MEGF6_HUMAN
ID MEGF6_HUMAN Reviewed; 1541 AA.
AC O75095; Q4AC86; Q5VV39;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 4.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Multiple epidermal growth factor-like domains protein 6;
DE Short=Multiple EGF-like domains protein 6;
DE AltName: Full=Epidermal growth factor-like protein 3;
DE Short=EGF-like protein 3;
DE Flags: Precursor;
GN Name=MEGF6; Synonyms=EGFL3, KIAA0815;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS GLY-131;
RP LEU-916 AND ALA-1137.
RC TISSUE=Brain, and Spleen;
RX PubMed=9693030; DOI=10.1006/geno.1998.5341;
RA Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.;
RT "Identification of high-molecular-weight proteins with multiple EGF-like
RT motifs by motif-trap screening.";
RL Genomics 51:27-34(1998).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- INTERACTION:
CC O75095; O15265: ATXN7; NbExp=2; IntAct=EBI-947597, EBI-708350;
CC O75095; O00555: CACNA1A; NbExp=2; IntAct=EBI-947597, EBI-766279;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O75095-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O75095-2; Sequence=VSP_037740, VSP_037741, VSP_037742,
CC VSP_037743, VSP_037744;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA32467.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE19678.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE19678.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB011539; BAA32467.2; ALT_INIT; mRNA.
DR EMBL; AB231860; BAE19678.1; ALT_SEQ; mRNA.
DR EMBL; AL512413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL513320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41237.1; -. [O75095-1]
DR RefSeq; NP_001400.3; NM_001409.3. [O75095-1]
DR AlphaFoldDB; O75095; -.
DR BioGRID; 108273; 14.
DR IntAct; O75095; 11.
DR MINT; O75095; -.
DR STRING; 9606.ENSP00000348982; -.
DR GlyGen; O75095; 3 sites, 1 O-linked glycan (1 site).
DR iPTMnet; O75095; -.
DR PhosphoSitePlus; O75095; -.
DR BioMuta; MEGF6; -.
DR jPOST; O75095; -.
DR MassIVE; O75095; -.
DR PaxDb; O75095; -.
DR PeptideAtlas; O75095; -.
DR PRIDE; O75095; -.
DR ProteomicsDB; 49758; -. [O75095-1]
DR ProteomicsDB; 49759; -. [O75095-2]
DR Antibodypedia; 59969; 30 antibodies from 13 providers.
DR DNASU; 1953; -.
DR Ensembl; ENST00000294599.8; ENSP00000294599.4; ENSG00000162591.16. [O75095-2]
DR Ensembl; ENST00000356575.9; ENSP00000348982.4; ENSG00000162591.16. [O75095-1]
DR GeneID; 1953; -.
DR KEGG; hsa:1953; -.
DR MANE-Select; ENST00000356575.9; ENSP00000348982.4; NM_001409.4; NP_001400.3.
DR UCSC; uc001akk.4; human. [O75095-1]
DR CTD; 1953; -.
DR DisGeNET; 1953; -.
DR GeneCards; MEGF6; -.
DR HGNC; HGNC:3232; MEGF6.
DR HPA; ENSG00000162591; Low tissue specificity.
DR MIM; 604266; gene.
DR neXtProt; NX_O75095; -.
DR OpenTargets; ENSG00000162591; -.
DR PharmGKB; PA27665; -.
DR VEuPathDB; HostDB:ENSG00000162591; -.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000156971; -.
DR HOGENOM; CLU_004998_0_0_1; -.
DR InParanoid; O75095; -.
DR OMA; ADAPCCQ; -.
DR OrthoDB; 25795at2759; -.
DR PhylomeDB; O75095; -.
DR TreeFam; TF332598; -.
DR PathwayCommons; O75095; -.
DR SignaLink; O75095; -.
DR BioGRID-ORCS; 1953; 10 hits in 1066 CRISPR screens.
DR ChiTaRS; MEGF6; human.
DR GenomeRNAi; 1953; -.
DR Pharos; O75095; Tdark.
DR PRO; PR:O75095; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O75095; protein.
DR Bgee; ENSG00000162591; Expressed in right coronary artery and 130 other tissues.
DR ExpressionAtlas; O75095; baseline and differential.
DR Genevisible; O75095; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF00053; Laminin_EGF; 5.
DR SMART; SM00181; EGF; 31.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 22.
DR SUPFAM; SSF57184; SSF57184; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 23.
DR PROSITE; PS01186; EGF_2; 24.
DR PROSITE; PS50026; EGF_3; 23.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS51041; EMI; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Disulfide bond; EGF-like domain;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..1541
FT /note="Multiple epidermal growth factor-like domains
FT protein 6"
FT /id="PRO_0000007524"
FT DOMAIN 44..125
FT /note="EMI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00384"
FT DOMAIN 124..159
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 161..201
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 206..242
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 238..284
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 285..325
FT /note="EGF-like 5; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 335..370
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 375..411
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 412..452
FT /note="EGF-like 8; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 516..552
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 560..595
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 603..638
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 736..770
FT /note="EGF-like 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 783..814
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 822..857
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 865..901
FT /note="EGF-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 909..944
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 955..987
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 995..1030
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1038..1073
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1081..1116
FT /note="EGF-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1124..1159
FT /note="EGF-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1211..1246
FT /note="EGF-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1254..1289
FT /note="EGF-like 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1297..1332
FT /note="EGF-like 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1345..1375
FT /note="EGF-like 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1383..1418
FT /note="EGF-like 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1469..1504
FT /note="EGF-like 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 1509..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 739
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..111
FT /evidence="ECO:0000255"
FT DISULFID 77..83
FT /evidence="ECO:0000255"
FT DISULFID 110..123
FT /evidence="ECO:0000255"
FT DISULFID 128..139
FT /evidence="ECO:0000250"
FT DISULFID 133..147
FT /evidence="ECO:0000250"
FT DISULFID 149..158
FT /evidence="ECO:0000250"
FT DISULFID 165..176
FT /evidence="ECO:0000250"
FT DISULFID 172..185
FT /evidence="ECO:0000250"
FT DISULFID 187..200
FT /evidence="ECO:0000250"
FT DISULFID 242..255
FT /evidence="ECO:0000250"
FT DISULFID 248..268
FT /evidence="ECO:0000250"
FT DISULFID 270..283
FT /evidence="ECO:0000250"
FT DISULFID 289..300
FT /evidence="ECO:0000250"
FT DISULFID 296..309
FT /evidence="ECO:0000250"
FT DISULFID 311..324
FT /evidence="ECO:0000250"
FT DISULFID 416..427
FT /evidence="ECO:0000250"
FT DISULFID 423..436
FT /evidence="ECO:0000250"
FT DISULFID 438..451
FT /evidence="ECO:0000250"
FT DISULFID 520..533
FT /evidence="ECO:0000250"
FT DISULFID 527..540
FT /evidence="ECO:0000250"
FT DISULFID 542..551
FT /evidence="ECO:0000250"
FT DISULFID 564..576
FT /evidence="ECO:0000250"
FT DISULFID 570..583
FT /evidence="ECO:0000250"
FT DISULFID 585..594
FT /evidence="ECO:0000250"
FT DISULFID 607..619
FT /evidence="ECO:0000250"
FT DISULFID 613..626
FT /evidence="ECO:0000250"
FT DISULFID 628..637
FT /evidence="ECO:0000250"
FT DISULFID 740..751
FT /evidence="ECO:0000250"
FT DISULFID 744..758
FT /evidence="ECO:0000250"
FT DISULFID 760..769
FT /evidence="ECO:0000250"
FT DISULFID 786..795
FT /evidence="ECO:0000250"
FT DISULFID 789..802
FT /evidence="ECO:0000250"
FT DISULFID 804..813
FT /evidence="ECO:0000250"
FT DISULFID 826..838
FT /evidence="ECO:0000250"
FT DISULFID 832..845
FT /evidence="ECO:0000250"
FT DISULFID 847..856
FT /evidence="ECO:0000250"
FT DISULFID 869..882
FT /evidence="ECO:0000250"
FT DISULFID 873..889
FT /evidence="ECO:0000250"
FT DISULFID 891..900
FT /evidence="ECO:0000250"
FT DISULFID 913..925
FT /evidence="ECO:0000250"
FT DISULFID 919..932
FT /evidence="ECO:0000250"
FT DISULFID 934..943
FT /evidence="ECO:0000250"
FT DISULFID 999..1011
FT /evidence="ECO:0000250"
FT DISULFID 1005..1018
FT /evidence="ECO:0000250"
FT DISULFID 1020..1029
FT /evidence="ECO:0000250"
FT DISULFID 1042..1054
FT /evidence="ECO:0000250"
FT DISULFID 1048..1061
FT /evidence="ECO:0000250"
FT DISULFID 1063..1072
FT /evidence="ECO:0000250"
FT DISULFID 1085..1097
FT /evidence="ECO:0000250"
FT DISULFID 1091..1104
FT /evidence="ECO:0000250"
FT DISULFID 1106..1115
FT /evidence="ECO:0000250"
FT DISULFID 1128..1140
FT /evidence="ECO:0000250"
FT DISULFID 1134..1147
FT /evidence="ECO:0000250"
FT DISULFID 1149..1158
FT /evidence="ECO:0000250"
FT DISULFID 1215..1227
FT /evidence="ECO:0000250"
FT DISULFID 1221..1234
FT /evidence="ECO:0000250"
FT DISULFID 1236..1245
FT /evidence="ECO:0000250"
FT DISULFID 1258..1270
FT /evidence="ECO:0000250"
FT DISULFID 1264..1277
FT /evidence="ECO:0000250"
FT DISULFID 1279..1288
FT /evidence="ECO:0000250"
FT DISULFID 1301..1313
FT /evidence="ECO:0000250"
FT DISULFID 1307..1320
FT /evidence="ECO:0000250"
FT DISULFID 1322..1331
FT /evidence="ECO:0000250"
FT DISULFID 1348..1356
FT /evidence="ECO:0000250"
FT DISULFID 1350..1363
FT /evidence="ECO:0000250"
FT DISULFID 1365..1374
FT /evidence="ECO:0000250"
FT DISULFID 1387..1399
FT /evidence="ECO:0000250"
FT DISULFID 1393..1406
FT /evidence="ECO:0000250"
FT DISULFID 1408..1417
FT /evidence="ECO:0000250"
FT DISULFID 1473..1485
FT /evidence="ECO:0000250"
FT DISULFID 1479..1492
FT /evidence="ECO:0000250"
FT DISULFID 1494..1503
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..159
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9693030"
FT /id="VSP_037740"
FT VAR_SEQ 160
FT /note="Y -> MGASRDRGLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYP
FT VSAGDQRP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9693030"
FT /id="VSP_037741"
FT VAR_SEQ 989..1075
FT /note="TCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGD
FT NCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKE -> K (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9693030"
FT /id="VSP_037742"
FT VAR_SEQ 1161..1205
FT /note="ACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQR -> G
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9693030"
FT /id="VSP_037743"
FT VAR_SEQ 1377..1454
FT /note="PCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGE
FT GCHQRCDCDGGAPCDPVTGLCLCPPG -> R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9693030"
FT /id="VSP_037744"
FT VARIANT 115
FT /note="M -> T (in dbSNP:rs7513275)"
FT /id="VAR_059258"
FT VARIANT 131
FT /note="S -> G (in dbSNP:rs2794340)"
FT /evidence="ECO:0000269|PubMed:9693030"
FT /id="VAR_058361"
FT VARIANT 313
FT /note="A -> V (in dbSNP:rs11585362)"
FT /id="VAR_059259"
FT VARIANT 587
FT /note="P -> L (in dbSNP:rs947345)"
FT /id="VAR_061155"
FT VARIANT 688
FT /note="L -> P (in dbSNP:rs2821008)"
FT /id="VAR_059260"
FT VARIANT 916
FT /note="R -> L (in dbSNP:rs7553399)"
FT /evidence="ECO:0000269|PubMed:9693030"
FT /id="VAR_058362"
FT VARIANT 1137
FT /note="G -> A (in dbSNP:rs4648506)"
FT /evidence="ECO:0000269|PubMed:9693030"
FT /id="VAR_058363"
FT VARIANT 1287
FT /note="R -> H (in dbSNP:rs57804877)"
FT /id="VAR_061156"
FT VARIANT 1536
FT /note="G -> S (in dbSNP:rs57484147)"
FT /id="VAR_061157"
SQ SEQUENCE 1541 AA; 161185 MW; EF2A7CB65140A7BB CRC64;
MSFLEEARAA GRAVVLALVL LLLPAVPVGA SVPPRPLLPL QPGMPHVCAE QELTLVGRRQ
PCVQALSHTV PVWKAGCGWQ AWCVGHERRT VYYMGYRQVY TTEARTVLRC CRGWMQQPDE
EGCLSAECSA SLCFHGGRCV PGSAQPCHCP PGFQGPRCQY DVDECRTHNG GCQHRCVNTP
GSYLCECKPG FRLHTDSRTC LAINSCALGN GGCQHHCVQL TITRHRCQCR PGFQLQEDGR
HCVRRSPCAN RNGSCMHRCQ VVRGLARCEC HVGYQLAADG KACEDVDECA AGLAQCAHGC
LNTQGSFKCV CHAGYELGAD GRQCYRIEME IVNSCEANNG GCSHGCSHTS AGPLCTCPRG
YELDTDQRTC IDVDDCADSP CCQQVCTNNP GGYECGCYAG YRLSADGCGC EDVDECASSR
GGCEHHCTNL AGSFQCSCEA GYRLHEDRRG CSPLEEPMVD LDGELPFVRP LPHIAVLQDE
LPQLFQDDDV GADEEEAELR GEHTLTEKFV CLDDSFGHDC SLTCDDCRNG GTCLLGLDGC
DCPEGWTGLI CNETCPPDTF GKNCSFSCSC QNGGTCDSVT GACRCPPGVS GTNCEDGCPK
GYYGKHCRKK CNCANRGRCH RLYGACLCDP GLYGRFCHLT CPPWAFGPGC SEECQCVQPH
TQSCDKRDGS CSCKAGFRGE RCQAECELGY FGPGCWQACT CPVGVACDSV SGECGKRCPA
GFQGEDCGQE CPVGTFGVNC SSSCSCGGAP CHGVTGQCRC PPGRTGEDCE ADCPEGRWGL
GCQEICPACQ HAARCDPETG ACLCLPGFVG SRCQDVCPAG WYGPSCQTRC SCANDGHCHP
ATGHCSCAPG WTGFSCQRAC DTGHWGPDCS HPCNCSAGHG SCDAISGLCL CEAGYVGPRC
EQQCPQGHFG PGCEQRCQCQ HGAACDHVSG ACTCPAGWRG TFCEHACPAG FFGLDCRSAC
NCTAGAACDA VNGSCLCPAG RRGPRCAETC PAHTYGHNCS QACACFNGAS CDPVHGQCHC
APGWMGPSCL QACPAGLYGD NCRHSCLCQN GGTCDPVSGH CACPEGWAGL ACEKECLPRD
VRAGCRHSGG CLNGGLCDPH TGRCLCPAGW TGDKCQSPCL RGWFGEACAQ RCSCPPGAAC
HHVTGACRCP PGFTGSGCEQ ACPPGSFGED CAQMCQCPGE NPACHPATGT CSCAAGYHGP
SCQQRCPPGR YGPGCEQLCG CLNGGSCDAA TGACRCPTGF LGTDCNLTCP QGRFGPNCTH
VCGCGQGAAC DPVTGTCLCP PGRAGVRCER GCPQNRFGVG CEHTCSCRNG GLCHASNGSC
SCGLGWTGRH CELACPPGRY GAACHLECSC HNNSTCEPAT GTCRCGPGFY GQACEHPCPP
GFHGAGCQGL CWCQHGAPCD PISGRCLCPA GFHGHFCERG CEPGSFGEGC HQRCDCDGGA
PCDPVTGLCL CPPGRSGATC NLDCRRGQFG PSCTLHCDCG GGADCDPVSG QCHCVDGYMG
PTCREGGPLR LPENPSLAQG SAGTLPASSR PTSRSGGPAR H