ID   MEI3B_XENLA             Reviewed;         451 AA.
AC   Q7ZY13; Q2VPN5;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Homeobox protein meis3-B {ECO:0000250|UniProtKB:Q5U4X3};
GN   Name=meis3-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH44024.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:AAI08489.1}, and
RC   Tail bud {ECO:0000312|EMBL:AAH44024.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: A caudalizing protein which is required to pattern the
CC       anterior/posterior (A/P) axis during central nervous system (CNS)
CC       formation. Inhibits anterior neural expression and acts as a
CC       transcriptional activator to induce posterior neural gene expression.
CC       Maintains a proper A/P balance required for hindbrain formation by
CC       activating the FGF/MAPK pathway, which modulates the planar cell
CC       polarity (PCP) pathway. Interacts with retinoid signaling during
CC       hindbrain patterning (By similarity). {ECO:0000250|UniProtKB:Q5U4X3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000255}.
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DR   EMBL; BC044024; AAH44024.1; -; mRNA.
DR   EMBL; BC108488; AAI08489.1; -; mRNA.
DR   RefSeq; NP_001079532.1; NM_001086063.1.
DR   AlphaFoldDB; Q7ZY13; -.
DR   SMR; Q7ZY13; -.
DR   DNASU; 379219; -.
DR   GeneID; 379219; -.
DR   KEGG; xla:379219; -.
DR   CTD; 379219; -.
DR   Xenbase; XB-GENE-485341; meis3.S.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 379219; Expressed in neurula embryo and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0030902; P:hindbrain development; ISS:UniProtKB.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR032453; PKNOX/Meis_N.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF16493; Meis_PKNOX_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..451
FT                   /note="Homeobox protein meis3-B"
FT                   /id="PRO_0000355572"
FT   DOMAIN          102..185
FT                   /note="MEIS N-terminal"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        267..329
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          33..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        346
FT                   /note="D -> G (in Ref. 1; AAH44024)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   451 AA;  48969 MW;  0F1528239194E957 CRC64;
     MAQRYDEMVH YPGLDGMSLA GFADAHTGRA LQHHSLSQST PYGSTGAAHR VPMPPGMGSN
     DGLKREKDEI YGHPLFPLLA LVFEKCELAT CSPRDNSGSF PGGDVCSSDS FNEDIAVFAK
     QVRTEKPLFS SNPELDNLMI QAIQVLRFHL LELEKVHDLC DNFCHRYITC LKGKMPIDLV
     IDDRDGSSKS DLEDFTGSCT SLSDQNNTWI RDHDETGSTH SGTPGPSSGG LASQSGDNSS
     EQGDCMDNSV ASPSTGDDDD LDRDKKRNKK RGIFPKVATN IMRAWLFQHL SHPYPSEEQK
     KQLAQDTGLT ILQVNNWFIN ARRRIVQPMI DQSNRTGQGG APYSPDGQNM GGYVMDGQQH
     MGIRPPGFQG IPGDYTAAPS TMPMGFPPAG YTPAIPPHSA GLRHGPSLHS YLPGHPHSMI
     LPAGASPHHL VSAQSPADAL LNGQNIDIHA H