ID   MEI4_DANRE              Reviewed;         363 AA.
AC   Q5PNP6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Meiosis-specific protein MEI4;
GN   Name=mei4; ORFNames=si:ch211-241p10.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 109-343.
RX   PubMed=12234666; DOI=10.1016/s0378-1119(02)00791-6;
RA   Zeng S., Gong Z.;
RT   "Expressed sequence tag analysis of expression profiles of zebrafish testis
RT   and ovary.";
RL   Gene 294:45-53(2002).
CC   -!- FUNCTION: Required for DNA double-strand breaks (DSBs) formation in
CC       unsynapsed regions during meiotic recombination.
CC       {ECO:0000250|UniProtKB:Q8BRM6}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q8BRM6}.
CC       Note=Specifically localizes to unsynapsed chromosomal regions during
CC       meiosis. {ECO:0000250|UniProtKB:Q8BRM6}.
CC   -!- SIMILARITY: Belongs to the MEI4L family. {ECO:0000305}.
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DR   EMBL; BX537259; CAI29392.1; -; Genomic_DNA.
DR   EMBL; BM141230; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001153485.1; NM_001160013.1.
DR   AlphaFoldDB; Q5PNP6; -.
DR   SMR; Q5PNP6; -.
DR   STRING; 7955.ENSDARP00000064482; -.
DR   PaxDb; Q5PNP6; -.
DR   Ensembl; ENSDART00000137135; ENSDARP00000116446; ENSDARG00000043912.
DR   GeneID; 568897; -.
DR   KEGG; dre:568897; -.
DR   CTD; 101928601; -.
DR   ZFIN; ZDB-GENE-040724-211; mei4.
DR   eggNOG; ENOG502S31K; Eukaryota.
DR   GeneTree; ENSGT00390000013856; -.
DR   HOGENOM; CLU_055456_0_0_1; -.
DR   InParanoid; Q5PNP6; -.
DR   OrthoDB; 1116097at2759; -.
DR   PhylomeDB; Q5PNP6; -.
DR   PRO; PR:Q5PNP6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000043912; Expressed in testis and 10 other tissues.
DR   ExpressionAtlas; Q5PNP6; baseline.
DR   GO; GO:0000800; C:lateral element; ISS:UniProtKB.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISS:UniProtKB.
DR   GO; GO:0042138; P:meiotic DNA double-strand break formation; ISS:UniProtKB.
DR   GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR025888; MEI4.
DR   PANTHER; PTHR28575; PTHR28575; 1.
DR   Pfam; PF13971; Mei4; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA recombination; Meiosis; Reference proteome.
FT   CHAIN           1..363
FT                   /note="Meiosis-specific protein MEI4"
FT                   /id="PRO_0000343705"
FT   REGION          109..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        233
FT                   /note="N -> K (in Ref. 2; BM141230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        284
FT                   /note="R -> G (in Ref. 2; BM141230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        291
FT                   /note="R -> G (in Ref. 2; BM141230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        325
FT                   /note="V -> M (in Ref. 2; BM141230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        332
FT                   /note="R -> Q (in Ref. 2; BM141230)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   363 AA;  41212 MW;  D1FE9AF50E151976 CRC64;
     MEGKSASCPE GVVSWYIRTS RLAVALAIIK LRPPGGARQF TESLAERLKR QDESWKSKAE
     GLHEDLLHLR QELLLTRTLL NTRSSAGQAP GQEIAKVLSQ DDTREVNSGT LQTCLPPTPP
     NSQKVPPKDR QWRQDHRLTK HVQFLQRLSG LRSGFEESLC QDGDVVWDSV VQLLDCVVED
     FRQAHTGQPL RHPEQLHNAI QVVAQTLSPG GARQGFPVQH FSRVEDLLKE MVNLLLTNQQ
     LNAFSVQDSL SDCLLALGGN CCITRTPLIQ LLMSQIIQLA QQLRDACEKS REEHEHHQVD
     WVCYQNSFYL FWLLERLAQD TDNRVNQELV VRLETKAFPL ADEFSLFSLY MWRIGGLFRA
     GDS