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MED9_DICDI
ID   MED9_DICDI              Reviewed;         197 AA.
AC   Q54KY8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Putative mediator of RNA polymerase II transcription subunit 9;
DE   AltName: Full=Putative mediator complex subunit 9;
GN   Name=med9; ORFNames=DDB_G0287019;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18515835; DOI=10.1093/nar/gkn349;
RA   Bourbon H.-M.;
RT   "Comparative genomics supports a deep evolutionary origin for the large,
RT   four-module transcriptional mediator complex.";
RL   Nucleic Acids Res. 36:3993-4008(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000095; EAL63936.1; -; Genomic_DNA.
DR   RefSeq; XP_637444.1; XM_632352.1.
DR   AlphaFoldDB; Q54KY8; -.
DR   SMR; Q54KY8; -.
DR   STRING; 44689.DDB0266868; -.
DR   PaxDb; Q54KY8; -.
DR   EnsemblProtists; EAL63936; EAL63936; DDB_G0287019.
DR   GeneID; 8625912; -.
DR   KEGG; ddi:DDB_G0287019; -.
DR   dictyBase; DDB_G0287019; med9.
DR   eggNOG; ENOG502RICM; Eukaryota.
DR   HOGENOM; CLU_1386430_0_0_1; -.
DR   InParanoid; Q54KY8; -.
DR   PRO; PR:Q54KY8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0070847; C:core mediator complex; ISS:dictyBase.
DR   GO; GO:0005198; F:structural molecule activity; ISS:dictyBase.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:dictyBase.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..197
FT                   /note="Putative mediator of RNA polymerase II transcription
FT                   subunit 9"
FT                   /id="PRO_0000388649"
FT   REGION          126..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          83..117
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        126..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   197 AA;  22235 MW;  82F5CA65EC869D3F CRC64;
     MATPTNNYNT IVGSPMPTAT TAATTTTVTP TQKELNIEDL QLFPSILDII SRIKDDEIDL
     IRAINLANET RTKTIETLNK LPGINRSLEN QEELLKTYKQ TLKKKVELLE KLKKLEIFEK
     YNKIKSTSSQ SPQIQSKLEL QTELSQTEPS QTEPSQTEPS QTEPSQTESS QIESSQIESS
     QTETEKSKET TEDIMKE
 
 
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