MEIOC_HUMAN
ID MEIOC_HUMAN Reviewed; 952 AA.
AC A2RUB1; B4DXJ2; B5MD93; B9EGQ6; C4AM97; Q4G0Y1; Q8IVZ7; Q8NA45;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Meiosis-specific coiled-coil domain-containing protein MEIOC {ECO:0000305};
DE AltName: Full=Meiosis-specific with coiled-coil domain protein {ECO:0000303|PubMed:26742488, ECO:0000312|HGNC:HGNC:26670};
GN Name=MEIOC {ECO:0000312|HGNC:HGNC:26670}; Synonyms=C17orf104;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 585-952 (ISOFORMS 1/2), AND VARIANT THR-320.
RC TISSUE=Liver, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 167-920 (ISOFORM 2), AND VARIANT
RP THR-320.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=26742488; DOI=10.1038/ncomms10324;
RA Abby E., Tourpin S., Ribeiro J., Daniel K., Messiaen S., Moison D.,
RA Guerquin J., Gaillard J.C., Armengaud J., Langa F., Toth A., Martini E.,
RA Livera G.;
RT "Implementation of meiosis prophase I programme requires a conserved
RT retinoid-independent stabilizer of meiotic transcripts.";
RL Nat. Commun. 7:10324-10324(2016).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=28380054; DOI=10.1371/journal.pgen.1006704;
RA Soh Y.Q.S., Mikedis M.M., Kojima M., Godfrey A.K., de Rooij D.G.,
RA Page D.C.;
RT "Meioc maintains an extended meiotic prophase I in mice.";
RL PLoS Genet. 13:E1006704-E1006704(2017).
CC -!- FUNCTION: Is required for meiosis completion in both male and female
CC germ cells. Confers stability to numerous meiotic mRNAs in gonads
CC allowing proper initiation and progression into meiosis prophase I. The
CC function may involve YTHDC2 and is independent of induction by retinoic
CC acid (RA). Maintains an extended meiotic prophase I by properly
CC promoting the transition from a mitotic to a meiotic cell cycle program
CC by binding transcripts through its interaction with YTHDC2 that
CC regulate the mitotic cell cycle. {ECO:0000250|UniProtKB:A2AG06}.
CC -!- SUBUNIT: Interacts with YTHDC2; binds transcript that regulate the
CC mitotic cell cycle inhibiting progression into metaphase, thereby
CC allowing meiotic prophase to proceed normally.
CC {ECO:0000250|UniProtKB:A2AG06}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AG06}. Nucleus
CC {ECO:0000250|UniProtKB:A2AG06}. Note=at late pachytene a fraction is
CC nuclear. {ECO:0000250|UniProtKB:A2AG06}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A2RUB1-4; Sequence=Displayed;
CC Name=2;
CC IsoId=A2RUB1-2; Sequence=VSP_038971;
CC Name=3;
CC IsoId=A2RUB1-1; Sequence=VSP_038971, VSP_038972, VSP_038973;
CC Name=4;
CC IsoId=A2RUB1-5; Sequence=VSP_038972, VSP_038973;
CC -!- TISSUE SPECIFICITY: Expressed in fetal ovaries (PubMed:26742488).
CC Expressed in testis (PubMed:28380054). {ECO:0000269|PubMed:26742488,
CC ECO:0000269|PubMed:28380054}.
CC -!- DEVELOPMENTAL STAGE: Expression first detected in wpf (week post-
CC fertilization) 11 and is highest in wpf 22.
CC {ECO:0000269|PubMed:26742488}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35159.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI32823.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI36643.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC091152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035159; AAH35159.1; ALT_INIT; mRNA.
DR EMBL; BC041481; AAH41481.2; -; mRNA.
DR EMBL; BC132822; AAI32823.1; ALT_INIT; mRNA.
DR EMBL; BC136642; AAI36643.1; ALT_INIT; mRNA.
DR EMBL; AK093167; BAC04083.1; -; mRNA.
DR EMBL; AK302001; BAG63404.1; -; mRNA.
DR CCDS; CCDS45703.2; -. [A2RUB1-4]
DR RefSeq; NP_001138552.2; NM_001145080.2. [A2RUB1-4]
DR AlphaFoldDB; A2RUB1; -.
DR SMR; A2RUB1; -.
DR BioGRID; 129749; 11.
DR IntAct; A2RUB1; 5.
DR STRING; 9606.ENSP00000386452; -.
DR iPTMnet; A2RUB1; -.
DR PhosphoSitePlus; A2RUB1; -.
DR BioMuta; MEIOC; -.
DR EPD; A2RUB1; -.
DR MassIVE; A2RUB1; -.
DR MaxQB; A2RUB1; -.
DR PaxDb; A2RUB1; -.
DR PeptideAtlas; A2RUB1; -.
DR PRIDE; A2RUB1; -.
DR ProteomicsDB; 503; -. [A2RUB1-4]
DR ProteomicsDB; 504; -. [A2RUB1-1]
DR ProteomicsDB; 505; -. [A2RUB1-2]
DR ProteomicsDB; 506; -. [A2RUB1-5]
DR Antibodypedia; 17505; 40 antibodies from 15 providers.
DR DNASU; 284071; -.
DR Ensembl; ENST00000409122.7; ENSP00000386452.1; ENSG00000180336.18. [A2RUB1-4]
DR Ensembl; ENST00000409464.1; ENSP00000386586.1; ENSG00000180336.18. [A2RUB1-1]
DR GeneID; 284071; -.
DR KEGG; hsa:284071; -.
DR MANE-Select; ENST00000409122.7; ENSP00000386452.1; NM_001145080.3; NP_001138552.2.
DR UCSC; uc002igz.4; human. [A2RUB1-4]
DR CTD; 284071; -.
DR GeneCards; MEIOC; -.
DR HGNC; HGNC:26670; MEIOC.
DR HPA; ENSG00000180336; Tissue enriched (testis).
DR MIM; 616934; gene.
DR neXtProt; NX_A2RUB1; -.
DR OpenTargets; ENSG00000180336; -.
DR PharmGKB; PA165431498; -.
DR VEuPathDB; HostDB:ENSG00000180336; -.
DR eggNOG; ENOG502QPMP; Eukaryota.
DR GeneTree; ENSGT00390000003267; -.
DR HOGENOM; CLU_015343_0_0_1; -.
DR InParanoid; A2RUB1; -.
DR OMA; TSFYDCY; -.
DR OrthoDB; 127098at2759; -.
DR PhylomeDB; A2RUB1; -.
DR TreeFam; TF313161; -.
DR PathwayCommons; A2RUB1; -.
DR SignaLink; A2RUB1; -.
DR BioGRID-ORCS; 284071; 24 hits in 1037 CRISPR screens.
DR GenomeRNAi; 284071; -.
DR Pharos; A2RUB1; Tdark.
DR PRO; PR:A2RUB1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A2RUB1; protein.
DR Bgee; ENSG00000180336; Expressed in buccal mucosa cell and 99 other tissues.
DR ExpressionAtlas; A2RUB1; baseline and differential.
DR Genevisible; A2RUB1; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0007144; P:female meiosis I; IBA:GO_Central.
DR GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0007141; P:male meiosis I; IBA:GO_Central.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR GO; GO:0048599; P:oocyte development; ISS:UniProtKB.
DR GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR GO; GO:0007130; P:synaptonemal complex assembly; IEA:Ensembl.
DR InterPro; IPR027963; MEIOC.
DR PANTHER; PTHR33861; PTHR33861; 1.
DR Pfam; PF15189; MEIOC; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..952
FT /note="Meiosis-specific coiled-coil domain-containing
FT protein MEIOC"
FT /id="PRO_0000325800"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..166
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_038971"
FT VAR_SEQ 821..825
FT /note="VTLLG -> SCKNR (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038972"
FT VAR_SEQ 826..952
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038973"
FT VARIANT 311
FT /note="M -> L (in dbSNP:rs8073475)"
FT /id="VAR_039917"
FT VARIANT 320
FT /note="N -> T (in dbSNP:rs9907151)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_039918"
FT CONFLICT 496
FT /note="N -> S (in Ref. 3; BAG63404)"
FT /evidence="ECO:0000305"
FT CONFLICT 552
FT /note="G -> S (in Ref. 3; BAC04083)"
FT /evidence="ECO:0000305"
FT CONFLICT 920
FT /note="V -> H (in Ref. 3; BAG63404)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 952 AA; 107559 MW; 7455073FCEBEE419 CRC64;
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF GSVMLTGSAS
FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW STYGDDIKQP SNSQISIKNR
IQTERNDYGS ETDLYGLVSN ILEEQDKSQP YFAEGTCSSN LKSVWPMNTS RFADHHDLLT
ETKRPIDTVI SQQAFYSDES VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS
RSDHSNCHNI QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL
EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS KKLANGTPET
PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH LTEKQFAKEA VFTADFGLTS
EYGLKPHTAC PANDFANVTE KQQFAKPDPP HSEYFKSVNL LSNSATSSGG INLNRPTWMN
VQTKNNTPIP YRNQGNLMKL NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP
SAFSSFDFSY SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII
ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR GGDNSRVNRT
QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV VPLLDSYDLL SYDDLSHLYP
YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP ASELHIRLEE CCEQWRALEK ERKKTELALA
KNYPGKKVSS TNNTPVPRLT SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS
TALDRHLESI HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT
ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN KH
