MEIS3_HUMAN
ID MEIS3_HUMAN Reviewed; 375 AA.
AC Q99687; A8K1N5; Q6NT73; Q8TC66; Q9NPW2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 3.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Homeobox protein Meis3;
DE AltName: Full=Meis1-related protein 2;
GN Name=MEIS3; Synonyms=MRG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Salivary gland, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 168-375 (ISOFORMS 1/3).
RX PubMed=9049632; DOI=10.1101/gr.7.2.142;
RA Steelman S., Moskow J.J., Muzynski K., North C., Druck T., Montgomery J.C.,
RA Huebner K., Daar I.O., Buchberg A.M.;
RT "Identification of a conserved family of Meis1-related homeobox genes.";
RL Genome Res. 7:142-156(1997).
CC -!- FUNCTION: Transcriptional regulator which directly modulates PDPK1
CC expression, thus promoting survival of pancreatic beta-cells. Also
CC regulates expression of NDFIP1, BNIP3, and CCNG1.
CC {ECO:0000250|UniProtKB:P97368}.
CC -!- INTERACTION:
CC Q99687-3; P0C7T5: ATXN1L; NbExp=3; IntAct=EBI-18582591, EBI-8624731;
CC Q99687-3; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-18582591, EBI-744311;
CC Q99687-3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-18582591, EBI-744099;
CC Q99687-3; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-18582591, EBI-1752811;
CC Q99687-3; Q8TC76: FAM110B; NbExp=3; IntAct=EBI-18582591, EBI-2558383;
CC Q99687-3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-18582591, EBI-7225287;
CC Q99687-3; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-18582591, EBI-6658203;
CC Q99687-3; O14964: HGS; NbExp=3; IntAct=EBI-18582591, EBI-740220;
CC Q99687-3; Q96HW7-3: INTS4; NbExp=3; IntAct=EBI-18582591, EBI-12240836;
CC Q99687-3; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-18582591, EBI-726510;
CC Q99687-3; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-18582591, EBI-11742507;
CC Q99687-3; O95983-2: MBD3; NbExp=3; IntAct=EBI-18582591, EBI-11978579;
CC Q99687-3; P48426: PIP4K2A; NbExp=3; IntAct=EBI-18582591, EBI-3924422;
CC Q99687-3; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-18582591, EBI-1567797;
CC Q99687-3; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-18582591, EBI-11974061;
CC Q99687-3; P51687: SUOX; NbExp=3; IntAct=EBI-18582591, EBI-3921347;
CC Q99687-3; O95988: TCL1B; NbExp=3; IntAct=EBI-18582591, EBI-727338;
CC Q99687-3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-18582591, EBI-11741437;
CC Q99687-3; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-18582591, EBI-10241197;
CC Q99687-3; Q14119: VEZF1; NbExp=3; IntAct=EBI-18582591, EBI-11980193;
CC Q99687-3; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-18582591, EBI-740727;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P97368}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q99687-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99687-2; Sequence=VSP_012893;
CC Name=3;
CC IsoId=Q99687-3; Sequence=VSP_012892;
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
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DR EMBL; AK289950; BAF82639.1; -; mRNA.
DR EMBL; AL359938; CAB95771.1; -; mRNA.
DR EMBL; CR749687; CAH18472.1; -; mRNA.
DR EMBL; CH471126; EAW57482.1; -; Genomic_DNA.
DR EMBL; BC025404; AAH25404.1; -; mRNA.
DR EMBL; BC069251; AAH69251.1; -; mRNA.
DR EMBL; U68385; AAB19195.1; -; mRNA.
DR CCDS; CCDS33064.1; -. [Q99687-2]
DR CCDS; CCDS46132.1; -. [Q99687-3]
DR CCDS; CCDS74406.1; -. [Q99687-1]
DR RefSeq; NP_001009813.1; NM_001009813.2. [Q99687-3]
DR RefSeq; NP_001287988.1; NM_001301059.1. [Q99687-1]
DR RefSeq; NP_064545.1; NM_020160.2. [Q99687-2]
DR AlphaFoldDB; Q99687; -.
DR SMR; Q99687; -.
DR BioGRID; 121245; 26.
DR IntAct; Q99687; 24.
DR iPTMnet; Q99687; -.
DR PhosphoSitePlus; Q99687; -.
DR BioMuta; MEIS3; -.
DR DMDM; 59803105; -.
DR jPOST; Q99687; -.
DR MassIVE; Q99687; -.
DR MaxQB; Q99687; -.
DR PeptideAtlas; Q99687; -.
DR PRIDE; Q99687; -.
DR ProteomicsDB; 78398; -. [Q99687-1]
DR ProteomicsDB; 78399; -. [Q99687-2]
DR ProteomicsDB; 78400; -. [Q99687-3]
DR Antibodypedia; 31559; 430 antibodies from 25 providers.
DR DNASU; 56917; -.
DR Ensembl; ENST00000441740.6; ENSP00000388667.2; ENSG00000105419.18. [Q99687-3]
DR Ensembl; ENST00000558555.6; ENSP00000454073.1; ENSG00000105419.18. [Q99687-1]
DR Ensembl; ENST00000559524.5; ENSP00000452854.1; ENSG00000105419.18. [Q99687-2]
DR Ensembl; ENST00000561293.5; ENSP00000453307.1; ENSG00000105419.18. [Q99687-2]
DR GeneID; 56917; -.
DR KEGG; hsa:56917; -.
DR MANE-Select; ENST00000558555.6; ENSP00000454073.1; NM_001301059.2; NP_001287988.1.
DR UCSC; uc002pgs.5; human. [Q99687-1]
DR CTD; 56917; -.
DR GeneCards; MEIS3; -.
DR HGNC; HGNC:29537; MEIS3.
DR HPA; ENSG00000105419; Tissue enhanced (brain, endometrium).
DR MIM; 619443; gene.
DR neXtProt; NX_Q99687; -.
DR OpenTargets; ENSG00000105419; -.
DR PharmGKB; PA30742; -.
DR VEuPathDB; HostDB:ENSG00000105419; -.
DR GeneTree; ENSGT00940000161057; -.
DR HOGENOM; CLU_023139_1_1_1; -.
DR InParanoid; Q99687; -.
DR OMA; HSERPLF; -.
DR OrthoDB; 1126341at2759; -.
DR PhylomeDB; Q99687; -.
DR TreeFam; TF318093; -.
DR PathwayCommons; Q99687; -.
DR SignaLink; Q99687; -.
DR BioGRID-ORCS; 56917; 29 hits in 1091 CRISPR screens.
DR ChiTaRS; MEIS3; human.
DR GenomeRNAi; 56917; -.
DR Pharos; Q99687; Tbio.
DR PRO; PR:Q99687; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q99687; protein.
DR Bgee; ENSG00000105419; Expressed in body of uterus and 104 other tissues.
DR ExpressionAtlas; Q99687; baseline and differential.
DR Genevisible; Q99687; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IBA:GO_Central.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..375
FT /note="Homeobox protein Meis3"
FT /id="PRO_0000049110"
FT DOMAIN 96..179
FT /note="MEIS N-terminal"
FT /evidence="ECO:0000255"
FT DNA_BIND 262..324
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 25..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 150..166
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_012892"
FT VAR_SEQ 286
FT /note="S -> SRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCWWLQ
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_012893"
FT CONFLICT 1..4
FT /note="MARR -> LASQ (in Ref. 2; CAB95771/CAH18472)"
FT /evidence="ECO:0000305"
FT CONFLICT 168..169
FT /note="KM -> RP (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="M -> I (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="D -> V (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="R -> P (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="Q -> E (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 356..360
FT /note="VRPPG -> FRAPA (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 364..370
FT /note="MSLNLEG -> DEFGTRKE (in Ref. 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 41115 MW; 7C29818279800786 CRC64;
MARRYDELPH YPGIVDGPAA LASFPETVPA VPGPYGPHRP PQPLPPGLDS DGLKREKDEI
YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPPGGDVC SSDSFNEDIA AFAKQVRSER
PLFSSNPELD NLMIQAIQVL RFHLLELEKV HDLCDNFCHR YITCLKGKMP IDLVIEDRDG
GCREDFEDYP ASCPSLPDQN NMWIRDHEDS GSVHLGTPGP SSGGLASQSG DNSSDQGDGL
DTSVASPSSG GEDEDLDQER RRNKKRGIFP KVATNIMRAW LFQHLSHPYP SEEQKKQLAQ
DTGLTILQVN NWFINARRRI VQPMIDQSNR TGQGAAFSPE GQPIGGYTET QPHVAVRPPG
SVGMSLNLEG EWHYL
