MEE14_ARATH
ID MEE14_ARATH Reviewed; 203 AA.
AC Q9XIM0; A8MQE2;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=CCG-binding protein 1;
DE Short=AtCBP1 {ECO:0000303|PubMed:26462908};
DE AltName: Full=Protein MATERNAL EFFECT EMBRYO ARREST 14 {ECO:0000305};
GN Name=MEE14 {ECO:0000303|PubMed:15634699};
GN Synonyms=CBP1 {ECO:0000303|PubMed:26462908};
GN OrderedLocusNames=At2g15890 {ECO:0000312|Araport:AT2G15890};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RX PubMed=15634699; DOI=10.1242/dev.01595;
RA Pagnussat G.C., Yu H.-J., Ngo Q.A., Rajani S., Mayalagu S., Johnson C.S.,
RA Capron A., Xie L.-F., Ye D., Sundaresan V.;
RT "Genetic and molecular identification of genes required for female
RT gametophyte development and function in Arabidopsis.";
RL Development 132:603-614(2005).
RN [6]
RP FUNCTION, SUBUNIT, INTERACTION WITH MEE12/CCG; MED7A; MED7B; MED9; AGL49;
RP AGL53; AGL75; AGL80; AGL81; AGL82; AGL103 AND NRPB1, SUBCELLULAR LOCATION,
RP ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=26462908; DOI=10.1105/tpc.15.00370;
RA Li H.J., Zhu S.S., Zhang M.X., Wang T., Liang L., Xue Y., Shi D.Q., Liu J.,
RA Yang W.C.;
RT "Arabidopsis CBP1 is a novel regulator of transcription initiation in
RT central cell-mediated pollen tube guidance.";
RL Plant Cell 27:2880-2893(2015).
CC -!- FUNCTION: Required for the development of the one-cell zygote and
CC endosperm in embryos (PubMed:15634699). Required for micropylar pollen
CC tube guidance, but has no effect on ovule development and gametophytic
CC cell fate specification. May connect transcription factors and the Pol
CC II machinery to regulate pollen tube attraction, via its interactions
CC with AGAMOUS-like (AGL) transcription factors, MEE14/CCG and the
CC Mediator complex (PubMed:26462908). {ECO:0000269|PubMed:15634699,
CC ECO:0000269|PubMed:26462908}.
CC -!- SUBUNIT: Homotetramer (PubMed:26462908). Interacts with MEE12/CCG,
CC MED7A, MED7B, MED9, AGL49, AGL53, AGL75, AGL80, AGL81, AGL82, AGL103
CC and NRPB1 (via CTD) (PubMed:26462908). {ECO:0000269|PubMed:26462908}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26462908}. Cytoplasm
CC {ECO:0000269|PubMed:26462908}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=CBP1.1 {ECO:0000303|PubMed:26462908};
CC IsoId=Q9XIM0-1; Sequence=Displayed;
CC Name=2; Synonyms=CBP1.2 {ECO:0000303|PubMed:26462908};
CC IsoId=Q9XIM0-2; Sequence=VSP_058072;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC Expressed in the central cell of mature ovules.
CC {ECO:0000269|PubMed:26462908}.
CC -!- DISRUPTION PHENOTYPE: Disrupted function of the female gametophyte.
CC Defective in micropylar pollen tube guidance leading to zygotic
CC lethality. {ECO:0000305|PubMed:26462908}.
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DR EMBL; AC006438; AAD41977.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06444.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06445.1; -; Genomic_DNA.
DR EMBL; AF324713; AAG40064.1; -; mRNA.
DR EMBL; AF339730; AAK00412.1; -; mRNA.
DR EMBL; AY065086; AAL38262.1; -; mRNA.
DR EMBL; BT008445; AAP37804.1; -; mRNA.
DR EMBL; AY086954; AAM64517.1; -; mRNA.
DR PIR; D84534; D84534.
DR RefSeq; NP_001077895.1; NM_001084426.1. [Q9XIM0-2]
DR RefSeq; NP_565383.1; NM_127149.4. [Q9XIM0-1]
DR AlphaFoldDB; Q9XIM0; -.
DR STRING; 3702.AT2G15890.1; -.
DR PaxDb; Q9XIM0; -.
DR PRIDE; Q9XIM0; -.
DR ProteomicsDB; 228856; -. [Q9XIM0-1]
DR EnsemblPlants; AT2G15890.1; AT2G15890.1; AT2G15890. [Q9XIM0-1]
DR EnsemblPlants; AT2G15890.2; AT2G15890.2; AT2G15890. [Q9XIM0-2]
DR GeneID; 816085; -.
DR Gramene; AT2G15890.1; AT2G15890.1; AT2G15890. [Q9XIM0-1]
DR Gramene; AT2G15890.2; AT2G15890.2; AT2G15890. [Q9XIM0-2]
DR KEGG; ath:AT2G15890; -.
DR Araport; AT2G15890; -.
DR TAIR; locus:2044556; AT2G15890.
DR eggNOG; ENOG502RXHM; Eukaryota.
DR InParanoid; Q9XIM0; -.
DR OMA; QKCENEL; -.
DR OrthoDB; 1604672at2759; -.
DR PhylomeDB; Q9XIM0; -.
DR PRO; PR:Q9XIM0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9XIM0; baseline and differential.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0036033; F:mediator complex binding; IPI:TAIR.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0050832; P:defense response to fungus; IEP:TAIR.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0010183; P:pollen tube guidance; IMP:TAIR.
DR InterPro; IPR037502; CBP1.
DR PANTHER; PTHR36345; PTHR36345; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..203
FT /note="CCG-binding protein 1"
FT /id="PRO_0000435411"
FT REGION 156..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 113..140
FT /note="Missing (in isoform 2)"
FT /id="VSP_058072"
SQ SEQUENCE 203 AA; 23154 MW; 3366921EFAE09FE4 CRC64;
MIKSVTLRSF HLPIEFNDTK FVSRPCFLAR SFPVVRCSST RDVPKLELFS RGKFDRILQD
PPLIEKAESE LSDYCSTLEG DDSYSCWRAY FELKDLEREK PKVEVENLIL QTGGLKSLIG
CLHGVASMEK DNKTKNGLHV GEESDREKGM NLHIHIPDGL PKSEQELEEE EKSKMPDSAF
TRLLRSKGTI PAWFSHAPDH ETD