ID   ARHG9_BOVIN             Reviewed;         561 AA.
AC   Q58DL7;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Rho guanine nucleotide exchange factor 9;
DE   AltName: Full=Collybistin;
DE   AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 9;
GN   Name=ARHGEF9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for CDC42.
CC       Promotes formation of GPHN clusters (By similarity).
CC       {ECO:0000250|UniProtKB:Q9QX73}.
CC   -!- SUBUNIT: Interacts with GPHN. {ECO:0000250|UniProtKB:Q9QX73}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QX73}.
CC       Postsynaptic density {ECO:0000250|UniProtKB:Q3UTH8}.
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DR   EMBL; BT021580; AAX46427.1; -; mRNA.
DR   RefSeq; NP_001030495.1; NM_001035418.1.
DR   RefSeq; XP_015317209.1; XM_015461723.1.
DR   AlphaFoldDB; Q58DL7; -.
DR   BMRB; Q58DL7; -.
DR   SMR; Q58DL7; -.
DR   STRING; 9913.ENSBTAP00000016923; -.
DR   PaxDb; Q58DL7; -.
DR   PRIDE; Q58DL7; -.
DR   GeneID; 537718; -.
DR   KEGG; bta:537718; -.
DR   CTD; 23229; -.
DR   eggNOG; KOG3519; Eukaryota.
DR   HOGENOM; CLU_008436_2_1_1; -.
DR   InParanoid; Q58DL7; -.
DR   OrthoDB; 71658at2759; -.
DR   TreeFam; TF316832; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0098982; C:GABA-ergic synapse; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0099572; C:postsynaptic specialization; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0099150; P:regulation of postsynaptic specialization assembly; IBA:GO_Central.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11975; SH3_ARHGEF9; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035728; ARHGEF9_SH3.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein;
KW   Reference proteome; SH3 domain; Synapse.
FT   CHAIN           1..561
FT                   /note="Rho guanine nucleotide exchange factor 9"
FT                   /id="PRO_0000253894"
FT   DOMAIN          53..112
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          148..332
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          363..470
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          145..155
FT                   /note="Interaction with GPHN"
FT                   /evidence="ECO:0000250"
FT   REGION          499..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         547
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UTH8"
SQ   SEQUENCE   561 AA;  65980 MW;  1E668C1F8ED76FAD CRC64;
     MELDQVGWRR SRKLCTDNLD QGSKTLETCK NIGGYFKPQG PGTEHINELI TGDSIVSAEA
     VWDHVTMANR ELAFKAGDVI KVLDASNKDW WWGQIDDEEG WFPASFVRLW VNQEDGVEEG
     PSDVQNGHLD PNSDCLCLGR PLQNRDQMRA NVINEIMSTE RHYIKHLKDI CEGYLKQCRK
     RRDMFSDEQL KVIFGNIEDI YRFQMGFVRD LEKQYNNDDP HLSEIGPCFL EHQDGFWIYS
     EYCNNHLDAC MELSKLMKDS RYQHFFEACR LLQQMIDIAI DGFLLTPVQK ICKYPLQLAE
     LLKYTAQDHS DYRYVAAALA VMRNVTQQIN ERKRRLENID KIAQWQASVL DWEGEDILDR
     SSELIYTGEM AWIYQPYGRN QQRVFFLFDH QMVLCKKDLI RRDILYYKGR IDMDKYEVVD
     IEDGRDDDFN VSMKNAFKLH NKETEEIHLF FAKKLEEKIR WLRAFREERK MVQEDEKIGF
     EISENQKRQA AMTVRKVSKQ KGVNSARSVP PSYPPPQDPL NQGQYLVPDG IAQSQVFEFT
     EPKRSQSPFW QNFSRLTPFK K