ID   MED9_XENLA              Reviewed;         115 AA.
AC   Q4V7L5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 9;
DE   AltName: Full=Mediator complex subunit 9;
GN   Name=med9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC097840; AAH97840.1; -; mRNA.
DR   RefSeq; NP_001089541.1; NM_001096072.1.
DR   AlphaFoldDB; Q4V7L5; -.
DR   SMR; Q4V7L5; -.
DR   DNASU; 734597; -.
DR   GeneID; 734597; -.
DR   KEGG; xla:734597; -.
DR   CTD; 734597; -.
DR   Xenbase; XB-GENE-987613; med9.L.
DR   OMA; VEKDPHD; -.
DR   OrthoDB; 1544360at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 734597; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR011425; Med9.
DR   InterPro; IPR039242; MED9_metazoa.
DR   PANTHER; PTHR20844; PTHR20844; 1.
DR   Pfam; PF07544; Med9; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..115
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   9"
FT                   /id="PRO_0000304149"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          31..107
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        11..31
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  13482 MW;  10688CA9A06BDDD1 CRC64;
     MATGGTVRPA EEPEEEEEEE DEAVEEEEEE DYTFLPLVHD IIKCMDKDSQ DVYQELNELK
     SKFQAMRKLV GNMPGIDMSP EEQQRHLQSL REQVQTKSEL LQKYKSLCMF EIPKE