MEIG1_HUMAN
ID MEIG1_HUMAN Reviewed; 88 AA.
AC Q5JSS6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Meiosis expressed gene 1 protein homolog;
GN Name=MEIG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- FUNCTION: Essential for spermiogenesis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PACRG. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5JSS6; Q96M98-2: PACRG; NbExp=5; IntAct=EBI-18583441, EBI-11945452;
CC -!- SIMILARITY: Belongs to the MEIG1 family. {ECO:0000305}.
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DR EMBL; AL360083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31151.1; -.
DR RefSeq; NP_001074305.1; NM_001080836.2.
DR PDB; 6NDU; X-ray; 2.10 A; B=1-88.
DR PDB; 6NEP; X-ray; 2.10 A; B=1-88.
DR PDB; 6UCC; X-ray; 2.60 A; B=1-88.
DR PDBsum; 6NDU; -.
DR PDBsum; 6NEP; -.
DR PDBsum; 6UCC; -.
DR AlphaFoldDB; Q5JSS6; -.
DR SMR; Q5JSS6; -.
DR BioGRID; 569980; 3.
DR IntAct; Q5JSS6; 1.
DR STRING; 9606.ENSP00000384334; -.
DR iPTMnet; Q5JSS6; -.
DR PhosphoSitePlus; Q5JSS6; -.
DR BioMuta; MEIG1; -.
DR MassIVE; Q5JSS6; -.
DR PaxDb; Q5JSS6; -.
DR PeptideAtlas; Q5JSS6; -.
DR PRIDE; Q5JSS6; -.
DR ProteomicsDB; 63170; -.
DR Antibodypedia; 51531; 85 antibodies from 18 providers.
DR DNASU; 644890; -.
DR Ensembl; ENST00000378240.1; ENSP00000367486.1; ENSG00000197889.10.
DR Ensembl; ENST00000407572.6; ENSP00000384334.1; ENSG00000197889.10.
DR GeneID; 644890; -.
DR KEGG; hsa:644890; -.
DR MANE-Select; ENST00000407572.6; ENSP00000384334.1; NM_001080836.3; NP_001074305.1.
DR UCSC; uc009xjk.1; human.
DR CTD; 644890; -.
DR DisGeNET; 644890; -.
DR GeneCards; MEIG1; -.
DR HGNC; HGNC:23429; MEIG1.
DR HPA; ENSG00000197889; Tissue enhanced (fallopian tube, testis).
DR MIM; 614174; gene.
DR neXtProt; NX_Q5JSS6; -.
DR OpenTargets; ENSG00000197889; -.
DR PharmGKB; PA134895701; -.
DR VEuPathDB; HostDB:ENSG00000197889; -.
DR eggNOG; ENOG502S7BQ; Eukaryota.
DR GeneTree; ENSGT00390000013550; -.
DR HOGENOM; CLU_160103_0_0_1; -.
DR InParanoid; Q5JSS6; -.
DR OMA; QVKQVDM; -.
DR OrthoDB; 1489247at2759; -.
DR PhylomeDB; Q5JSS6; -.
DR TreeFam; TF329080; -.
DR PathwayCommons; Q5JSS6; -.
DR SignaLink; Q5JSS6; -.
DR BioGRID-ORCS; 644890; 14 hits in 989 CRISPR screens.
DR GenomeRNAi; 644890; -.
DR Pharos; Q5JSS6; Tdark.
DR PRO; PR:Q5JSS6; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5JSS6; protein.
DR Bgee; ENSG00000197889; Expressed in bronchial epithelial cell and 96 other tissues.
DR Genevisible; Q5JSS6; HS.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0002177; C:manchette; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1905198; P:manchette assembly; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0007288; P:sperm axoneme assembly; IEA:Ensembl.
DR InterPro; IPR020186; Meiosis-expressed_gene_1.
DR PANTHER; PTHR17008; PTHR17008; 1.
DR Pfam; PF15163; Meiosis_expr; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Differentiation; Reference proteome; Spermatogenesis.
FT CHAIN 1..88
FT /note="Meiosis expressed gene 1 protein homolog"
FT /id="PRO_0000313025"
FT VARIANT 9
FT /note="K -> T (in dbSNP:rs4750568)"
FT /id="VAR_053979"
FT STRAND 9..13
FT /evidence="ECO:0007829|PDB:6NEP"
FT HELIX 19..29
FT /evidence="ECO:0007829|PDB:6NEP"
FT HELIX 35..41
FT /evidence="ECO:0007829|PDB:6NEP"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:6NEP"
FT STRAND 58..60
FT /evidence="ECO:0007829|PDB:6NEP"
FT STRAND 66..68
FT /evidence="ECO:0007829|PDB:6NEP"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:6NEP"
FT STRAND 84..87
FT /evidence="ECO:0007829|PDB:6NEP"
SQ SEQUENCE 88 AA; 10795 MW; B560DAFFB60DC274 CRC64;
MASSDVKPKS VSHAKKWSEE IENLYRFQQA GYRDETEYRQ VKQVSMVDRW PETGYVKKLQ
RRDNTFYYYN KQRECDDKEV HKVKIYAY
