ID   MED7_NEUCR              Reviewed;         347 AA.
AC   Q7S2D4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE   AltName: Full=Mediator complex subunit 7;
GN   Name=med-7; ORFNames=NCU05944;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000305}.
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DR   EMBL; CM002241; EAA29552.1; -; Genomic_DNA.
DR   RefSeq; XP_958788.1; XM_953695.2.
DR   AlphaFoldDB; Q7S2D4; -.
DR   SMR; Q7S2D4; -.
DR   STRING; 5141.EFNCRP00000001609; -.
DR   EnsemblFungi; EAA29552; EAA29552; NCU05944.
DR   GeneID; 3874935; -.
DR   KEGG; ncr:NCU05944; -.
DR   VEuPathDB; FungiDB:NCU05944; -.
DR   HOGENOM; CLU_065214_0_1_1; -.
DR   InParanoid; Q7S2D4; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 6.10.140.200; -; 1.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   InterPro; IPR044888; Mediatior_Med7_sf.
DR   PANTHER; PTHR21428; PTHR21428; 1.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   7"
FT                   /id="PRO_0000303205"
FT   REGION          97..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  37117 MW;  B97EAC89905B990F CRC64;
     MADTEDDNSA LASFFPDPPL FWKAFTPSNL QAYAEIKQQY ASQHGIPVED VVRVPDLPAD
     SDLIYLQPPA EPKDGTWRLY GEPQSLEESL QPLESAGIER LGPPLPGSTT TSTSNTQTTT
     TDSQSTTQPT TDDTQPTSAF PSQQPTSQLP LPPSSTSAPG GASSGASSTQ THDTLHLHLK
     RLSKSLLLNF LELLGIMSLD PAAGSQKAAD LRTLFLNFHH VLNEYRPHQA REQLIQLMQE
     RLDQTRAETA ANRAVAEKAR RVLEGLGSVE IPAVDDVNIA GTGTGGGDGE AGYGSAAVPV
     PVPVGARTGT TVGDRRVGVD GEGAEEEEKM YWEREGMGWG VLDAEFA