MEIOS_HUMAN
ID MEIOS_HUMAN Reviewed; 638 AA.
AC C9JSJ3;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Meiosis initiator protein {ECO:0000305};
DE AltName: Full=Basic helix-loop-helix and HMG box domain-containing protein 1;
GN Name=MEIOSIN {ECO:0000312|HGNC:HGNC:44318}; Synonyms=BHMG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: Gatekeeper of meiotic initiation in both male and female germ
CC cells. In complex with STRA8, directly activates the transcription of a
CC subset of critical meiotic genes playing a central role in cell-cycle
CC switching from mitosis to meiosis. Temporal expression of MEIOSIN is
CC required for meiotic entry decision.
CC {ECO:0000250|UniProtKB:A0A5K7RLP0}.
CC -!- SUBUNIT: Interacts with STRA8. {ECO:0000250|UniProtKB:A0A5K7RLP0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A5K7RLP0}.
CC -!- CAUTION: Contains a degenerate basic motif not likely to bind DNA.
CC {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC074212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS82368.1; -.
DR RefSeq; NP_001297053.1; NM_001310124.1.
DR AlphaFoldDB; C9JSJ3; -.
DR SMR; C9JSJ3; -.
DR IntAct; C9JSJ3; 1.
DR STRING; 9606.ENSP00000402674; -.
DR GlyGen; C9JSJ3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; C9JSJ3; -.
DR PhosphoSitePlus; C9JSJ3; -.
DR BioMuta; BHMG1; -.
DR MassIVE; C9JSJ3; -.
DR PaxDb; C9JSJ3; -.
DR PRIDE; C9JSJ3; -.
DR Antibodypedia; 65055; 12 antibodies from 4 providers.
DR DNASU; 388553; -.
DR Ensembl; ENST00000457052.3; ENSP00000402674.3; ENSG00000237452.3.
DR GeneID; 388553; -.
DR KEGG; hsa:388553; -.
DR MANE-Select; ENST00000457052.3; ENSP00000402674.3; NM_001310124.2; NP_001297053.1.
DR UCSC; uc021uwa.2; human.
DR CTD; 388553; -.
DR DisGeNET; 388553; -.
DR GeneCards; MEIOSIN; -.
DR HGNC; HGNC:44318; MEIOSIN.
DR HPA; ENSG00000237452; Tissue enriched (testis).
DR neXtProt; NX_C9JSJ3; -.
DR OpenTargets; ENSG00000237452; -.
DR VEuPathDB; HostDB:ENSG00000237452; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00570000080851; -.
DR HOGENOM; CLU_428906_0_0_1; -.
DR InParanoid; C9JSJ3; -.
DR OMA; KQYIRAC; -.
DR OrthoDB; 1031202at2759; -.
DR PathwayCommons; C9JSJ3; -.
DR BioGRID-ORCS; 388553; 0 hits in 26 CRISPR screens.
DR ChiTaRS; BHMG1; human.
DR GenomeRNAi; 388553; -.
DR Pharos; C9JSJ3; Tdark.
DR PRO; PR:C9JSJ3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; C9JSJ3; protein.
DR Bgee; ENSG00000237452; Expressed in right testis and 3 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0090427; P:activation of meiosis; ISS:UniProtKB.
DR GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Meiosis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..638
FT /note="Meiosis initiator protein"
FT /id="PRO_0000430831"
FT DOMAIN 62..116
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DNA_BIND 540..608
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..75
FT /note="Basic motif; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 76..116
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 138..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 70198 MW; EFE2D9D5B3A72ACE CRC64;
MFGSSRYLGS SEQPRANSLG PSDRTLVLCS LVEGEDKVNP SEPHGLRMEE KWLLKGKLRN
QRNQNKLLSP NKKQRKNHTS KLQELALLLP IALKTGTKKL TKKEILVHVL QYIQYLQRNI
DAAKALFKCH ITTGEGGLAG LGQKPAWGPA RRRRHSTPSS SPSSQKSCLQ GACQKPRKKK
LTQASESQTR TPKPRRSLAL NKPEKLVAPS PDQKGSGTGG TTTPPRCPDS CGHPRPASSS
PPGDRKGGQS QLTLLDLAED TIHCDISSCW CQGSVQDDAP FPALLAQEDV ARIHFLNKTQ
PHPRQKLVFY DSSEDVDKGS LDADPWLPAW TPENSPQGSP LFLGPPQIDV WSGTGHPSEI
LGLSPSLFSS PGKLLPDEIL EDDMEYLTQA AFFEEVCLDL ESSPSAYTQE APQEKDTASK
APKDPPESHS LHRSSVSLDH CYLSLSGNSK APSSSSSSSS SSSSSEDSDS EPLWKQREDM
QANPVGTPGS SEEDEDTTWT PTRLASPLLA AEKKATKGQV ARAPVKPKEK KKGPCPPQMK
KKCVNGFIMF CRMNRKQYIR SCPGTASTAA TKELAQLWRV MTQQERRPYC TKARRFSRQH
NRIVKQDGSS SEAEDWETPK PFYQLLAEKA LPLPPHLQ
