MEI4_SCHPO
ID MEI4_SCHPO Reviewed; 517 AA.
AC O13606;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 151.
DE RecName: Full=Meiosis-specific transcription factor mei4;
GN Name=mei4; ORFNames=pi013, SPBC32H8.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=9528784; DOI=10.1128/mcb.18.4.2118;
RA Horie S., Watanabe Y., Tanaka K., Nishiwaki S., Fujioka H., Abe H.,
RA Yamamoto M., Shimoda C.;
RT "The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific
RT transcription factor containing a forkhead DNA-binding domain.";
RL Mol. Cell. Biol. 18:2118-2129(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Functions as a meiosis-specific transcription factor. Binds
CC to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6
CC gene.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AB012695; BAA25402.1; -; Genomic_DNA.
DR EMBL; AB004534; BAA21390.1; -; Genomic_DNA.
DR EMBL; CU329671; CAC37501.1; -; Genomic_DNA.
DR PIR; T43358; T43358.
DR RefSeq; NP_595617.1; NM_001021512.2.
DR AlphaFoldDB; O13606; -.
DR SMR; O13606; -.
DR BioGRID; 276773; 38.
DR DIP; DIP-59802N; -.
DR IntAct; O13606; 3.
DR STRING; 4896.SPBC32H8.11.1; -.
DR iPTMnet; O13606; -.
DR PaxDb; O13606; -.
DR PRIDE; O13606; -.
DR EnsemblFungi; SPBC32H8.11.1; SPBC32H8.11.1:pep; SPBC32H8.11.
DR GeneID; 2540241; -.
DR KEGG; spo:SPBC32H8.11; -.
DR PomBase; SPBC32H8.11; mei4.
DR VEuPathDB; FungiDB:SPBC32H8.11; -.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_526931_0_0_1; -.
DR InParanoid; O13606; -.
DR OMA; TWIRNTF; -.
DR Reactome; R-SPO-3232118; SUMOylation of transcription factors.
DR Reactome; R-SPO-9018519; Estrogen-dependent gene expression.
DR PRO; PR:O13606; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0010673; P:positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IMP:PomBase.
DR GO; GO:0110044; P:regulation of cell cycle switching, mitotic to meiotic cell cycle; IMP:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010672; P:regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IMP:PomBase.
DR GO; GO:0110046; P:signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle; IMP:PomBase.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Activator; DNA-binding; Meiosis; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..517
FT /note="Meiosis-specific transcription factor mei4"
FT /id="PRO_0000091906"
FT DNA_BIND 81..172
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 170..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57685 MW; 05D912F04525C759 CRC64;
MVENQGNVEA HGKPKKVILS LSLKESSKIN DSQNVSNVSS KEKCETEALL REENKENLSS
DSIRQMIFGD EMAGFVDTGE KPPCSYATLI GLAILQSHNK QLTLSGIYTW IRNTFRYYLN
HDGGWQNSIR HNLSLNKAFI KVEKPKGKTL KGHYWTIDPD HMQNFVSVRL HRSHSTDSNS
KKRPSSKCHE IKPLTTREIP LARKRSRLNS FNSSTSTSGS SSNVAAEVSN DASQPSNQDS
SLNSNIVKPP LPPSNVQSNS SSSENVPKPN AETQEDLPTI DAHESSLYEN VNDSRLYEVP
ACRNMALNTG YSDADPGYLR TSFRSNSHNS LPYSANEEED VLQADFLVSQ QSSMVSSYVS
SRDPHSMPYY RREPIPLRPS SRFYEYTRPT YGRTDTSCSA PGAFCSTQIN SPSSYINYSK
CAPSSPTLSL QKHREHVKSL LYVPDLTPSF DGSDPWNPSS QLLSEPLFDQ HSFQSSLDDL
MSVTCFRDSP ELNHESSGYS SAPLMPSNRA FINDFSL
