MEGF6_MOUSE
ID MEGF6_MOUSE Reviewed; 1572 AA.
AC Q80V70; A2A913;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Multiple epidermal growth factor-like domains protein 6;
DE Short=Multiple EGF-like domains protein 6;
DE AltName: Full=Epidermal growth factor-like protein 3;
DE Short=EGF-like protein 3;
DE Flags: Precursor;
GN Name=Megf6; Synonyms=Egfl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 917-1572.
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AL627123; CAM21839.1; -; Genomic_DNA.
DR EMBL; BC031402; AAH31402.1; -; mRNA.
DR EMBL; BC039980; AAH39980.1; -; mRNA.
DR EMBL; BC058571; AAH58571.1; -; mRNA.
DR CCDS; CCDS51398.1; -.
DR AlphaFoldDB; Q80V70; -.
DR STRING; 10090.ENSMUSP00000030897; -.
DR GlyGen; Q80V70; 1 site.
DR PhosphoSitePlus; Q80V70; -.
DR MaxQB; Q80V70; -.
DR PaxDb; Q80V70; -.
DR PRIDE; Q80V70; -.
DR ProteomicsDB; 293459; -.
DR MGI; MGI:1919351; Megf6.
DR eggNOG; KOG1218; Eukaryota.
DR InParanoid; Q80V70; -.
DR PhylomeDB; Q80V70; -.
DR TreeFam; TF332598; -.
DR ChiTaRS; Megf6; mouse.
DR PRO; PR:Q80V70; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80V70; protein.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF00053; Laminin_EGF; 6.
DR SMART; SM00181; EGF; 32.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 23.
DR SUPFAM; SSF57184; SSF57184; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS00022; EGF_1; 23.
DR PROSITE; PS01186; EGF_2; 23.
DR PROSITE; PS50026; EGF_3; 22.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51041; EMI; 1.
PE 2: Evidence at transcript level;
KW Calcium; Disulfide bond; EGF-like domain; Glycoprotein; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..1572
FT /note="Multiple epidermal growth factor-like domains
FT protein 6"
FT /id="PRO_0000055628"
FT DOMAIN 40..121
FT /note="EMI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00384"
FT DOMAIN 122..162
FT /note="EGF-like 1; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 163..203
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 287..327
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 414..454
FT /note="EGF-like 4; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 518..554
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 562..597
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 605..640
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 785..816
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 829..859
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 867..903
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 911..946
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 997..1032
FT /note="EGF-like 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1040..1075
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1083..1118
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1131..1161
FT /note="EGF-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1169..1204
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1256..1291
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1299..1334
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1342..1377
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1390..1420
FT /note="EGF-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1428..1463
FT /note="EGF-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 1000
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..107
FT /evidence="ECO:0000255"
FT DISULFID 73..79
FT /evidence="ECO:0000255"
FT DISULFID 106..119
FT /evidence="ECO:0000255"
FT DISULFID 126..137
FT /evidence="ECO:0000250"
FT DISULFID 133..146
FT /evidence="ECO:0000250"
FT DISULFID 148..161
FT /evidence="ECO:0000250"
FT DISULFID 167..178
FT /evidence="ECO:0000250"
FT DISULFID 174..187
FT /evidence="ECO:0000250"
FT DISULFID 189..202
FT /evidence="ECO:0000250"
FT DISULFID 291..302
FT /evidence="ECO:0000250"
FT DISULFID 298..311
FT /evidence="ECO:0000250"
FT DISULFID 313..326
FT /evidence="ECO:0000250"
FT DISULFID 418..429
FT /evidence="ECO:0000250"
FT DISULFID 425..438
FT /evidence="ECO:0000250"
FT DISULFID 440..453
FT /evidence="ECO:0000250"
FT DISULFID 522..535
FT /evidence="ECO:0000250"
FT DISULFID 529..542
FT /evidence="ECO:0000250"
FT DISULFID 544..553
FT /evidence="ECO:0000250"
FT DISULFID 566..578
FT /evidence="ECO:0000250"
FT DISULFID 572..585
FT /evidence="ECO:0000250"
FT DISULFID 587..596
FT /evidence="ECO:0000250"
FT DISULFID 609..621
FT /evidence="ECO:0000250"
FT DISULFID 615..628
FT /evidence="ECO:0000250"
FT DISULFID 630..639
FT /evidence="ECO:0000250"
FT DISULFID 788..797
FT /evidence="ECO:0000250"
FT DISULFID 791..804
FT /evidence="ECO:0000250"
FT DISULFID 806..815
FT /evidence="ECO:0000250"
FT DISULFID 832..840
FT /evidence="ECO:0000250"
FT DISULFID 834..847
FT /evidence="ECO:0000250"
FT DISULFID 849..858
FT /evidence="ECO:0000250"
FT DISULFID 871..884
FT /evidence="ECO:0000250"
FT DISULFID 875..891
FT /evidence="ECO:0000250"
FT DISULFID 893..902
FT /evidence="ECO:0000250"
FT DISULFID 915..927
FT /evidence="ECO:0000250"
FT DISULFID 921..934
FT /evidence="ECO:0000250"
FT DISULFID 936..945
FT /evidence="ECO:0000250"
FT DISULFID 1001..1013
FT /evidence="ECO:0000250"
FT DISULFID 1007..1020
FT /evidence="ECO:0000250"
FT DISULFID 1022..1031
FT /evidence="ECO:0000250"
FT DISULFID 1044..1056
FT /evidence="ECO:0000250"
FT DISULFID 1050..1063
FT /evidence="ECO:0000250"
FT DISULFID 1065..1074
FT /evidence="ECO:0000250"
FT DISULFID 1087..1099
FT /evidence="ECO:0000250"
FT DISULFID 1093..1106
FT /evidence="ECO:0000250"
FT DISULFID 1108..1117
FT /evidence="ECO:0000250"
FT DISULFID 1134..1142
FT /evidence="ECO:0000250"
FT DISULFID 1136..1149
FT /evidence="ECO:0000250"
FT DISULFID 1151..1160
FT /evidence="ECO:0000250"
FT DISULFID 1173..1185
FT /evidence="ECO:0000250"
FT DISULFID 1177..1192
FT /evidence="ECO:0000250"
FT DISULFID 1194..1203
FT /evidence="ECO:0000250"
FT DISULFID 1260..1272
FT /evidence="ECO:0000250"
FT DISULFID 1266..1279
FT /evidence="ECO:0000250"
FT DISULFID 1281..1290
FT /evidence="ECO:0000250"
FT DISULFID 1303..1315
FT /evidence="ECO:0000250"
FT DISULFID 1309..1322
FT /evidence="ECO:0000250"
FT DISULFID 1324..1333
FT /evidence="ECO:0000250"
FT DISULFID 1346..1358
FT /evidence="ECO:0000250"
FT DISULFID 1352..1365
FT /evidence="ECO:0000250"
FT DISULFID 1367..1376
FT /evidence="ECO:0000250"
FT DISULFID 1393..1401
FT /evidence="ECO:0000250"
FT DISULFID 1395..1408
FT /evidence="ECO:0000250"
FT DISULFID 1410..1419
FT /evidence="ECO:0000250"
FT DISULFID 1432..1444
FT /evidence="ECO:0000250"
FT DISULFID 1438..1451
FT /evidence="ECO:0000250"
FT DISULFID 1453..1462
FT /evidence="ECO:0000250"
FT CONFLICT 1055
FT /note="S -> N (in Ref. 1; CAM21839)"
FT /evidence="ECO:0000305"
FT CONFLICT 1110
FT /note="A -> T (in Ref. 1; CAM21839)"
FT /evidence="ECO:0000305"
FT CONFLICT 1458
FT /note="R -> H (in Ref. 1; CAM21839)"
FT /evidence="ECO:0000305"
FT CONFLICT 1481
FT /note="S -> C (in Ref. 2; AAH58571)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1572 AA; 164723 MW; 210DD9589B0FD85A CRC64;
MPVGVEARAS WRVVALTLLL LPAVPAASQP LPPRPLQPSM PHVCAEQKLT LVGHRQPCVQ
AFSRVVPVWR SGCGQQAWCV GQERRTVYYM SYRQVYATEA RTVFRCCPGW SQKPGQEGCL
SDVDECANAN GGCEGPCCNT VGGFYCRCPP GYQLQGDGKT CQDVDECRSH NGGCQHRCVN
TPGSYLCECK PGFRLHTDGR TCLAISSCTL GNGGCQHQCV QLTVTQHRCQ CRPQYQLQED
GRRCVRRSPC ADGNGGCMHT CQELRGLAHC GCHPGYQLAA DRKACEDVDE CALGLAQCAH
GCLNTQGSFK CVCHAGYELG ADGRQCYRIE MEIVNSCEAG NGGCSHGCSH TSTGPLCTCP
RGYELDEDQK TCIDIDDCAN SPCCQQVCAN TPGGYECSCF AGYRLNTDGC GCEDVDECAS
GHSGCEHHCS NLAGSFQCFC EAGYRLDEDR RGCTPLEESV VDLDGQLPFV RPLPHIAVLG
DELPQLFQDD YGAEEEAVAE LRGEHTLTEK FVCLDHSFGH DCSLTCDDCR NGGTCFPGLD
GCDCPEGWTG IICNETCPPD TFGKNCSSPC ICQNGGTCDP VSGACRCPPG VSGAHCEDGC
PKGFYGKHCR KKCHCANRGR CHRLYGACLC DPGLYGRFCH LACPPWAFGP GCSEDCLCEQ
SHTRSCNSKD GSCSCKAGFQ GERCEAECEP GSFGPGCRNR CTCRPGVACD PVSGECRTQC
PPGYQGEDCG QECPVGTFGV NCSGSCSCVG APCHRVTGEC LCPPGKTGED CGADCPEGRW
GLGCQEICPA CEHGASCDPE TGTCLCLPGF VGSRCQDACP AGWFGTGCQM RCACANDGHC
HPATGRCSCA PGWTGLSCQR ACDSGHWGPD CIHPCNCSAG HGNCDAVSGL CLCEAGYEGP
QCEQWCRQGY FGPGCEQKCR CEHGATCDHV SGACTCPAGW RGSFCEHACP AGFFGLDCGS
ACNCSAGAPC DAVTGSCICP AGRWGPHCAQ TCPPLTFGLN CSQICTCFNG ASCDPVLGQC
HCAPGWMGPT CLQACPAGLY GKNCQHSCLC RNGGSCDPIL GQCTCPEGWT GLACENECLP
GHHGAGCRLN CSCLNGGTCD RLTGHCRCPA GWTGDKCQSP CVSGMFGVHC EEHCACRKGA
TCHHVTGACL CPPGWRGSHC EQACPRGWFG EACAQRCHCP PGASCHHVSG ECHCPPGFTG
PGCEQACQPG TFGKDCEHPC QCPGETWACH PASGACVCAA GYHGTDCQQR CPSGRYGPGC
EQICKCLNGG TCDPATGACY CPAGFLGADC SLACPQGRFG PSCAHVCTCG QGAACDPVSG
TCICPPGKTG GHCERGCPQD RFGKGCEHKC ACRNGGLCHA TNGSCSCPLG WMGPHCEHAC
PAGRYGAACL LECSCQNNGS CEPTSGACLC GPGFYGQACE DTCPAGFHGS GCQRVCECQQ
GAPCDPVSGR CLCPAGFRGQ FCERGCKPGF FGDGCLQQCN SPTGVPCDPI SGLCLCPPGR
AGTTCDLDCR RGRFGPGCAL RCDCGGGADC DPISGQCHCV DSYTGPTCRE VPTQLSSIRP
APQHSSSKAM KH
