ID   MED9_BOVIN              Reviewed;         145 AA.
AC   Q2KHX9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 9;
DE   AltName: Full=Mediator complex subunit 9;
GN   Name=MED9; Synonyms=MED25;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000305}.
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DR   EMBL; BC112843; AAI12844.1; -; mRNA.
DR   RefSeq; NP_001074385.1; NM_001080916.2.
DR   AlphaFoldDB; Q2KHX9; -.
DR   SMR; Q2KHX9; -.
DR   STRING; 9913.ENSBTAP00000027336; -.
DR   PaxDb; Q2KHX9; -.
DR   PRIDE; Q2KHX9; -.
DR   Ensembl; ENSBTAT00000027336; ENSBTAP00000027336; ENSBTAG00000020517.
DR   GeneID; 616966; -.
DR   KEGG; bta:616966; -.
DR   CTD; 55090; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020517; -.
DR   VGNC; VGNC:31370; MED9.
DR   eggNOG; ENOG502S51J; Eukaryota.
DR   GeneTree; ENSGT00390000017379; -.
DR   InParanoid; Q2KHX9; -.
DR   OMA; TMPGIQL; -.
DR   OrthoDB; 1524234at2759; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000020517; Expressed in Ammon's horn and 106 other tissues.
DR   GO; GO:0070847; C:core mediator complex; IEA:Ensembl.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR011425; Med9.
DR   InterPro; IPR039242; MED9_metazoa.
DR   PANTHER; PTHR20844; PTHR20844; 1.
DR   Pfam; PF07544; Med9; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Activator; Coiled coil; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NWA0"
FT   CHAIN           2..145
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   9"
FT                   /id="PRO_0000304146"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          111..138
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        16..53
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NWA0"
FT   MOD_RES         109
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NWA0"
SQ   SEQUENCE   145 AA;  16116 MW;  3C656B8DF3BA6474 CRC64;
     MASVGVAAGR QAEDTLPPPA EPPLPEMKPL PQPQPPPSVS AQQPQPAPKP PSPAGVKAEE
     NCSFLPLVHS IIKCMDKDSP DIHQDLNTLK AKFQEMRKVV STMPGIHLSP EQQQQQLQRL
     REQVRTKNEL LQKYKSLCMF EIPKE