位置:首页 > 蛋白库 > MEIS3_MOUSE
MEIS3_MOUSE
ID   MEIS3_MOUSE             Reviewed;         378 AA.
AC   P97368; Q149R5; Q99L81;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Homeobox protein Meis3;
DE   AltName: Full=Meis1-related protein 2;
GN   Name=Meis3; Synonyms=Mrg2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=Swiss Webster;
RX   PubMed=8950991;
RA   Nakamura T., Jenkins N.A., Copeland N.G.;
RT   "Identification of a new family of Pbx-related homeobox genes.";
RL   Oncogene 13:2235-2242(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=21059917; DOI=10.1073/pnas.1007001107;
RA   Liu J., Wang Y., Birnbaum M.J., Stoffers D.A.;
RT   "Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell
RT   survival via PDK1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:20494-20499(2010).
CC   -!- FUNCTION: Transcriptional regulator which directly modulates PDPK1
CC       expression, thus promoting survival of pancreatic beta-cells. Also
CC       regulates expression of NDFIP1, BNIP3, and CCNG1.
CC       {ECO:0000269|PubMed:21059917}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21059917}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P97368-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P97368-2; Sequence=VSP_012894;
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in the brain. Significant
CC       expression also observed in the heart, spleen and lung. Expressed in
CC       pancreatic islets (beta-cells and non-beta-cells) (PubMed:21059917).
CC       {ECO:0000269|PubMed:21059917}.
CC   -!- DEVELOPMENTAL STAGE: Not expressed until 11 days in embryonic
CC       development.
CC   -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U57344; AAC52949.1; -; mRNA.
DR   EMBL; CH466654; EDL42107.1; -; Genomic_DNA.
DR   EMBL; BC003762; AAH03762.1; -; mRNA.
DR   EMBL; BC117532; AAI17533.1; -; mRNA.
DR   CCDS; CCDS39782.1; -. [P97368-1]
DR   CCDS; CCDS71892.1; -. [P97368-2]
DR   RefSeq; NP_001264917.1; NM_001277988.2. [P97368-2]
DR   RefSeq; NP_001264918.1; NM_001277989.2. [P97368-2]
DR   RefSeq; NP_001289401.1; NM_001302472.1. [P97368-1]
DR   RefSeq; NP_032653.2; NM_008627.4. [P97368-1]
DR   RefSeq; XP_006539666.1; XM_006539603.3. [P97368-1]
DR   AlphaFoldDB; P97368; -.
DR   SMR; P97368; -.
DR   BioGRID; 201488; 2.
DR   IntAct; P97368; 3.
DR   STRING; 10090.ENSMUSP00000002495; -.
DR   PhosphoSitePlus; P97368; -.
DR   MaxQB; P97368; -.
DR   PaxDb; P97368; -.
DR   PRIDE; P97368; -.
DR   Antibodypedia; 31559; 430 antibodies from 25 providers.
DR   DNASU; 17537; -.
DR   Ensembl; ENSMUST00000002495; ENSMUSP00000002495; ENSMUSG00000041420. [P97368-1]
DR   Ensembl; ENSMUST00000176506; ENSMUSP00000134918; ENSMUSG00000041420. [P97368-2]
DR   GeneID; 17537; -.
DR   KEGG; mmu:17537; -.
DR   UCSC; uc009fha.3; mouse. [P97368-1]
DR   UCSC; uc009fhd.3; mouse. [P97368-2]
DR   CTD; 56917; -.
DR   MGI; MGI:108519; Meis3.
DR   VEuPathDB; HostDB:ENSMUSG00000041420; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   GeneTree; ENSGT00940000161057; -.
DR   HOGENOM; CLU_023139_1_1_1; -.
DR   InParanoid; P97368; -.
DR   OMA; HSERPLF; -.
DR   OrthoDB; 1126341at2759; -.
DR   PhylomeDB; P97368; -.
DR   TreeFam; TF318093; -.
DR   BioGRID-ORCS; 17537; 1 hit in 74 CRISPR screens.
DR   ChiTaRS; Meis3; mouse.
DR   PRO; PR:P97368; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P97368; protein.
DR   Bgee; ENSMUSG00000041420; Expressed in cortical plate and 180 other tissues.
DR   ExpressionAtlas; P97368; baseline and differential.
DR   Genevisible; P97368; MM.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR   GO; GO:0001654; P:eye development; IBA:GO_Central.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IMP:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR032453; PKNOX/Meis_N.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF16493; Meis_PKNOX_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..378
FT                   /note="Homeobox protein Meis3"
FT                   /id="PRO_0000049111"
FT   DOMAIN          99..182
FT                   /note="MEIS N-terminal"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        265..327
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          24..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         152..168
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012894"
FT   CONFLICT        18
FT                   /note="T -> M (in Ref. 3; AAH03762)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        193
FT                   /note="A -> T (in Ref. 1; AAC52949)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   378 AA;  41726 MW;  3D0CB5FD586741B4 CRC64;
     MARRYDELRH YPGITEHTTA LASFSEAAPS VPRAPGPYTP HRPPQLQAPG LDSDSLKREK
     DDIYGHPLFP LLALVFEKCE LATCSPRDGA SAGLGSPPGG DVCSSDSFNE DIAAFAKQIR
     SERPLFSSNP ELDNLMVQAI QVLRFHLLEL EKVHDLCDNF CHRYITCLKG KMPIDLVIED
     RDGSCREDLE DYAASCPSLP DQNTTWIRDH EDSGSVHLGT PGPSSGGLAS QSGDNSSDQG
     DGLDTSVASP SSAGEDEDLD LERRRNKKRG IFPKVATNIM RAWLFQHLSH PYPSEEQKKQ
     LAQDTGLTIL QVNNWFINAR RRIVQPMIDQ SNRTGQGASF NPEGQPMAGF TETQPQVTVR
     TPGSMGMNLN LEGEWHYL
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024