ID   MEIOB_MACFA             Reviewed;         471 AA.
AC   Q4R8G6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Meiosis-specific with OB domain-containing protein;
DE            EC=3.1.-.-;
GN   Name=MEIOB; ORFNames=QtsA-12515;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Single-stranded DNA-binding protein required for homologous
CC       recombination in meiosis I. Required for double strand breaks (DSBs)
CC       repair and crossover formation and promotion of faithful and complete
CC       synapsis. Not required for the initial loading of recombinases but
CC       required to maintain a proper number of RAD51 and DMC1 foci after the
CC       zygotene stage. May act by ensuring the stabilization of recombinases,
CC       which is required for successful homology search and meiotic
CC       recombination. Displays Single-stranded DNA 3'-5' exonuclease activity
CC       in vitro. {ECO:0000250|UniProtKB:Q9D513}.
CC   -!- SUBUNIT: Component of a multiprotein complex with RPA2 and SPATA22.
CC       Interacts with the complex BRME1:HSF2BP:BRCA2.
CC       {ECO:0000250|UniProtKB:Q9D513}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D513}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9D513}. Chromosome
CC       {ECO:0000250|UniProtKB:Q9D513}. Note=Co-localizes with the RPA complex
CC       on meiotic chromosome axes. Accumulates on resected DNA. Localization
CC       is dependent on SPATA22. {ECO:0000250|UniProtKB:Q9D513}.
CC   -!- SIMILARITY: Belongs to the MEIOB family. {ECO:0000305}.
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DR   EMBL; AB168486; BAE00606.1; -; mRNA.
DR   RefSeq; NP_001271876.1; NM_001284947.1.
DR   AlphaFoldDB; Q4R8G6; -.
DR   SMR; Q4R8G6; -.
DR   STRING; 9541.XP_005590957.1; -.
DR   PRIDE; Q4R8G6; -.
DR   GeneID; 101865668; -.
DR   CTD; 254528; -.
DR   eggNOG; KOG0851; Eukaryota.
DR   OrthoDB; 615895at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0008310; F:single-stranded DNA 3'-5' exodeoxyribonuclease activity; ISS:UniProtKB.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0007144; P:female meiosis I; ISS:UniProtKB.
DR   GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISS:UniProtKB.
DR   GO; GO:0007140; P:male meiotic nuclear division; ISS:UniProtKB.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 3.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR031657; REPA_OB_2.
DR   Pfam; PF16900; REPA_OB_2; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
PE   2: Evidence at transcript level;
KW   Chromosome; Cytoplasm; DNA-binding; Exonuclease; Hydrolase; Meiosis;
KW   Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..471
FT                   /note="Meiosis-specific with OB domain-containing protein"
FT                   /id="PRO_0000337135"
FT   DNA_BIND        167..272
FT                   /note="OB"
SQ   SEQUENCE   471 AA;  52930 MW;  DCCCB74937E54357 CRC64;
     MANSFATRTF TTLSDLQPNM ANLKVIGVVI GKTDVKGFPD RKNIGSERYT FSFTIRDSPA
     HFVNAASWGN EDYIKSLSDS FRVGDCVIIE NPLIQRKEIE REEKFSPATP SNCKLLLSEN
     HSTVKVCSSY EVDTKLLSLI HLPVKESHDY YSLGDIVANG HSLNGRIINV LAAVKSVGEP
     KYFTTSDRRK GQRCEVRLYD ETEFSFAMTC WDNESILLAQ SWMPRETVIF VSDVRISFDK
     FRNCMTATVI SKTIITTNPE TPEANILLNF IRENKETNVL DDEIESYFKE SINLSTIVDV
     YTVEQLKGKA LKNEGKADPS YGILYAYIST LNIDDETTKV VRNRCSTCGY IVNEASNMCT
     ICNKNSLDFK SVFLSFDMLI DLTDHTGTLH SCSLTGSVAE ETLGCTVNEF LAMTDEQKTA
     LKWQFLLERS KIYLKFVVSH RARSGLKISV LSCKLADPTE ASRNLSGQTR V