ID   MED9_DROPS              Reviewed;         143 AA.
AC   Q290F0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 9;
DE   AltName: Full=Mediator complex subunit 9;
GN   Name=MED9; ORFNames=GA18683;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000305}.
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DR   EMBL; CM000071; EAL25412.2; -; Genomic_DNA.
DR   RefSeq; XP_001360837.2; XM_001360800.3.
DR   AlphaFoldDB; Q290F0; -.
DR   SMR; Q290F0; -.
DR   STRING; 7237.FBpp0277821; -.
DR   EnsemblMetazoa; FBtr0279383; FBpp0277821; FBgn0078683.
DR   GeneID; 4804249; -.
DR   KEGG; dpo:Dpse_GA18683; -.
DR   eggNOG; ENOG502S47C; Eukaryota.
DR   HOGENOM; CLU_1817785_0_0_1; -.
DR   InParanoid; Q290F0; -.
DR   OMA; ESQDCNH; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0078683; Expressed in male reproductive system and 3 other tissues.
DR   GO; GO:0016592; C:mediator complex; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR011425; Med9.
DR   InterPro; IPR039242; MED9_metazoa.
DR   PANTHER; PTHR20844; PTHR20844; 1.
DR   Pfam; PF07544; Med9; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..143
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   9"
FT                   /id="PRO_0000304151"
FT   COILED          84..141
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   143 AA;  16733 MW;  3B9F651DA286CEB9 CRC64;
     MELSPNNQIE DRKPILTADG LVQTSNSPFE PTISQETQTS NGIGTQCQLT VDQLDIEILP
     IIYDVVRCVE KDPLENAVKL RESQDCNHKI FELQKRFESA REQIRQLPGI DYNKDEQLQR
     LELLRNQFKL KQQLIRKYKD TEF