MED7_PIG
ID MED7_PIG Reviewed; 233 AA.
AC Q2F7Z4; Q2F7Z6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 9;
DE Short=CRSP complex subunit 9;
DE AltName: Full=Mediator complex subunit 7;
GN Name=MED7; Synonyms=CRSP9;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=16484800; DOI=10.1159/000089899;
RA Shao M.Y., Wang H., Zhu Z.M., Yang S.L., Li K.;
RT "Assignment of CRSP9, ETF1 and TMEM59 genes to porcine chromosomes.";
RL Cytogenet. Genome Res. 112:342I-342I(2006).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC {ECO:0000305}.
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DR EMBL; DQ200861; ABB02674.1; -; Genomic_DNA.
DR EMBL; DQ200863; ABB02676.1; -; mRNA.
DR RefSeq; NP_001038080.1; NM_001044615.1.
DR RefSeq; XP_005672641.1; XM_005672584.2.
DR RefSeq; XP_005672642.1; XM_005672585.2.
DR RefSeq; XP_005672643.1; XM_005672586.2.
DR RefSeq; XP_005672644.1; XM_005672587.2.
DR AlphaFoldDB; Q2F7Z4; -.
DR SMR; Q2F7Z4; -.
DR STRING; 9823.ENSSSCP00000018072; -.
DR PaxDb; Q2F7Z4; -.
DR Ensembl; ENSSSCT00000018572; ENSSSCP00000018072; ENSSSCG00000017058.
DR Ensembl; ENSSSCT00000068622; ENSSSCP00000067996; ENSSSCG00000017058.
DR Ensembl; ENSSSCT00000068927; ENSSSCP00000074390; ENSSSCG00000017058.
DR Ensembl; ENSSSCT00000072169; ENSSSCP00000069715; ENSSSCG00000017058.
DR Ensembl; ENSSSCT00000078443; ENSSSCP00000060392; ENSSSCG00000017058.
DR Ensembl; ENSSSCT00000087107; ENSSSCP00000070953; ENSSSCG00000017058.
DR Ensembl; ENSSSCT00005058163; ENSSSCP00005035907; ENSSSCG00005036433.
DR Ensembl; ENSSSCT00005058186; ENSSSCP00005035922; ENSSSCG00005036433.
DR Ensembl; ENSSSCT00005058191; ENSSSCP00005035924; ENSSSCG00005036433.
DR Ensembl; ENSSSCT00005058195; ENSSSCP00005035927; ENSSSCG00005036433.
DR Ensembl; ENSSSCT00005058201; ENSSSCP00005035929; ENSSSCG00005036433.
DR Ensembl; ENSSSCT00005058204; ENSSSCP00005035931; ENSSSCG00005036433.
DR Ensembl; ENSSSCT00015007794; ENSSSCP00015003154; ENSSSCG00015005855.
DR Ensembl; ENSSSCT00015007824; ENSSSCP00015003170; ENSSSCG00015005855.
DR Ensembl; ENSSSCT00015007841; ENSSSCP00015003173; ENSSSCG00015005855.
DR Ensembl; ENSSSCT00015007847; ENSSSCP00015003175; ENSSSCG00015005855.
DR Ensembl; ENSSSCT00015007851; ENSSSCP00015003177; ENSSSCG00015005855.
DR Ensembl; ENSSSCT00025038954; ENSSSCP00025016480; ENSSSCG00025028703.
DR Ensembl; ENSSSCT00025039051; ENSSSCP00025016524; ENSSSCG00025028703.
DR Ensembl; ENSSSCT00025039107; ENSSSCP00025016550; ENSSSCG00025028703.
DR Ensembl; ENSSSCT00025039130; ENSSSCP00025016561; ENSSSCG00025028703.
DR Ensembl; ENSSSCT00025039175; ENSSSCP00025016582; ENSSSCG00025028703.
DR Ensembl; ENSSSCT00025039190; ENSSSCP00025016589; ENSSSCG00025028703.
DR Ensembl; ENSSSCT00030020331; ENSSSCP00030009062; ENSSSCG00030014759.
DR Ensembl; ENSSSCT00030020337; ENSSSCP00030009063; ENSSSCG00030014759.
DR Ensembl; ENSSSCT00030020345; ENSSSCP00030009067; ENSSSCG00030014759.
DR Ensembl; ENSSSCT00030020355; ENSSSCP00030009071; ENSSSCG00030014759.
DR Ensembl; ENSSSCT00030020364; ENSSSCP00030009076; ENSSSCG00030014759.
DR Ensembl; ENSSSCT00030020376; ENSSSCP00030009083; ENSSSCG00030014759.
DR Ensembl; ENSSSCT00035066123; ENSSSCP00035026823; ENSSSCG00035049608.
DR Ensembl; ENSSSCT00035066129; ENSSSCP00035026826; ENSSSCG00035049608.
DR Ensembl; ENSSSCT00035066131; ENSSSCP00035026827; ENSSSCG00035049608.
DR Ensembl; ENSSSCT00035066134; ENSSSCP00035026829; ENSSSCG00035049608.
DR Ensembl; ENSSSCT00035066136; ENSSSCP00035026830; ENSSSCG00035049608.
DR Ensembl; ENSSSCT00040063580; ENSSSCP00040026848; ENSSSCG00040047209.
DR Ensembl; ENSSSCT00040063632; ENSSSCP00040026874; ENSSSCG00040047209.
DR Ensembl; ENSSSCT00040063657; ENSSSCP00040026883; ENSSSCG00040047209.
DR Ensembl; ENSSSCT00040063760; ENSSSCP00040026925; ENSSSCG00040047209.
DR Ensembl; ENSSSCT00040063793; ENSSSCP00040026941; ENSSSCG00040047209.
DR Ensembl; ENSSSCT00045013336; ENSSSCP00045009196; ENSSSCG00045007956.
DR Ensembl; ENSSSCT00045013361; ENSSSCP00045009214; ENSSSCG00045007956.
DR Ensembl; ENSSSCT00045013376; ENSSSCP00045009225; ENSSSCG00045007956.
DR Ensembl; ENSSSCT00045013394; ENSSSCP00045009240; ENSSSCG00045007956.
DR Ensembl; ENSSSCT00045013407; ENSSSCP00045009250; ENSSSCG00045007956.
DR Ensembl; ENSSSCT00050041688; ENSSSCP00050017224; ENSSSCG00050031016.
DR Ensembl; ENSSSCT00050041694; ENSSSCP00050017226; ENSSSCG00050031016.
DR Ensembl; ENSSSCT00050041699; ENSSSCP00050017228; ENSSSCG00050031016.
DR Ensembl; ENSSSCT00050041704; ENSSSCP00050017232; ENSSSCG00050031016.
DR Ensembl; ENSSSCT00050041707; ENSSSCP00050017234; ENSSSCG00050031016.
DR Ensembl; ENSSSCT00050041713; ENSSSCP00050017240; ENSSSCG00050031016.
DR Ensembl; ENSSSCT00055013659; ENSSSCP00055010755; ENSSSCG00055007049.
DR Ensembl; ENSSSCT00055013696; ENSSSCP00055010783; ENSSSCG00055007049.
DR Ensembl; ENSSSCT00055013718; ENSSSCP00055010798; ENSSSCG00055007049.
DR Ensembl; ENSSSCT00055013737; ENSSSCP00055010814; ENSSSCG00055007049.
DR Ensembl; ENSSSCT00055013748; ENSSSCP00055010824; ENSSSCG00055007049.
DR Ensembl; ENSSSCT00055013757; ENSSSCP00055010833; ENSSSCG00055007049.
DR Ensembl; ENSSSCT00060027098; ENSSSCP00060011546; ENSSSCG00060020044.
DR Ensembl; ENSSSCT00060027099; ENSSSCP00060011547; ENSSSCG00060020044.
DR Ensembl; ENSSSCT00060027100; ENSSSCP00060011548; ENSSSCG00060020044.
DR Ensembl; ENSSSCT00060027104; ENSSSCP00060011550; ENSSSCG00060020044.
DR Ensembl; ENSSSCT00060027107; ENSSSCP00060011551; ENSSSCG00060020044.
DR Ensembl; ENSSSCT00060027109; ENSSSCP00060011552; ENSSSCG00060020044.
DR Ensembl; ENSSSCT00065068071; ENSSSCP00065029638; ENSSSCG00065049702.
DR Ensembl; ENSSSCT00065068076; ENSSSCP00065029642; ENSSSCG00065049702.
DR Ensembl; ENSSSCT00065068078; ENSSSCP00065029644; ENSSSCG00065049702.
DR Ensembl; ENSSSCT00065068086; ENSSSCP00065029647; ENSSSCG00065049702.
DR Ensembl; ENSSSCT00065068090; ENSSSCP00065029648; ENSSSCG00065049702.
DR Ensembl; ENSSSCT00065068091; ENSSSCP00065029649; ENSSSCG00065049702.
DR GeneID; 733689; -.
DR KEGG; ssc:733689; -.
DR CTD; 9443; -.
DR VGNC; VGNC:90123; MED7.
DR eggNOG; KOG0570; Eukaryota.
DR GeneTree; ENSGT00940000154444; -.
DR HOGENOM; CLU_065214_2_0_1; -.
DR InParanoid; Q2F7Z4; -.
DR OMA; PQHFDRR; -.
DR OrthoDB; 1356482at2759; -.
DR TreeFam; TF314411; -.
DR Reactome; R-SSC-212436; Generic Transcription Pathway.
DR Proteomes; UP000008227; Chromosome 16.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000017058; Expressed in oocyte and 45 other tissues.
DR ExpressionAtlas; Q2F7Z4; baseline and differential.
DR Genevisible; Q2F7Z4; SS.
DR GO; GO:0070847; C:core mediator complex; IEA:Ensembl.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR Gene3D; 6.10.140.200; -; 1.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR009244; Mediatior_Med7.
DR InterPro; IPR044888; Mediatior_Med7_sf.
DR Pfam; PF05983; Med7; 1.
DR SUPFAM; SSF140718; SSF140718; 1.
PE 2: Evidence at transcript level;
KW Activator; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..233
FT /note="Mediator of RNA polymerase II transcription subunit
FT 7"
FT /id="PRO_0000303180"
FT REGION 188..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43513"
FT CROSSLNK 185
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1); alternate"
FT /evidence="ECO:0000250|UniProtKB:O43513"
FT CROSSLNK 185
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:O43513"
FT CONFLICT 179
FT /note="E -> V (in Ref. 1; ABB02676)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 233 AA; 27165 MW; 425106E8360B84E3 CRC64;
MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ CDDLIIRPLE
SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP GSIKREEKLE DLKLLFVHVH
HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV IEMIQNCLAS LPDDLPHSEA
GMRVKAEPMD ADDSNNCTGQ SDQQRENSGH RRDQIIEKDA ALCVLIDEMN ERP
