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MEG11_MOUSE
ID   MEG11_MOUSE             Reviewed;        1091 AA.
AC   Q80T91; Q3TV46; Q8BKK7; Q8BX64;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 3.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Multiple epidermal growth factor-like domains protein 11;
DE            Short=Multiple EGF-like domains protein 11;
DE   Flags: Precursor;
GN   Name=Megf11; Synonyms=Kiaa1781;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT   The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 634-1091 (ISOFORM 4).
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum, and Spinal ganglion;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   FUNCTION IN NEURONAL MOSAIC SPACING.
RX   PubMed=22407321; DOI=10.1038/nature10877;
RA   Kay J.N., Chu M.W., Sanes J.R.;
RT   "MEGF10 and MEGF11 mediate homotypic interactions required for mosaic
RT   spacing of retinal neurons.";
RL   Nature 483:465-469(2012).
CC   -!- FUNCTION: May regulate the mosaic spacing of specific neuron subtypes
CC       in the retina through homotypic retinal neuron repulsion. Mosaics
CC       provide a mechanism to distribute each cell type evenly across the
CC       retina, ensuring that all parts of the visual field have access to a
CC       full set of processing elements. {ECO:0000269|PubMed:22407321}.
CC   -!- SUBUNIT: Homomer. Does not interact with MEGF10. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Basolateral cell membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Note=Forms an irregular, mosaic-like adhesion pattern in region of the
CC       cell that becomes firmely fixed to the substrate. Localized to
CC       protruding lamellipodia. Does not localize with MEGF10 (By similarity).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q80T91-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q80T91-2; Sequence=VSP_029253, VSP_029255, VSP_029257,
CC                                  VSP_029258;
CC       Name=3;
CC         IsoId=Q80T91-3; Sequence=VSP_029254;
CC       Name=4;
CC         IsoId=Q80T91-4; Sequence=VSP_029256, VSP_029259;
CC   -!- SIMILARITY: Belongs to the MEGF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC65837.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK122555; BAC65837.2; ALT_INIT; mRNA.
DR   EMBL; AK048840; BAC33471.1; -; mRNA.
DR   EMBL; AK051642; BAC34702.1; -; mRNA.
DR   EMBL; AK160406; BAE35774.1; -; mRNA.
DR   CCDS; CCDS23281.1; -. [Q80T91-2]
DR   RefSeq; NP_001127871.1; NM_001134399.1.
DR   RefSeq; NP_766110.3; NM_172522.4. [Q80T91-2]
DR   RefSeq; XP_006511052.1; XM_006510989.1. [Q80T91-4]
DR   AlphaFoldDB; Q80T91; -.
DR   SMR; Q80T91; -.
DR   GlyGen; Q80T91; 2 sites.
DR   iPTMnet; Q80T91; -.
DR   PhosphoSitePlus; Q80T91; -.
DR   PRIDE; Q80T91; -.
DR   ProteomicsDB; 292293; -. [Q80T91-1]
DR   ProteomicsDB; 292294; -. [Q80T91-2]
DR   ProteomicsDB; 292295; -. [Q80T91-3]
DR   ProteomicsDB; 292296; -. [Q80T91-4]
DR   Antibodypedia; 42885; 64 antibodies from 14 providers.
DR   DNASU; 214058; -.
DR   Ensembl; ENSMUST00000068967; ENSMUSP00000065353; ENSMUSG00000036466. [Q80T91-1]
DR   Ensembl; ENSMUST00000093829; ENSMUSP00000091349; ENSMUSG00000036466. [Q80T91-2]
DR   Ensembl; ENSMUST00000118485; ENSMUSP00000114035; ENSMUSG00000036466. [Q80T91-4]
DR   GeneID; 214058; -.
DR   KEGG; mmu:214058; -.
DR   UCSC; uc009qby.2; mouse. [Q80T91-3]
DR   UCSC; uc009qbz.2; mouse. [Q80T91-2]
DR   UCSC; uc009qca.2; mouse. [Q80T91-1]
DR   CTD; 84465; -.
DR   MGI; MGI:1920951; Megf11.
DR   VEuPathDB; HostDB:ENSMUSG00000036466; -.
DR   GeneTree; ENSGT00940000155333; -.
DR   HOGENOM; CLU_008281_0_0_1; -.
DR   InParanoid; Q80T91; -.
DR   OMA; CGKEAHF; -.
DR   OrthoDB; 561378at2759; -.
DR   PhylomeDB; Q80T91; -.
DR   TreeFam; TF332598; -.
DR   BioGRID-ORCS; 214058; 1 hit in 56 CRISPR screens.
DR   ChiTaRS; Megf11; mouse.
DR   PRO; PR:Q80T91; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q80T91; protein.
DR   Bgee; ENSMUSG00000036466; Expressed in cerebellum lobe and 137 other tissues.
DR   ExpressionAtlas; Q80T91; baseline and differential.
DR   Genevisible; Q80T91; MM.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0034109; P:homotypic cell-cell adhesion; IDA:UniProtKB.
DR   GO; GO:0010842; P:retina layer formation; IMP:UniProtKB.
DR   CDD; cd00055; EGF_Lam; 1.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR002049; LE_dom.
DR   Pfam; PF12661; hEGF; 3.
DR   Pfam; PF00053; Laminin_EGF; 8.
DR   SMART; SM00181; EGF; 17.
DR   SMART; SM00180; EGF_Lam; 16.
DR   PROSITE; PS00022; EGF_1; 17.
DR   PROSITE; PS01186; EGF_2; 17.
DR   PROSITE; PS50026; EGF_3; 15.
DR   PROSITE; PS51041; EMI; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..1091
FT                   /note="Multiple epidermal growth factor-like domains
FT                   protein 11"
FT                   /id="PRO_0000309736"
FT   TOPO_DOM        19..847
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        848..868
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        869..1091
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          23..100
FT                   /note="EMI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00384"
FT   DOMAIN          94..129
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          142..172
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          180..215
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          223..258
FT                   /note="EGF-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          266..301
FT                   /note="EGF-like 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          314..344
FT                   /note="EGF-like 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          398..433
FT                   /note="EGF-like 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          441..476
FT                   /note="EGF-like 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          484..519
FT                   /note="EGF-like 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          570..605
FT                   /note="EGF-like 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          613..650
FT                   /note="EGF-like 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          658..693
FT                   /note="EGF-like 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          706..736
FT                   /note="EGF-like 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          749..779
FT                   /note="EGF-like 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          787..822
FT                   /note="EGF-like 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   CARBOHYD        269
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        530
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..88
FT                   /evidence="ECO:0000255"
FT   DISULFID        53..62
FT                   /evidence="ECO:0000255"
FT   DISULFID        87..98
FT                   /evidence="ECO:0000255"
FT   DISULFID        102..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        119..128
FT                   /evidence="ECO:0000250"
FT   DISULFID        145..153
FT                   /evidence="ECO:0000250"
FT   DISULFID        147..160
FT                   /evidence="ECO:0000250"
FT   DISULFID        162..171
FT                   /evidence="ECO:0000250"
FT   DISULFID        184..196
FT                   /evidence="ECO:0000250"
FT   DISULFID        190..203
FT                   /evidence="ECO:0000250"
FT   DISULFID        205..214
FT                   /evidence="ECO:0000250"
FT   DISULFID        227..239
FT                   /evidence="ECO:0000250"
FT   DISULFID        233..246
FT                   /evidence="ECO:0000250"
FT   DISULFID        248..257
FT                   /evidence="ECO:0000250"
FT   DISULFID        270..282
FT                   /evidence="ECO:0000250"
FT   DISULFID        276..289
FT                   /evidence="ECO:0000250"
FT   DISULFID        291..300
FT                   /evidence="ECO:0000250"
FT   DISULFID        317..325
FT                   /evidence="ECO:0000250"
FT   DISULFID        319..332
FT                   /evidence="ECO:0000250"
FT   DISULFID        334..343
FT                   /evidence="ECO:0000250"
FT   DISULFID        402..414
FT                   /evidence="ECO:0000250"
FT   DISULFID        408..421
FT                   /evidence="ECO:0000250"
FT   DISULFID        423..432
FT                   /evidence="ECO:0000250"
FT   DISULFID        445..457
FT                   /evidence="ECO:0000250"
FT   DISULFID        451..464
FT                   /evidence="ECO:0000250"
FT   DISULFID        466..475
FT                   /evidence="ECO:0000250"
FT   DISULFID        488..500
FT                   /evidence="ECO:0000250"
FT   DISULFID        494..507
FT                   /evidence="ECO:0000250"
FT   DISULFID        509..518
FT                   /evidence="ECO:0000250"
FT   DISULFID        574..586
FT                   /evidence="ECO:0000250"
FT   DISULFID        580..593
FT                   /evidence="ECO:0000250"
FT   DISULFID        595..604
FT                   /evidence="ECO:0000250"
FT   DISULFID        617..631
FT                   /evidence="ECO:0000250"
FT   DISULFID        621..638
FT                   /evidence="ECO:0000250"
FT   DISULFID        640..649
FT                   /evidence="ECO:0000250"
FT   DISULFID        662..674
FT                   /evidence="ECO:0000250"
FT   DISULFID        668..681
FT                   /evidence="ECO:0000250"
FT   DISULFID        683..692
FT                   /evidence="ECO:0000250"
FT   DISULFID        709..717
FT                   /evidence="ECO:0000250"
FT   DISULFID        711..724
FT                   /evidence="ECO:0000250"
FT   DISULFID        726..735
FT                   /evidence="ECO:0000250"
FT   DISULFID        752..760
FT                   /evidence="ECO:0000250"
FT   DISULFID        754..767
FT                   /evidence="ECO:0000250"
FT   DISULFID        769..778
FT                   /evidence="ECO:0000250"
FT   DISULFID        791..803
FT                   /evidence="ECO:0000250"
FT   DISULFID        797..810
FT                   /evidence="ECO:0000250"
FT   DISULFID        812..821
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         100..131
FT                   /note="PLCTEECMHGRCVSPDTCHCEPGWGGPDCSSG -> R (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029253"
FT   VAR_SEQ         300..1091
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029254"
FT   VAR_SEQ         695..738
FT                   /note="ACPSGFWGSACFHTCSCHNGASCSAEDGACHCTPGWTGLFCTQR -> G
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029255"
FT   VAR_SEQ         903..998
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029256"
FT   VAR_SEQ         1018..1021
FT                   /note="DYMK -> VAPA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029257"
FT   VAR_SEQ         1022..1091
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029258"
FT   VAR_SEQ         1087..1091
FT                   /note="GRCLT -> EPTVSVVQEGRGHNSSYIQNPYDLPKNSHIPGHYDLLPVRQSP
FT                   AHGPFQEKQ (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029259"
FT   CONFLICT        815
FT                   /note="G -> E (in Ref. 2; BAE35774)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1057
FT                   /note="Y -> C (in Ref. 2; BAE35774)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1091 AA;  116059 MW;  EE9D70D73CED0477 CRC64;
     MAPSAVGLLV FLLQAALALN PEDPNVCSHW ESYAVTVQES YAHPFDQIYY TRCADILNWF
     KCTRHRISYK TAYRRGLRTM YRRRSQCCPG YYENGDFCIP LCTEECMHGR CVSPDTCHCE
     PGWGGPDCSS GCDSEHWGPH CSNRCQCQNG ALCNPITGAC VCAPGFRGWR CEELCAPGTH
     GKGCQLLCQC HHGASCDPRT GECLCAPGYT GVYCEELCPP GSHGAHCELR CPCQNGGTCH
     HITGECACPP GWTGAVCAQP CPPGTFGQNC SQDCPCHHGG QCDHVTGQCH CTAGYMGDRC
     QEECPFGTFG FLCSQRCDCH NGGQCSPATG ACECEPGYKG PSCQERLCPE GLHGPGCTLP
     CPCDTENTIS CHPVTGACTC QPGWSGHYCN ESCPAGYYGN GCQLPCTCQN GADCHSITGS
     CTCAPGFMGE VCAVPCAAGT YGPNCSSVCS CSNGGTCSPV DGSCTCREGW QGLDCSLPCP
     SGTWGLNCNE TCICANGAAC SPFDGSCACT PGWLGDSCEL PCPDGTFGLN CSEHCDCSHA
     DGCDPVTGHC CCLAGWTGIR CDSTCPPGRW GPNCSVSCSC ENGGSCSPED GSCECAPGFR
     GPLCQRICPP GFYGHGCAQP CPLCVHSRGP CHHISGICEC LPGFSGALCN QVCAGGHFGQ
     DCAQLCSCAN NGTCSPIDGS CQCFPGWIGK DCSQACPSGF WGSACFHTCS CHNGASCSAE
     DGACHCTPGW TGLFCTQRCP SAFFGKDCGH ICQCQNGASC DHITGKCTCR TGFSGRHCEQ
     RCAPGTFGYG CQQLCECMNN ATCDHVTGTC YCSPGFKGIR CDQAALMMDE LNPYTKISPA
     LGAERHSVGA VTGIVLLLFL VVVLLGLFAW RRRRQKEKGR DLAPRVSYTP AMRMTSTDYS
     LSDLSQSSSH AQCFSNASYH TLACGGPATS QASTLDRNSP TKLSNKSLDR DTAGWTPYSY
     VNVLDSHFQI SALEARYPPE DFYIELRHLS RHAEPHSPGT CGMDRRQNTY IMDKGFKDYM
     KESVCSSSTC SLNSSENPYA TIKDPPILTC KLPESSYVEM KSPVHLGSPY TDVPSLSTSN
     KNIYEVGRCL T
 
 
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