MED9_BOVIN
ID MED9_BOVIN Reviewed; 145 AA.
AC Q2KHX9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 9;
DE AltName: Full=Mediator complex subunit 9;
GN Name=MED9; Synonyms=MED25;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC112843; AAI12844.1; -; mRNA.
DR RefSeq; NP_001074385.1; NM_001080916.2.
DR AlphaFoldDB; Q2KHX9; -.
DR SMR; Q2KHX9; -.
DR STRING; 9913.ENSBTAP00000027336; -.
DR PaxDb; Q2KHX9; -.
DR PRIDE; Q2KHX9; -.
DR Ensembl; ENSBTAT00000027336; ENSBTAP00000027336; ENSBTAG00000020517.
DR GeneID; 616966; -.
DR KEGG; bta:616966; -.
DR CTD; 55090; -.
DR VEuPathDB; HostDB:ENSBTAG00000020517; -.
DR VGNC; VGNC:31370; MED9.
DR eggNOG; ENOG502S51J; Eukaryota.
DR GeneTree; ENSGT00390000017379; -.
DR InParanoid; Q2KHX9; -.
DR OMA; TMPGIQL; -.
DR OrthoDB; 1524234at2759; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000020517; Expressed in Ammon's horn and 106 other tissues.
DR GO; GO:0070847; C:core mediator complex; IEA:Ensembl.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR011425; Med9.
DR InterPro; IPR039242; MED9_metazoa.
DR PANTHER; PTHR20844; PTHR20844; 1.
DR Pfam; PF07544; Med9; 1.
DR SUPFAM; SSF140718; SSF140718; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Activator; Coiled coil; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9NWA0"
FT CHAIN 2..145
FT /note="Mediator of RNA polymerase II transcription subunit
FT 9"
FT /id="PRO_0000304146"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..138
FT /evidence="ECO:0000255"
FT COMPBIAS 16..53
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWA0"
FT MOD_RES 109
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWA0"
SQ SEQUENCE 145 AA; 16116 MW; 3C656B8DF3BA6474 CRC64;
MASVGVAAGR QAEDTLPPPA EPPLPEMKPL PQPQPPPSVS AQQPQPAPKP PSPAGVKAEE
NCSFLPLVHS IIKCMDKDSP DIHQDLNTLK AKFQEMRKVV STMPGIHLSP EQQQQQLQRL
REQVRTKNEL LQKYKSLCMF EIPKE