ID   MEDB_GIAIN              Reviewed;         857 AA.
AC   Q08014;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Median body protein;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Portland-1;
RX   PubMed=8510163; DOI=10.1006/jmbi.1993.1303;
RA   Marshall J., Holberton D.V.;
RT   "Sequence and structure of a new coiled coil protein from a microtubule
RT   bundle in Giardia.";
RL   J. Mol. Biol. 231:521-530(1993).
CC   -!- FUNCTION: May have a role in immobilizing the microtubules between cell
CC       divisions.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Median body.
CC   -!- DOMAIN: Shows an alpha-helical coiled coil structure (30 repeating
CC       heptads).
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DR   EMBL; X64517; CAA45820.1; -; mRNA.
DR   PIR; S33821; S33821.
DR   RefSeq; XP_001707409.1; XM_001707357.1.
DR   AlphaFoldDB; Q08014; -.
DR   SMR; Q08014; -.
DR   PRIDE; Q08014; -.
DR   GeneID; 5700294; -.
DR   KEGG; gla:GL50803_0016343; -.
DR   VEuPathDB; GiardiaDB:DHA2_16343; -.
DR   VEuPathDB; GiardiaDB:GL50581_686; -.
DR   VEuPathDB; GiardiaDB:GL50803_0016343; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule.
FT   CHAIN           1..857
FT                   /note="Median body protein"
FT                   /id="PRO_0000096398"
FT   COILED          120..796
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   857 AA;  100584 MW;  58FDAEA2D6682C0B CRC64;
     MSEAMVFSKI DEYTLFMSRS LQKSLKTFAE QVMALIYQYK DTLVEDRLAL TNTLDEAVQI
     LVDSGKEEAD KLGFNIYSAV SRYISEIWAS QSGQTTAAPP ATDIDGLHRQ LVALKNSLGQ
     NAELYEQRCQ LQAELRELQE FSENPAAAVE EIMQLKAQID ELKYGASNHN ALVQEKRDLE
     RHLADLRLSR QDTNSRLPQE IDRLRAEIED EKRNLPHMDD LQRQRDELQR QLDTIRRRGN
     TSGVMAEIEN IQRQIDDANS SASSEHELRM LRAEVETLRA QKSIVTRLEA ENADLRRELQ
     DIRGRAQEMS ASQRYSANQA QELQEKAMQA EELLQQKIEL RRQLHEALER ADAGEAALRD
     KRRLEDEIKG LQLRLTENDF TKERSILRNE IQAKTTEIDT LISDRRALET KLLNKEAEVD
     QLLYEKQLLK TELNSYRGTN EDIDKLTFEK RQLVEELNDL REKTIKYDQL AREKAALETE
     LKENSYNFDQ LLEQKQQMRS DLNALREKAA DYERVDRELR LKDKELEEKN AEIERLLEDR
     RVMRTELLHS KESATDVDSL IQEKRLRDRE LAHLRDRMSE YERVVEERIQ KEKENNLLKQ
     RITELEQQQR TATVRETEMS ALREKANELD GYNRERQARE HEINMLRDKA LESDKLRQDN
     RVMAMELTEL REKVQLLEKL QYEKRARDVE MLELRHKAMD VDTLVEEKQR LEMRLAELKI
     KVNNYDQLAD DKARLQEQLK EMSDKLIEFE MIMDDNRRLK LQVKELDLKT ANMEKLYEEY
     KKLEDQLKAT KAMTSTGMGV SAASPAFYKT KSMRLTQQNN QMKNTTDNLL TRDIPKLIDK
     LIERPAGTTT MGRSGKF