MED7_XENTR
ID MED7_XENTR Reviewed; 229 AA.
AC Q5BJ48;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 9;
DE Short=CRSP complex subunit 9;
DE AltName: Full=Mediator complex subunit 7;
GN Name=med7; Synonyms=crsp9; ORFNames=TGas067f23.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC {ECO:0000305}.
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DR EMBL; CR848598; CAJ83895.1; -; mRNA.
DR EMBL; BC091623; AAH91623.1; -; mRNA.
DR RefSeq; NP_001016879.1; NM_001016879.2.
DR RefSeq; XP_012814505.1; XM_012959051.2.
DR AlphaFoldDB; Q5BJ48; -.
DR SMR; Q5BJ48; -.
DR STRING; 8364.ENSXETP00000003150; -.
DR PaxDb; Q5BJ48; -.
DR Ensembl; ENSXETT00000003150; ENSXETP00000003150; ENSXETG00000001505.
DR GeneID; 549633; -.
DR KEGG; xtr:549633; -.
DR CTD; 9443; -.
DR Xenbase; XB-GENE-922711; med7.
DR eggNOG; KOG0570; Eukaryota.
DR HOGENOM; CLU_065214_2_0_1; -.
DR InParanoid; Q5BJ48; -.
DR OMA; HTIFINM; -.
DR OrthoDB; 1356482at2759; -.
DR PhylomeDB; Q5BJ48; -.
DR TreeFam; TF314411; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000001505; Expressed in egg cell and 13 other tissues.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 6.10.140.200; -; 1.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR009244; Mediatior_Med7.
DR InterPro; IPR044888; Mediatior_Med7_sf.
DR Pfam; PF05983; Med7; 1.
DR SUPFAM; SSF140718; SSF140718; 1.
PE 2: Evidence at transcript level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..229
FT /note="Mediator of RNA polymerase II transcription subunit
FT 7"
FT /id="PRO_0000303184"
SQ SEQUENCE 229 AA; 26474 MW; F5AB5D680B1A6500 CRC64;
MGEPQQVSAL PIPPMQYIKE YTDENIRKGL APKPPLPIKD SYMMFGNQFQ CDDLIIRPLE
TQGIERLHPM QFDHKKELRK LLMSILVNFL DMLDILIRSP GSIRREEKLE DLKLLFVHMH
HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV VEMIQNCLAS LPNDLPLSDG
AVSVKTEPMD VREPCTDHHA GPQEAAAASL KETTIDKDAA MCVIIDEMT
