MEDAG_MOUSE
ID MEDAG_MOUSE Reviewed; 303 AA.
AC Q14BA6; Q8BFY2; Q8C9B3; Q8CHK6; Q8R0K5; Q9CU47;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Mesenteric estrogen-dependent adipogenesis protein;
DE AltName: Full=Activated in W/Wv mouse stomach 3;
DE Short=mAWMS3;
DE AltName: Full=Mesenteric estrogen-dependent adipose 4;
DE Short=MEDA-4;
GN Name=Medag; Synonyms=Awms3, Meda4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RC TISSUE=Adipose tissue, Bone, Cerebellum, Corpus striatum, Head,
RC Hypothalamus, Medulla oblongata, Placenta, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Daigo Y., Takayama I., Fujino M.A.;
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, AND FUNCTION.
RX PubMed=22510272; DOI=10.1210/en.2011-2008;
RA Zhang H., Chen X., Sairam M.R.;
RT "Novel genes of visceral adiposity: identification of mouse and human
RT mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipogenic
RT function.";
RL Endocrinology 153:2665-2676(2012).
CC -!- FUNCTION: Involved in processes that promote adipocyte differentiation,
CC lipid accumulation, and glucose uptake in mature adipocytes.
CC {ECO:0000269|PubMed:22510272}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22510272}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14BA6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14BA6-2; Sequence=VSP_022716;
CC -!- TISSUE SPECIFICITY: Highly expressed in white adipose tissue compared
CC with other organs with higher expression in mature adipocyte fraction.
CC Significant expression is also detected in the heart, brain, and
CC pancreas. {ECO:0000269|PubMed:22510272}.
CC -!- INDUCTION: Down-regulated by estrogen treatment.
CC {ECO:0000269|PubMed:22510272}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31291.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC53804.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAE23601.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE37424.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK018128; BAB31084.1; -; mRNA.
DR EMBL; AK036605; BAC29504.1; -; mRNA.
DR EMBL; AK042557; BAC31291.2; ALT_INIT; mRNA.
DR EMBL; AK047657; BAC33115.1; -; mRNA.
DR EMBL; AK086092; BAC39607.1; -; mRNA.
DR EMBL; AK138268; BAE23601.1; ALT_INIT; mRNA.
DR EMBL; AK160904; BAE36082.1; -; mRNA.
DR EMBL; AK162725; BAE37037.1; -; mRNA.
DR EMBL; AK163617; BAE37424.1; ALT_INIT; mRNA.
DR EMBL; AK165529; BAE38240.1; -; mRNA.
DR EMBL; BC026658; AAH26658.1; -; mRNA.
DR EMBL; BC116246; AAI16247.1; -; mRNA.
DR EMBL; BC116247; AAI16248.1; -; mRNA.
DR EMBL; AB055406; BAC53804.1; ALT_FRAME; mRNA.
DR CCDS; CCDS19884.1; -. [Q14BA6-1]
DR CCDS; CCDS90023.1; -. [Q14BA6-2]
DR RefSeq; NP_081795.1; NM_027519.3. [Q14BA6-1]
DR RefSeq; XP_006505005.1; XM_006504942.3. [Q14BA6-2]
DR AlphaFoldDB; Q14BA6; -.
DR BioGRID; 214218; 1.
DR STRING; 10090.ENSMUSP00000090798; -.
DR iPTMnet; Q14BA6; -.
DR PhosphoSitePlus; Q14BA6; -.
DR jPOST; Q14BA6; -.
DR PaxDb; Q14BA6; -.
DR PRIDE; Q14BA6; -.
DR ProteomicsDB; 292290; -. [Q14BA6-1]
DR ProteomicsDB; 292291; -. [Q14BA6-2]
DR Antibodypedia; 53455; 18 antibodies from 9 providers.
DR DNASU; 70717; -.
DR Ensembl; ENSMUST00000093110; ENSMUSP00000090798; ENSMUSG00000029659. [Q14BA6-1]
DR Ensembl; ENSMUST00000201083; ENSMUSP00000144535; ENSMUSG00000029659. [Q14BA6-2]
DR GeneID; 70717; -.
DR KEGG; mmu:70717; -.
DR UCSC; uc009apt.1; mouse. [Q14BA6-1]
DR CTD; 84935; -.
DR MGI; MGI:1917967; Medag.
DR VEuPathDB; HostDB:ENSMUSG00000029659; -.
DR eggNOG; ENOG502REG3; Eukaryota.
DR GeneTree; ENSGT00390000018451; -.
DR HOGENOM; CLU_080194_0_0_1; -.
DR InParanoid; Q14BA6; -.
DR OMA; PGNEVIN; -.
DR OrthoDB; 1192582at2759; -.
DR PhylomeDB; Q14BA6; -.
DR TreeFam; TF328824; -.
DR BioGRID-ORCS; 70717; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Medag; mouse.
DR PRO; PR:Q14BA6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q14BA6; protein.
DR Bgee; ENSMUSG00000029659; Expressed in white adipose tissue and 59 other tissues.
DR Genevisible; Q14BA6; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IMP:UniProtKB.
DR InterPro; IPR039230; MEDAG.
DR InterPro; IPR043460; MEDAG/TEX26.
DR PANTHER; PTHR33769; PTHR33769; 1.
DR PANTHER; PTHR33769:SF3; PTHR33769:SF3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..303
FT /note="Mesenteric estrogen-dependent adipogenesis protein"
FT /id="PRO_0000274334"
FT VAR_SEQ 1..114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022716"
FT CONFLICT 5
FT /note="A -> W (in Ref. 1; BAB31084)"
FT /evidence="ECO:0000305"
FT CONFLICT 8
FT /note="P -> S (in Ref. 1; BAB31084)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="A -> E (in Ref. 2; AAH26658/AAI16247)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="E -> D (in Ref. 2; AAH26658/AAI16247)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="V -> L (in Ref. 3; BAC53804)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 303 AA; 34364 MW; E06A5C25AF6B80EC CRC64;
MATAACEPVA RPSLTSISSG ELRSLWTCDC ELALLPLSQL LRLQPGAFQL RGEQLLVPGP
GEPAAARGGF NVFGDGLVRL EGQLYRLSSY IKRYVELTNY CDYKDYRETI LSKPMVFFIN
VQTKKDISKE RTYAFLVNTR HPKIRRQIEQ GMDMVISSVI GESYRLQFDF QEVVKNFFPP
GTIVLNGENL SFTYEFKADA LFDFFYWFGL SNSTVKVHGK VLNLTSTNPE KKETIKLFLE
KMSEPLIRRS SFSDRKFSVT SRGSIDDVFN CNLSPRSSVT EPLLAEFSFP SLLECEETSS
QLI
