MED7_PICST
ID MED7_PICST Reviewed; 257 AA.
AC A3LZW1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE AltName: Full=Mediator complex subunit 7;
GN Name=MED7; ORFNames=PICST_66143;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC {ECO:0000305}.
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DR EMBL; CP000502; ABN68608.2; -; Genomic_DNA.
DR RefSeq; XP_001386637.2; XM_001386600.1.
DR AlphaFoldDB; A3LZW1; -.
DR SMR; A3LZW1; -.
DR STRING; 4924.XP_001386637.2; -.
DR EnsemblFungi; ABN68608; ABN68608; PICST_66143.
DR GeneID; 4840876; -.
DR KEGG; pic:PICST_66143; -.
DR eggNOG; KOG0570; Eukaryota.
DR HOGENOM; CLU_065214_0_1_1; -.
DR InParanoid; A3LZW1; -.
DR OMA; PQHFDRR; -.
DR OrthoDB; 1356482at2759; -.
DR Proteomes; UP000002258; Chromosome 8.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.140.200; -; 1.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR009244; Mediatior_Med7.
DR InterPro; IPR044888; Mediatior_Med7_sf.
DR PANTHER; PTHR21428; PTHR21428; 1.
DR Pfam; PF05983; Med7; 1.
DR SUPFAM; SSF140718; SSF140718; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..257
FT /note="Mediator of RNA polymerase II transcription subunit
FT 7"
FT /id="PRO_0000303207"
FT REGION 33..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 29653 MW; 8C7D5BD62DFBA874 CRC64;
MSTANGDLIS SLYPPPPVYV KFFTTENLNK LQEWQRQQND EEIETKQEEA DDKDEKDNEK
QNETQDTVPP GELRFLVPPQ PPSGTHYRGY GNIWSFEDKL PSLKSANWEQ LYKDDDESIT
SETKIKELHK LMDSLLLNFL ELIGLASIDP SQYESKIKDI SLILININHL LNTYRPHQSR
ESLIMLLRKQ IDAKRASINQ VEKVCSEVKQ KLLKLTNIQD VYKKDSIVLP DNSDNSPMAE
NAESIKDEII KKLLSEH
