MEGF6_RAT
ID MEGF6_RAT Reviewed; 1574 AA.
AC O88281;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Multiple epidermal growth factor-like domains protein 6;
DE Short=Multiple EGF-like domains protein 6;
DE AltName: Full=Epidermal growth factor-like protein 3;
DE Short=EGF-like protein 3;
DE Flags: Precursor;
GN Name=Megf6; Synonyms=Egfl3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=9693030; DOI=10.1006/geno.1998.5341;
RA Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.;
RT "Identification of high-molecular-weight proteins with multiple EGF-like
RT motifs by motif-trap screening.";
RL Genomics 51:27-34(1998).
RN [2]
RP PROTEIN SEQUENCE OF 482-486, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA Lubec G., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in lung. {ECO:0000269|PubMed:9693030}.
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DR EMBL; AB011532; BAA32462.1; -; mRNA.
DR PIR; T13954; T13954.
DR RefSeq; NP_075244.1; NM_022955.1.
DR AlphaFoldDB; O88281; -.
DR STRING; 10116.ENSRNOP00000052252; -.
DR PaxDb; O88281; -.
DR PRIDE; O88281; -.
DR GeneID; 65049; -.
DR KEGG; rno:65049; -.
DR UCSC; RGD:621188; rat.
DR CTD; 1953; -.
DR RGD; 621188; Megf6.
DR eggNOG; KOG1218; Eukaryota.
DR InParanoid; O88281; -.
DR OrthoDB; 25795at2759; -.
DR PhylomeDB; O88281; -.
DR PRO; PR:O88281; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00053; Laminin_EGF; 5.
DR SMART; SM00181; EGF; 32.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 23.
DR SUPFAM; SSF57184; SSF57184; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS00022; EGF_1; 23.
DR PROSITE; PS01186; EGF_2; 23.
DR PROSITE; PS50026; EGF_3; 21.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51041; EMI; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; EGF-like domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..1574
FT /note="Multiple epidermal growth factor-like domains
FT protein 6"
FT /id="PRO_0000007525"
FT DOMAIN 40..122
FT /note="EMI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00384"
FT DOMAIN 123..163
FT /note="EGF-like 1; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 164..204
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 205..246
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 247..287
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 288..328
FT /note="EGF-like 5; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 334..374
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 375..412
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 415..455
FT /note="EGF-like 8; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 520..556
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 564..599
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 607..642
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 650..687
FT /note="EGF-like 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 695..732
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 740..774
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 782..818
FT /note="EGF-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 826..861
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 869..905
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 913..948
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 956..991
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 999..1034
FT /note="EGF-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1042..1077
FT /note="EGF-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1085..1120
FT /note="EGF-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1128..1163
FT /note="EGF-like 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1171..1206
FT /note="EGF-like 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1214..1250
FT /note="EGF-like 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1258..1293
FT /note="EGF-like 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1301..1336
FT /note="EGF-like 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1344..1379
FT /note="EGF-like 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1387..1422
FT /note="EGF-like 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1430..1465
FT /note="EGF-like 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1473..1508
FT /note="EGF-like 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1516..1551
FT /note="EGF-like 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 1555..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 44..108
FT /evidence="ECO:0000250"
FT DISULFID 74..80
FT /evidence="ECO:0000250"
FT DISULFID 107..120
FT /evidence="ECO:0000250"
FT DISULFID 127..138
FT /evidence="ECO:0000250"
FT DISULFID 134..147
FT /evidence="ECO:0000250"
FT DISULFID 149..162
FT /evidence="ECO:0000250"
FT DISULFID 168..179
FT /evidence="ECO:0000250"
FT DISULFID 175..188
FT /evidence="ECO:0000250"
FT DISULFID 190..203
FT /evidence="ECO:0000250"
FT DISULFID 209..220
FT /evidence="ECO:0000250"
FT DISULFID 216..230
FT /evidence="ECO:0000250"
FT DISULFID 232..245
FT /evidence="ECO:0000250"
FT DISULFID 251..262
FT /evidence="ECO:0000250"
FT DISULFID 258..271
FT /evidence="ECO:0000250"
FT DISULFID 273..286
FT /evidence="ECO:0000250"
FT DISULFID 292..303
FT /evidence="ECO:0000250"
FT DISULFID 299..312
FT /evidence="ECO:0000250"
FT DISULFID 314..327
FT /evidence="ECO:0000250"
FT DISULFID 338..349
FT /evidence="ECO:0000250"
FT DISULFID 345..358
FT /evidence="ECO:0000250"
FT DISULFID 360..373
FT /evidence="ECO:0000250"
FT DISULFID 379..389
FT /evidence="ECO:0000250"
FT DISULFID 385..398
FT /evidence="ECO:0000250"
FT DISULFID 400..411
FT /evidence="ECO:0000250"
FT DISULFID 419..430
FT /evidence="ECO:0000250"
FT DISULFID 426..439
FT /evidence="ECO:0000250"
FT DISULFID 441..454
FT /evidence="ECO:0000250"
FT DISULFID 524..537
FT /evidence="ECO:0000250"
FT DISULFID 531..544
FT /evidence="ECO:0000250"
FT DISULFID 546..555
FT /evidence="ECO:0000250"
FT DISULFID 568..580
FT /evidence="ECO:0000250"
FT DISULFID 574..587
FT /evidence="ECO:0000250"
FT DISULFID 589..598
FT /evidence="ECO:0000250"
FT DISULFID 611..623
FT /evidence="ECO:0000250"
FT DISULFID 617..630
FT /evidence="ECO:0000250"
FT DISULFID 632..641
FT /evidence="ECO:0000250"
FT DISULFID 654..668
FT /evidence="ECO:0000250"
FT DISULFID 660..675
FT /evidence="ECO:0000250"
FT DISULFID 677..686
FT /evidence="ECO:0000250"
FT DISULFID 699..711
FT /evidence="ECO:0000250"
FT DISULFID 705..718
FT /evidence="ECO:0000250"
FT DISULFID 722..731
FT /evidence="ECO:0000250"
FT DISULFID 744..755
FT /evidence="ECO:0000250"
FT DISULFID 750..762
FT /evidence="ECO:0000250"
FT DISULFID 764..773
FT /evidence="ECO:0000250"
FT DISULFID 786..799
FT /evidence="ECO:0000250"
FT DISULFID 793..806
FT /evidence="ECO:0000250"
FT DISULFID 808..817
FT /evidence="ECO:0000250"
FT DISULFID 830..842
FT /evidence="ECO:0000250"
FT DISULFID 836..849
FT /evidence="ECO:0000250"
FT DISULFID 851..860
FT /evidence="ECO:0000250"
FT DISULFID 873..886
FT /evidence="ECO:0000250"
FT DISULFID 879..893
FT /evidence="ECO:0000250"
FT DISULFID 895..904
FT /evidence="ECO:0000250"
FT DISULFID 917..929
FT /evidence="ECO:0000250"
FT DISULFID 923..936
FT /evidence="ECO:0000250"
FT DISULFID 938..947
FT /evidence="ECO:0000250"
FT DISULFID 960..972
FT /evidence="ECO:0000250"
FT DISULFID 966..979
FT /evidence="ECO:0000250"
FT DISULFID 981..990
FT /evidence="ECO:0000250"
FT DISULFID 1003..1015
FT /evidence="ECO:0000250"
FT DISULFID 1009..1022
FT /evidence="ECO:0000250"
FT DISULFID 1024..1033
FT /evidence="ECO:0000250"
FT DISULFID 1046..1058
FT /evidence="ECO:0000250"
FT DISULFID 1052..1065
FT /evidence="ECO:0000250"
FT DISULFID 1067..1076
FT /evidence="ECO:0000250"
FT DISULFID 1089..1101
FT /evidence="ECO:0000250"
FT DISULFID 1095..1108
FT /evidence="ECO:0000250"
FT DISULFID 1110..1119
FT /evidence="ECO:0000250"
FT DISULFID 1132..1144
FT /evidence="ECO:0000250"
FT DISULFID 1138..1151
FT /evidence="ECO:0000250"
FT DISULFID 1153..1162
FT /evidence="ECO:0000250"
FT DISULFID 1175..1187
FT /evidence="ECO:0000250"
FT DISULFID 1181..1194
FT /evidence="ECO:0000250"
FT DISULFID 1196..1205
FT /evidence="ECO:0000250"
FT DISULFID 1218..1231
FT /evidence="ECO:0000250"
FT DISULFID 1224..1238
FT /evidence="ECO:0000250"
FT DISULFID 1240..1249
FT /evidence="ECO:0000250"
FT DISULFID 1262..1274
FT /evidence="ECO:0000250"
FT DISULFID 1268..1281
FT /evidence="ECO:0000250"
FT DISULFID 1283..1292
FT /evidence="ECO:0000250"
FT DISULFID 1305..1317
FT /evidence="ECO:0000250"
FT DISULFID 1311..1324
FT /evidence="ECO:0000250"
FT DISULFID 1326..1335
FT /evidence="ECO:0000250"
FT DISULFID 1348..1360
FT /evidence="ECO:0000250"
FT DISULFID 1354..1367
FT /evidence="ECO:0000250"
FT DISULFID 1369..1378
FT /evidence="ECO:0000250"
FT DISULFID 1391..1403
FT /evidence="ECO:0000250"
FT DISULFID 1397..1410
FT /evidence="ECO:0000250"
FT DISULFID 1412..1421
FT /evidence="ECO:0000250"
FT DISULFID 1434..1446
FT /evidence="ECO:0000250"
FT DISULFID 1440..1453
FT /evidence="ECO:0000250"
FT DISULFID 1455..1464
FT /evidence="ECO:0000250"
FT DISULFID 1477..1489
FT /evidence="ECO:0000250"
FT DISULFID 1483..1496
FT /evidence="ECO:0000250"
FT DISULFID 1498..1507
FT /evidence="ECO:0000250"
FT DISULFID 1520..1532
FT /evidence="ECO:0000250"
FT DISULFID 1526..1539
FT /evidence="ECO:0000250"
FT DISULFID 1541..1550
FT /evidence="ECO:0000250"
SQ SEQUENCE 1574 AA; 165447 MW; 2B48533D8F77F6E7 CRC64;
MPVRAEARAA WRVVALALLL LPAMPAASPP LTPRPLQPSM PHVCAEQKLT LVGHRQPCVQ
AFSRIVPVWR RTGCAQQAWC IGQERRTVYY MSYRQVYATE ARTVFRCCPG WSQKPGQEGC
LSDVDECASA NGGCEGPCCN TVGGFYCRCP PGYQLQGDGK TCQDVDECRA HNGGCQHRCV
NTPGSYLCEC KPGFRLHTDG RTCLAISSCT LGNGGCQHQC VQLTVTQHRC QCRPQYQLQE
DGRRCVRRSP CAEGNGGCMH ICQELRGLAH CGCHPGYQLA ADRKTCEDVD ECALGLAQCA
HGCLNTQGSF KCVCHAGYEL GADGRQCYRI EMEIVNSCEA GNGGCSHGCS HTSTGPLCTC
PRGYELDEDQ KTCIDIDDCA NSPCCQQACA NTPGGYECSC FAGYRLNTDG CGCEDVDECA
SGHGGCEHHC SNLAGSFQCF CEAGYRLDED RRGCTSLEES VVDLDGRLPF VRPLPHIAVL
RDELPRLFQD DYGAEEEAAA AELRGEHTLT EKFVCLDHSF GHDCSLTCDD CRNGGTCFPG
QDGCDCPEGW TGIICNETCP PDTFGKNCSS PCTCQNGGTC DPVLGACRCP PGVSGAHCED
GCPKGFYGKH CRKKCHCANR GRCHRLYGAC LCDPGLYGRF CHLACPPWAF GPGCSEDCLC
EQSHTRSCNP KDGSCSCKAG FQGERCQAEC ESGFFGPGCR HRCTCQPGVA CDPVSGECRT
QCPPGYQGED CGQECPVGTF GVNCSGSCSC VGAPCHRVTG ECLCPPGKTG EDCGADCPEG
RWGLGCQEIC PACEHGASCN PETGTCLCLP GFVGSRCQDT CSAGWYGTGC QIRCACANDG
HCDPTTGRCS CAPGWTGLSC QRACDSGHWG PDCIHPCNCS AGHGNCDAVS GLCLCEAGYE
GPRCEQSCRQ GYYGPSCEQK CRCEHGAACD HVSGACTCPA GWRGSFCEHA CPAGFFGLDC
DSACNCSAGA PCDAVTGSCI CPAGRWGPRC AQSCPPLTFG LNCSQICTCF NGASCDSVTG
QCHCAPGWMG PTCLQACPPG LYGKNCQHSC LCRNGGRCDP ILGQCTCPEG WTGLACENEC
LPGHYAAGCQ LNCSCLHGGI CDRLTGHCLC PAGWTGDKCQ SSCVSGTFGV HCEEHCACRK
GASCHHVTGA CFCPPGWRGP HCEQACPRGW FGEACAQRCL CPTNASCHHV TGECRCPPGF
TGLSCEQACQ PGTFGKDCEH LCQCPGETWA CDPASGVCTC AAGYHGTGCL QRCPSGRYGP
GCEHICKCLN GGTCDPATGA CYCPAGFLGA DCSLACPQGR FGPSCAHVCA CRQGAACDPV
SGACICSPGK TGVRCEHGCP QDRFGKGCEL KCACRNGGLC HATNGSCSCP LGWMGPHCEH
ACPAGRYGAA CLLECFCQNN GSCEPTTGAC LCGPGFYGQA CEHSCPSGFH GPGCQRVCEC
QQGAPCDPVS GQCLCPAGFH GQFCEKGCES GSFGDGCLQQ CNCHTGVPCD PISGLCLCPP
GRTGAACDLD CRRGRFGPGC ALRCDCGGGA DCDPISGQCH CVDSYMGPTC REVPTQISSS
RPAPQHPSSR AMKH
