ID   MEJUC_BACIU             Reviewed;          30 AA.
AC   C0HL39;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Mejucin {ECO:0000303|Ref.1};
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, MASS
RP   SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   STRAIN=SN7 {ECO:0000303|Ref.1};
RX   DOI=10.1016/j.lwt.2017.08.044;
RA   Lee S.E., Chang H.C.;
RT   "Purification and characterization of Mejucin, a new bacteriocin produced
RT   by Bacillus subtilis SN7.";
RL   LWT Food Sci. Technol. 15:0-0(2017).
CC   -!- FUNCTION: Bacteriocin that inhibits the growth of several Gram-positive
CC       bacteria, especially the food-borne pathogens L.monocytogenes, B.cereus
CC       strain ATCC 11778, B.cereus strain ATCC 21366, B.cereus strain ATCC
CC       10876 and B.cereus strain ATCC 14579. Likely to act by disrupting the
CC       pathogen membrane resulting in leakage of intracellular constituents.
CC       Does not inhibit the growth of Gram-negative bacteria.
CC       {ECO:0000269|Ref.1}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Active from pH 3.0 and pH 9.0. {ECO:0000269|Ref.1};
CC       Temperature dependence:
CC         Thermostable, retains activity after heating at 50 degrees Celsius
CC         for 24 hours. Activity decreases over 70 degrees Celsius.
CC         {ECO:0000269|Ref.1};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=3401.56; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the bacteriocin class V family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; C0HL39; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR021539; Subtilosin_A.
DR   Pfam; PF11420; Subtilosin_A; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Secreted.
FT   PEPTIDE         1..30
FT                   /note="Mejucin"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000442141"
SQ   SEQUENCE   30 AA;  2884 MW;  E3007A0AD2B774AF CRC64;
     LGPQLNKGCA TCSIGAACLV DGPIPDEIAG