ID   MED7_USTMA              Reviewed;         315 AA.
AC   Q4P2Y1; A0A0D1DQ51;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE   AltName: Full=Mediator complex subunit 7;
GN   Name=MED7; ORFNames=UMAG_12306;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000305}.
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DR   EMBL; CM003157; KIS66539.1; -; Genomic_DNA.
DR   RefSeq; XP_011391967.1; XM_011393665.1.
DR   AlphaFoldDB; Q4P2Y1; -.
DR   SMR; Q4P2Y1; -.
DR   STRING; 5270.UM05532P0; -.
DR   EnsemblFungi; KIS66539; KIS66539; UMAG_12306.
DR   GeneID; 23568051; -.
DR   KEGG; uma:UMAG_12306; -.
DR   VEuPathDB; FungiDB:UMAG_12306; -.
DR   eggNOG; ENOG502SAJI; Eukaryota.
DR   HOGENOM; CLU_065214_1_0_1; -.
DR   InParanoid; Q4P2Y1; -.
DR   OrthoDB; 1356482at2759; -.
DR   Proteomes; UP000000561; Chromosome 18.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 6.10.140.200; -; 1.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   InterPro; IPR044888; Mediatior_Med7_sf.
DR   PANTHER; PTHR21428; PTHR21428; 1.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..315
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   7"
FT                   /id="PRO_0000303208"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   315 AA;  36077 MW;  FF8A44F4008201BC CRC64;
     MNGEYDYEDG AQHQDGARES AVAGASNTNQ ISTSFFPPPP QVYKKFTKRN LRYLEILNSH
     KLADDEPSWD LLSVTQRLER QNAILRQPGS SSKIDAEQLQ DEEADMAAIQ DQDCDKPMTD
     LPDFDLKAEL EPPNVDWIEE DGGYTVFGQL WPIPDVTPTL QQLGIPVLYP LEGTDRKELL
     LTLLRTLLQT YREITGDLLK PAQPYDVWVP AVPDPNLTPE QQQQQMATNP GFWTQTTEAK
     DRLKHMQNVV VNMQFLINEL RPVQAKETLK LIMQMQLERR KQEMQLIQER CATMRARVEE
     LKKMLGKQSD CYGSS