ID   ARHG9_PONAB             Reviewed;         564 AA.
AC   Q5RDK0;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Rho guanine nucleotide exchange factor 9;
DE   AltName: Full=Collybistin;
DE   AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 9;
GN   Name=ARHGEF9;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for CDC42.
CC       Promotes formation of GPHN clusters (By similarity).
CC       {ECO:0000250|UniProtKB:Q9QX73}.
CC   -!- SUBUNIT: Interacts with GPHN. {ECO:0000250|UniProtKB:Q9QX73}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QX73}.
CC       Postsynaptic density {ECO:0000250|UniProtKB:Q3UTH8}.
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DR   EMBL; CR857907; CAH90157.1; -; mRNA.
DR   RefSeq; NP_001125046.1; NM_001131574.1.
DR   AlphaFoldDB; Q5RDK0; -.
DR   BMRB; Q5RDK0; -.
DR   SMR; Q5RDK0; -.
DR   STRING; 9601.ENSPPYP00000022845; -.
DR   PRIDE; Q5RDK0; -.
DR   GeneID; 100171927; -.
DR   KEGG; pon:100171927; -.
DR   CTD; 23229; -.
DR   eggNOG; KOG3519; Eukaryota.
DR   InParanoid; Q5RDK0; -.
DR   OrthoDB; 428887at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11975; SH3_ARHGEF9; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035728; ARHGEF9_SH3.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein;
KW   Reference proteome; SH3 domain; Synapse.
FT   CHAIN           1..564
FT                   /note="Rho guanine nucleotide exchange factor 9"
FT                   /id="PRO_0000253897"
FT   DOMAIN          8..67
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          103..287
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          318..425
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          100..110
FT                   /note="Interaction with GPHN"
FT                   /evidence="ECO:0000250"
FT   REGION          451..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         502
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UTH8"
SQ   SEQUENCE   564 AA;  66253 MW;  8CB2CDC82DB8E6ED CRC64;
     MTLLITGDSI VSAEAVWDHA TMANRELAFK AGDVIKVLDA SNKDWWWGQI DDEEGWFPAS
     FVRLWVNQED EVEEGPSDVQ NGHLDPNSDC LCLGRPLQNR DQMRANVINE IMSTERHYIK
     HLKDICEGYL KQCRKRRDMF SDEQLKVIFG NIEDIYRFQM GFVRDLEKQY NNDDPHLSEI
     GPCFLEHQDG FWIYSEYCNN HLDACMELSK LMKDSRYQHF FEACRLLQQM IDIAIDGFLL
     TPVQKICKYP LQLAELLKYT AQDHSDYRYV AAALAVMRNV TQQINERKRR LENIDKIAQW
     QASVLDWEGE DILDRSSELI YTGEMAWIYQ PYGRNQQRVF FLFDHQMVLC KKDLIRRDIL
     YYKGRIDMDK YEVVDIEDGR DDDFNVSMKN AFKLHNKETE EIHLFFAKKL EEKIRWLRAF
     REERKMVQED EKIGFEISEN QKRQAAMTVR KVPKQKGVNS ARSVPPSYPP PQDPLNHGQY
     LVPDGIAQSQ VFEFTEPKRS QSPFWQNFSR YCEGIKKPNR SKRVSDYDDA GVDFCSGNIL
     HSGCFFYHWG FPCCSTAGSL QFCI