ARHGA_HUMAN
ID ARHGA_HUMAN Reviewed; 1369 AA.
AC O15013; O14665; Q2KHR8; Q68D55; Q8IWD9; Q8IY77;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 4.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Rho guanine nucleotide exchange factor 10;
GN Name=ARHGEF10; Synonyms=KIAA0294;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Brain;
RX PubMed=9205841; DOI=10.1093/dnares/4.2.141;
RA Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. VII. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 4:141-150(1997).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Duodenum, Prostate, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 353-1369 (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=9314494; DOI=10.1101/gr.7.9.887;
RA Ranta S., Lehesjoki A.-E., de Fatima Bonaldo M., Knowles J.A.,
RA Hirvasniemi A., Ross B., de Jong P.J., Soares M.B., de la Chapelle A.,
RA Gilliam T.C.;
RT "High-resolution mapping and transcript identification at the progressive
RT epilepsy with mental retardation locus on chromosome 8p.";
RL Genome Res. 7:887-896(1997).
RN [7]
RP FUNCTION, AND VARIANT SNCV ILE-357.
RX PubMed=14508709; DOI=10.1086/378159;
RA Verhoeven K., De Jonghe P., Van de Putte T., Nelis E., Zwijsen A.,
RA Verpoorten N., De Vriendt E., Jacobs A., Van Gerwen V., Francis A.,
RA Ceuterick C., Huylebroeck D., Timmerman V.;
RT "Slowed conduction and thin myelination of peripheral nerves associated
RT with mutant rho Guanine-nucleotide exchange factor 10.";
RL Am. J. Hum. Genet. 73:926-932(2003).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1287, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-379, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-379, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP METHYLATION AT GLN-1338, AND MUTAGENESIS OF GLN-1338.
RX PubMed=26797129; DOI=10.1074/jbc.m115.711952;
RA Kusevic D., Kudithipudi S., Jeltsch A.;
RT "Substrate specificity of the HEMK2 protein glutamine methyltransferase and
RT identification of novel substrates.";
RL J. Biol. Chem. 291:6124-6133(2016).
RN [12]
RP VARIANT HIS-227.
RX PubMed=24627108; DOI=10.1007/s00415-014-7289-8;
RA Schabhuettl M., Wieland T., Senderek J., Baets J., Timmerman V.,
RA De Jonghe P., Reilly M.M., Stieglbauer K., Laich E., Windhager R., Erwa W.,
RA Trajanoski S., Strom T.M., Auer-Grumbach M.;
RT "Whole-exome sequencing in patients with inherited neuropathies: outcome
RT and challenges.";
RL J. Neurol. 261:970-982(2014).
CC -!- FUNCTION: May play a role in developmental myelination of peripheral
CC nerves. {ECO:0000269|PubMed:14508709}.
CC -!- INTERACTION:
CC O15013; O15066: KIF3B; NbExp=3; IntAct=EBI-2515636, EBI-3931791;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=O15013-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O15013-6; Sequence=VSP_040757;
CC Name=3;
CC IsoId=O15013-7; Sequence=VSP_040754, VSP_040756;
CC Name=4;
CC IsoId=O15013-4; Sequence=VSP_010704;
CC Name=5;
CC IsoId=O15013-5; Sequence=VSP_040754, VSP_040755;
CC -!- PTM: Methylated at Gln-1338 by N6AMT1. {ECO:0000269|PubMed:26797129}.
CC -!- DISEASE: Slowed nerve conduction velocity (SNCV) [MIM:608236]: Affected
CC individuals present a reduction in nerve conduction velocities without
CC any clinical signs of peripheral or central nervous system dysfunction.
CC SNCV inheritance is autosomal dominant. {ECO:0000269|PubMed:14508709}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH36809.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=AAH40474.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=BAA20754.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAH18365.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; CR749570; CAH18365.1; ALT_TERM; mRNA.
DR EMBL; AB002292; BAA20754.2; ALT_INIT; mRNA.
DR EMBL; AC019257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036809; AAH36809.1; ALT_SEQ; mRNA.
DR EMBL; BC040474; AAH40474.1; ALT_SEQ; mRNA.
DR EMBL; BC112926; AAI12927.1; -; mRNA.
DR EMBL; AF009205; AAB71662.1; -; mRNA.
DR CCDS; CCDS34794.1; -. [O15013-5]
DR CCDS; CCDS78296.1; -. [O15013-6]
DR CCDS; CCDS78297.1; -. [O15013-7]
DR PIR; T03307; T03307.
DR RefSeq; NP_001295081.1; NM_001308152.1. [O15013-7]
DR RefSeq; NP_001295082.1; NM_001308153.1. [O15013-6]
DR RefSeq; NP_055444.2; NM_014629.3. [O15013-5]
DR RefSeq; XP_016869492.1; XM_017014003.1. [O15013-1]
DR AlphaFoldDB; O15013; -.
DR SMR; O15013; -.
DR BioGRID; 114998; 89.
DR IntAct; O15013; 12.
DR STRING; 9606.ENSP00000340297; -.
DR iPTMnet; O15013; -.
DR PhosphoSitePlus; O15013; -.
DR BioMuta; ARHGEF10; -.
DR EPD; O15013; -.
DR jPOST; O15013; -.
DR MassIVE; O15013; -.
DR MaxQB; O15013; -.
DR PaxDb; O15013; -.
DR PeptideAtlas; O15013; -.
DR PRIDE; O15013; -.
DR ProteomicsDB; 48364; -. [O15013-1]
DR ProteomicsDB; 48365; -. [O15013-4]
DR ProteomicsDB; 48366; -. [O15013-5]
DR ProteomicsDB; 48367; -. [O15013-6]
DR ProteomicsDB; 48368; -. [O15013-7]
DR Antibodypedia; 8026; 167 antibodies from 31 providers.
DR DNASU; 9639; -.
DR Ensembl; ENST00000349830.8; ENSP00000340297.3; ENSG00000104728.16. [O15013-5]
DR Ensembl; ENST00000398564.5; ENSP00000381571.1; ENSG00000104728.16. [O15013-1]
DR Ensembl; ENST00000518288.5; ENSP00000431012.1; ENSG00000104728.16. [O15013-6]
DR Ensembl; ENST00000520359.5; ENSP00000427909.1; ENSG00000104728.16. [O15013-7]
DR Ensembl; ENST00000610399.4; ENSP00000481974.1; ENSG00000274726.4. [O15013-1]
DR Ensembl; ENST00000619613.4; ENSP00000477988.1; ENSG00000274726.4. [O15013-5]
DR Ensembl; ENST00000631758.1; ENSP00000488343.1; ENSG00000274726.4. [O15013-7]
DR Ensembl; ENST00000633616.1; ENSP00000488463.1; ENSG00000274726.4. [O15013-6]
DR GeneID; 9639; -.
DR KEGG; hsa:9639; -.
DR MANE-Select; ENST00000349830.8; ENSP00000340297.3; NM_014629.4; NP_055444.2. [O15013-5]
DR UCSC; uc003wpr.4; human. [O15013-1]
DR CTD; 9639; -.
DR DisGeNET; 9639; -.
DR GeneCards; ARHGEF10; -.
DR GeneReviews; ARHGEF10; -.
DR HGNC; HGNC:14103; ARHGEF10.
DR HPA; ENSG00000104728; Low tissue specificity.
DR MalaCards; ARHGEF10; -.
DR MIM; 608136; gene.
DR MIM; 608236; phenotype.
DR neXtProt; NX_O15013; -.
DR OpenTargets; ENSG00000104728; -.
DR Orphanet; 140481; Autosomal dominant slowed nerve conduction velocity.
DR PharmGKB; PA24967; -.
DR VEuPathDB; HostDB:ENSG00000104728; -.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR InParanoid; O15013; -.
DR OMA; EYGNNEG; -.
DR OrthoDB; 67600at2759; -.
DR PhylomeDB; O15013; -.
DR TreeFam; TF331430; -.
DR PathwayCommons; O15013; -.
DR Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR Reactome; R-HSA-9013026; RHOB GTPase cycle.
DR Reactome; R-HSA-9013106; RHOC GTPase cycle.
DR Reactome; R-HSA-9013148; CDC42 GTPase cycle.
DR Reactome; R-HSA-9013149; RAC1 GTPase cycle.
DR SignaLink; O15013; -.
DR SIGNOR; O15013; -.
DR BioGRID-ORCS; 9639; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; ARHGEF10; human.
DR GeneWiki; ARHGEF10; -.
DR GenomeRNAi; 9639; -.
DR Pharos; O15013; Tbio.
DR PRO; PR:O15013; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; O15013; protein.
DR Bgee; ENSG00000104728; Expressed in sural nerve and 94 other tissues.
DR ExpressionAtlas; O15013; baseline and differential.
DR Genevisible; O15013; HS.
DR GO; GO:0005813; C:centrosome; IDA:BHF-UCL.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:BHF-UCL.
DR GO; GO:0019894; F:kinesin binding; IPI:BHF-UCL.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IDA:BHF-UCL.
DR GO; GO:0051298; P:centrosome duplication; IMP:BHF-UCL.
DR GO; GO:0090307; P:mitotic spindle assembly; IMP:BHF-UCL.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IMP:BHF-UCL.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:BHF-UCL.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR030632; ARHGEF10.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; PTHR12877; 1.
DR PANTHER; PTHR12877:SF14; PTHR12877:SF14; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Disease variant;
KW Guanine-nucleotide releasing factor; Methylation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1369
FT /note="Rho guanine nucleotide exchange factor 10"
FT /id="PRO_0000080926"
FT DOMAIN 421..608
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 304..355
FT /evidence="ECO:0000255"
FT COMPBIAS 192..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 180
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C033"
FT MOD_RES 379
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 1287
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 1338
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000269|PubMed:26797129"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9205841"
FT /id="VSP_040754"
FT VAR_SEQ 185
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:9205841"
FT /id="VSP_040755"
FT VAR_SEQ 307..345
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040756"
FT VAR_SEQ 545
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_040757"
FT VAR_SEQ 897..925
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:9314494"
FT /id="VSP_010704"
FT VARIANT 227
FT /note="N -> H (found in a patient with hereditary motor and
FT sensory neuropathy; unknown pathological significance;
FT dbSNP:rs767902219)"
FT /evidence="ECO:0000269|PubMed:24627108"
FT /id="VAR_073288"
FT VARIANT 357
FT /note="T -> I (in SNCV; dbSNP:rs28940281)"
FT /evidence="ECO:0000269|PubMed:14508709"
FT /id="VAR_019118"
FT VARIANT 700
FT /note="V -> I (in dbSNP:rs2294039)"
FT /id="VAR_038603"
FT VARIANT 725
FT /note="V -> I (in dbSNP:rs2294039)"
FT /id="VAR_057188"
FT MUTAGEN 1338
FT /note="Q->R: Abolishes methylation by N6AMT1."
FT /evidence="ECO:0000269|PubMed:26797129"
FT CONFLICT 395
FT /note="L -> F (in Ref. 5; AAI12927)"
FT /evidence="ECO:0000305"
FT CONFLICT 500
FT /note="D -> V (in Ref. 5; AAH40474)"
FT /evidence="ECO:0000305"
FT CONFLICT 1024
FT /note="T -> S (in Ref. 6; AAB71662)"
FT /evidence="ECO:0000305"
FT CONFLICT 1046
FT /note="S -> T (in Ref. 6; AAB71662)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1369 AA; 151612 MW; 6F87869C7C6A5759 CRC64;
MRPPGFLSRA PSLNRAERGI WSCSMDQREP LPPAPAENEM KYDTNNNEEE EGEQFDFDSG
DEIPEADRQA PSAPETGGAG ASEAPAPTGG EDGAGAETTP VAEPTKLVLP MKVNPYSVID
ITPFQEDQPP TPVPSAEEEN VGLHVPCGYL VPVPCGYAVP SNLPLLLPAY SSPVIICATS
LDEEAETPEV TEDRQPNSLS SEEPPTSEDQ VGREDSALAR WAADPANTAW MENPEEAIYD
DVPRENSDSE PDEMIYDDVE NGDEGGNSSL EYGWSSSEFE SYEEQSDSEC KNGIPRSFLR
SNHKKQLSHD LTRLKEHYEK KMRDLMASTV GVVEIQQLRQ KHELKMQKLV KAAKDGTKDG
LERTRAAVKR GRSFIRTKSL IAQDHRSSLE EEQNLFIDVD CKHPEAILTP MPEGLSQQQV
VRRYILGSVV DSEKNYVDAL KRILEQYEKP LSEMEPKVLS ERKLKTVFYR VKEILQCHSL
FQIALASRVS EWDSVEMIGD VFVASFSKSM VLDAYSEYVN NFSTAVAVLK KTCATKPAFL
EFLKQEQEAS PDRTTLYSLM MKPIQRFPQF ILLLQDMLKN TSKGHPDRLP LQMALTELET
LAEKLNERKR DADQRCEVKQ IAKAINERYL NKLLSSGSRY LIRSDDMIET VYNDRGEIVK
TKERRVFMLN DVLMCATVSS RPSHDSRVMS SQRYLLKWSV PLGHVDAIEY GSSAGTGEHS
RHLAVHPPES LAVVANAKPN KVYMGPGQLY QDLQNLLHDL NVIGQITQLI GNLKGNYQNL
NQSVAHDWTS GLQRLILKKE DEIRAADCCR IQLQLPGKQD KSGRPTFFTA VFNTFTPAIK
ESWVNSLQMA KLALEEENHM GWFCVEDDGN HIKKEKHPLL VGHMPVMVAK QQEFKIECAA
YNPEPYLNNE SQPDSFSTAH GFLWIGSCTH QMGQIAIVSF QNSTPKVIEC FNVESRILCM
LYVPVEEKRR EPGAPPDPET PAVRASDVPT ICVGTEEGSI SIYKSSQGSK KVRLQHFFTP
EKSTVMSLAC TSQSLYAGLV NGAVASYARA PDGSWDSEPQ KVIKLGVLPV RSLLMMEDTL
WAASGGQVFI ISVETHAVEG QLEAHQEEGM VISHMAVSGV GIWIAFTSGS TLRLFHTETL
KHLQDINIAT PVHNMLPGHQ RLSVTSLLVC HGLLMVGTSL GVLVALPVPR LQGIPKVTGR
GMVSYHAHNS PVKFIVLATA LHEKDKDKSR DSLAPGPEPQ DEDQKDALPS GGAGSSLSQG
DPDAAIWLGD SLGSMTQKSD LSSSSGSLSL SHGSSSLEHR SEDSTIYDLL KDPVSLRSKA
RRAKKAKASS ALVVCGGQGH RRVHRKARQP HQEELAPTVM VWQIPLLNI
