位置:首页 > 蛋白库 > MED8_SCHPO
MED8_SCHPO
ID   MED8_SCHPO              Reviewed;         200 AA.
AC   O94646;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 137.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 8;
DE   AltName: Full=Cell separation protein sep15;
DE   AltName: Full=Mediator complex subunit 8;
GN   Name=med8; Synonyms=sep15; ORFNames=SPBC21.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11191205; DOI=10.1007/s002940000158;
RA   Zilahi E., Miklos I., Sipiczki M.;
RT   "The Schizosaccharomyces pombe sep15+ gene encodes a protein homologous to
RT   the Med8 subunit of the Saccharomyces cerevisiae transcriptional mediator
RT   complex.";
RL   Curr. Genet. 38:227-232(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE MEDIATOR
RP   COMPLEX.
RX   PubMed=11572939; DOI=10.1073/pnas.211253898;
RA   Spaehr H., Samuelsen C.O., Baraznenok V., Ernest I., Huylebroeck D.,
RA   Remacle J.E., Samuelsson T., Kieselbach T., Holmberg S., Gustafsson C.M.;
RT   "Analysis of Schizosaccharomyces pombe mediator reveals a set of essential
RT   subunits conserved between yeast and metazoan cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:11985-11990(2001).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000269|PubMed:11572939}.
CC   -!- INTERACTION:
CC       O94646; O74825: rpb4; NbExp=3; IntAct=EBI-1533413, EBI-697320;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 8 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF093755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU329671; CAB36884.1; -; Genomic_DNA.
DR   PIR; T39886; T39886.
DR   RefSeq; NP_596338.1; NM_001022259.2.
DR   PDB; 3C0T; X-ray; 2.40 A; B=180-200.
DR   PDB; 4H63; X-ray; 3.40 A; H=1-200.
DR   PDB; 5N9J; X-ray; 3.40 A; U=1-200.
DR   PDB; 5U0P; EM; 4.40 A; H=1-200.
DR   PDB; 5U0S; EM; 7.80 A; H=1-200.
DR   PDBsum; 3C0T; -.
DR   PDBsum; 4H63; -.
DR   PDBsum; 5N9J; -.
DR   PDBsum; 5U0P; -.
DR   PDBsum; 5U0S; -.
DR   AlphaFoldDB; O94646; -.
DR   SMR; O94646; -.
DR   BioGRID; 277281; 15.
DR   DIP; DIP-38755N; -.
DR   IntAct; O94646; 5.
DR   MINT; O94646; -.
DR   STRING; 4896.SPBC21.04.1; -.
DR   MaxQB; O94646; -.
DR   PaxDb; O94646; -.
DR   EnsemblFungi; SPBC21.04.1; SPBC21.04.1:pep; SPBC21.04.
DR   GeneID; 2540761; -.
DR   KEGG; spo:SPBC21.04; -.
DR   PomBase; SPBC21.04; med8.
DR   VEuPathDB; FungiDB:SPBC21.04; -.
DR   eggNOG; ENOG502S8U1; Eukaryota.
DR   HOGENOM; CLU_108151_0_0_1; -.
DR   InParanoid; O94646; -.
DR   OMA; PQWYSLQ; -.
DR   PhylomeDB; O94646; -.
DR   EvolutionaryTrace; O94646; -.
DR   PRO; PR:O94646; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0016592; C:mediator complex; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IDA:PomBase.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IC:PomBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019364; Mediatior_Med8_fun/met.
DR   PANTHER; PTHR13074; PTHR13074; 1.
DR   Pfam; PF10232; Med8; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..200
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   8"
FT                   /id="PRO_0000096396"
FT   HELIX           4..37
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   HELIX           43..66
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   HELIX           68..72
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   STRAND          74..78
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   TURN            84..86
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   HELIX           88..94
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   HELIX           101..117
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   HELIX           130..147
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   HELIX           148..150
FT                   /evidence="ECO:0007829|PDB:4H63"
FT   STRAND          154..157
FT                   /evidence="ECO:0007829|PDB:5N9J"
FT   HELIX           160..165
FT                   /evidence="ECO:0007829|PDB:5N9J"
FT   HELIX           184..197
FT                   /evidence="ECO:0007829|PDB:3C0T"
SQ   SEQUENCE   200 AA;  23333 MW;  A61A9E49B83A86F0 CRC64;
     MEDISTEKTV ESLEAIRHRI AQIVQSLTHF LAILHQSESL SPWPTIHKNF NILLSQIHSL
     SNNLAAHSHT LQTTSIYPSL EFPVKEQEPL LTTLLRTKAL PEVEEWEANT LQEYEASISS
     QPKKKEANDA YQKDQLWDQA RIIFMEEREN YSWFDFVTRR QESEGEFVSQ RQLEIDRATE
     EQNANQMLTD ILSFMKSGKR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2025