MEIS3_XENTR
ID MEIS3_XENTR Reviewed; 453 AA.
AC Q6DIF3; Q28IX3;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Homeobox protein meis3 {ECO:0000312|EMBL:AAH75589.1};
GN Name=meis3 {ECO:0000312|EMBL:AAH75589.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAH75589.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:AAH75589.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH75589.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-453.
RC TISSUE=Neurula {ECO:0000312|EMBL:AAH75589.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: A caudalizing protein which is required to pattern the
CC anterior/posterior (A/P) axis during central nervous system (CNS)
CC formation. Inhibits anterior neural expression and acts as a
CC transcriptional activator to induce posterior neural gene expression.
CC Maintains a proper A/P balance required for hindbrain formation by
CC activating the FGF/MAPK pathway, which modulates the planar cell
CC polarity (PCP) pathway. Interacts with retinoid signaling during
CC hindbrain patterning (By similarity). {ECO:0000250|UniProtKB:Q5U4X3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000255}.
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DR EMBL; BC075589; AAH75589.1; -; mRNA.
DR EMBL; CR760178; CAJ82625.1; -; mRNA.
DR RefSeq; NP_001006782.1; NM_001006781.1.
DR AlphaFoldDB; Q6DIF3; -.
DR SMR; Q6DIF3; -.
DR STRING; 8364.ENSXETP00000006113; -.
DR PaxDb; Q6DIF3; -.
DR DNASU; 448474; -.
DR Ensembl; ENSXETT00000006113; ENSXETP00000006113; ENSXETG00000002807.
DR GeneID; 448474; -.
DR KEGG; xtr:448474; -.
DR CTD; 56917; -.
DR Xenbase; XB-GENE-485337; meis3.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_023139_1_1_1; -.
DR InParanoid; Q6DIF3; -.
DR OMA; HSERPLF; -.
DR OrthoDB; 1126341at2759; -.
DR TreeFam; TF318093; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000002807; Expressed in neurula embryo and 33 other tissues.
DR ExpressionAtlas; Q6DIF3; baseline.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IBA:GO_Central.
DR GO; GO:0030902; P:hindbrain development; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..453
FT /note="Homeobox protein meis3"
FT /id="PRO_0000355573"
FT DOMAIN 102..185
FT /note="MEIS N-terminal"
FT /evidence="ECO:0000255"
FT DNA_BIND 267..329
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 33..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 427
FT /note="A -> T (in Ref. 1; AAH75589)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 453 AA; 49102 MW; 43111753ABE44458 CRC64;
MAQRYDEMVH YPGLDGMPLA GFGDAHTGRA LQHHSLSQSA PYGSTGAAHR VPMPPGMGSN
DGLKREKDEI YGHPLFPLLA LVFEKCELAT CSPRDNSGSF PGGDVCSSDS FNEDIAVFAK
QVRTEKPLFS SNPELDSLMI QAIQVLRFHL LELEKVHDLC DNFCHRYITC LKGKMPIDLV
IDDRDGSSKS DLEDFTGSCT SLSDQNNSWI RDHDETGSTH SGTPGPSSGG LASQSGDNSS
EQGDCMDNSV ASPSTGDDDD LDRDKKRNKK RGIFPKVATN IMRAWLFQHL SHPYPSEEQK
KQLAQDTGLT ILQVNNWFIN ARRRIVQPMI DQSNRTGQGG APYSPDGQNM GGYVMDGQQH
MGIRPPGFQG IPGDYTAAPS TMPMGFPPAG YTPAIPPHSA GLRHGPSLHS YLPGHPHHAS
MILPAGASPH HLVSAQSPAD ALLNGQNIDI HAH
