ID   MED_BACSU               Reviewed;         317 AA.
AC   O32436;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Transcriptional activator protein med;
DE   Flags: Precursor;
GN   Name=med; OrderedLocusNames=BSU11300;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / CU741;
RX   PubMed=9335269; DOI=10.1128/jb.179.20.6244-6253.1997;
RA   Ogura M., Ohshiro Y., Hirao S., Tanaka T.;
RT   "A new Bacillus subtilis gene, med, encodes a positive regulator of comK.";
RL   J. Bacteriol. 179:6244-6253(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Positive activator of the comK gene.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BMP lipoprotein family. {ECO:0000305}.
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DR   EMBL; D86376; BAA22928.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12971.2; -; Genomic_DNA.
DR   PIR; D69656; D69656.
DR   RefSeq; NP_389012.2; NC_000964.3.
DR   RefSeq; WP_003245494.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O32436; -.
DR   SMR; O32436; -.
DR   STRING; 224308.BSU11300; -.
DR   PaxDb; O32436; -.
DR   PRIDE; O32436; -.
DR   EnsemblBacteria; CAB12971; CAB12971; BSU_11300.
DR   GeneID; 936388; -.
DR   KEGG; bsu:BSU11300; -.
DR   PATRIC; fig|224308.179.peg.1215; -.
DR   eggNOG; COG1744; Bacteria.
DR   InParanoid; O32436; -.
DR   OMA; SALWHFE; -.
DR   PhylomeDB; O32436; -.
DR   BioCyc; BSUB:BSU11300-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR003760; PnrA-like.
DR   Pfam; PF02608; Bmp; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Activator; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal; Transcription; Transcription regulation.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           18..317
FT                   /note="Transcriptional activator protein med"
FT                   /id="PRO_0000018009"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   317 AA;  35311 MW;  2C02E39FBB869F8F CRC64;
     MITRLVMIFS VLLLLSGCGQ TPFKGKIEKV GMLFPDTIND LVWGTKGYKG LLNIQSKYNV
     DVYYKEGVKT EEDIINAIED FHKRGVNLLY GHGSEYAEVF NLVGEDYPDM EFVISNAKAK
     ADNVTSVHFS GEAMGFFGGM TAAHMSKTNQ VGVIASFTWQ PEVDGFIKGA KYENPDIEVN
     TKYTDHWDDD TTAVKLYQKM KNEGADVVYP AGDGYNVPVI QQIKKDGLYA IGYVTDQSDL
     GENTVLTSTV QNVDKAYEII AEQFNKGTLE GGDHYYDLNT GVVEMGTFSP LVDQDFQQRI
     AKLIKTYNKT GELPKNE