -.
DR PaxDb; Q55DQ5; -.
DR EnsemblProtists; EAL72134; EAL72134; DDB_G0269568.
DR GeneID; 8617026; -.
DR KEGG; ddi:DDB_G0269568; -.
DR dictyBase; DDB_G0269568; med7.
DR eggNOG; KOG0570; Eukaryota.
DR HOGENOM; CLU_805171_0_0_1; -.
DR InParanoid; Q55DQ5; -.
DR OMA; SYRPHQA; -.
DR PRO; PR:Q55DQ5; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0070847; C:core mediator complex; ISS:dictyBase.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:dictyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 6.10.140.200; -; 1.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR009244; Mediatior_Med7.
DR InterPro; IPR044888; Mediatior_Med7_sf.
DR PANTHER; PTHR21428; PTHR21428; 1.
DR Pfam; PF05983; Med7; 1.
DR SUPFAM; SSF140718; SSF140718; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..345
FT /note="Putative mediator of RNA polymerase II transcription
FT subunit 7"
FT /id="PRO_0000388647"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 39699 MW; ED9FC7FA9EB5FE4A CRC64;
MNTSQQQQQQ QQQQQQQQQQ QQQTPQQVEN VSAFPPPPPF YKLYLNYKKD VDYSKPTTEN
SKKNDTPEGN ESTIEKNIDN SDEMNIDNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNKATT STNKKIELNK PLAPPLPPKV GANYVQFGQT YSTVDMLPSL DESGAKQLYP
KGDIEPISEL KKLNRSILFN YLQLLETLIE NPKNYQSKIE DISLLFINFH HLLNSYRPHQ
ARETLLSIMN EQIKQKNQSN ESIKKALDIC KESLMNSFKN LNIEDKQIDS ATPLPTNITS
PTKNLMSPTK LNNSQDVNMN ENNDDDEDKE INWMDQLLDE MLKIN
