ID   ARHG6_CHICK             Reviewed;         764 AA.
AC   Q5ZLR6;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Rho guanine nucleotide exchange factor 6;
DE   AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6;
GN   Name=ARHGEF6; ORFNames=RCJMB04_5b15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250}.
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DR   EMBL; AJ719668; CAG31327.1; -; mRNA.
DR   RefSeq; NP_001006432.1; NM_001006432.1.
DR   AlphaFoldDB; Q5ZLR6; -.
DR   SMR; Q5ZLR6; -.
DR   IntAct; Q5ZLR6; 2.
DR   MINT; Q5ZLR6; -.
DR   STRING; 9031.ENSGALP00000010376; -.
DR   PaxDb; Q5ZLR6; -.
DR   GeneID; 422247; -.
DR   KEGG; gga:422247; -.
DR   CTD; 9459; -.
DR   VEuPathDB; HostDB:geneid_422247; -.
DR   eggNOG; KOG2070; Eukaryota.
DR   HOGENOM; CLU_017010_1_1_1; -.
DR   InParanoid; Q5ZLR6; -.
DR   PhylomeDB; Q5ZLR6; -.
DR   PRO; PR:Q5ZLR6; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030027; C:lamellipodium; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0030032; P:lamellipodium assembly; IBA:GO_Central.
DR   CDD; cd00014; CH; 1.
DR   CDD; cd01225; PH_Cool_Pix; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd12060; SH3_alphaPIX; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035788; AlphaPIX_SH3.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR032409; GEF6/7_CC.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR046376; PH_Cool_Pix.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF16523; betaPIX_CC; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Guanine-nucleotide releasing factor; Reference proteome;
KW   SH3 domain.
FT   CHAIN           1..764
FT                   /note="Rho guanine nucleotide exchange factor 6"
FT                   /id="PRO_0000080920"
FT   DOMAIN          1..110
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   DOMAIN          152..211
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          233..413
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          435..540
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          109..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   764 AA;  85908 MW;  3DF41DBE90259847 CRC64;
     MNPEEQVVTW LISLGVLNSP KKIVDDPEEF LKTSLKDGTV LCKLIHRLLP GSAEKYCLEP
     KNEADCISNI QEFLRGCAVL KVELFEPHDL YSGEQFSKVL STLTAVNKAT EDQPSEGPCS
     HPSALSSAAG GAHTDSNSTA SQSAKEMTEN GSHQLVVKAR FNFKQTNEDE LSVNKGDIIY
     VTRVEEGGWW EGTLNGKTGW FPSNYVREIK STDKPLSPKA LKGLESTQLT KNYYPVVLQN
     ILETERDYAK ELQSLLGTYL RPLQSYDKLS AVDIASLLGN VEEISAFQQT LNQALEDVAK
     LPENQQRVGG CFMNLMAQFR SLYLTYCANH PSAVSVLTQH SDELEKFMES QGAANPGILI
     LTTSLSKPFL RLDKYVTLLQ ELERHMEEAH ADHEDVLKAI TSFKSLVSQC QELRKRKQLE
     LQILSESIQR WEGEDIKTMG NIIYMSQVMV QSGGSEEKEE RYFLLFSNVL LMLSASPRMS
     GFIYQGRLPL TGMTLTKLED AEGNEHMFEI AGNMMERITV SCSTSQDLHE WLEHLQRLTK
     GTCNTVSKTQ SWSAHSTFGS TGQIRGPLEP PKILKPWSLS CLRPAPPLRP SAALSYKERM
     SYILKDSSKS PKTMKKFLPK RKTERKASDE EFVIRKSTAA LEEDAQILKV IEAYCTGAGF
     QQALSSGSRK DSIPQVLLPE EEKIIIEETR SNGQTVTEEK SLVDTVYALK DEVKELKQEN
     KRMKQCLEEE LKSRKDLEKL VRRLLKQTDE CSREETGRKS SLIA