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ARHGA_MOUSE
ID   ARHGA_MOUSE             Reviewed;        1345 AA.
AC   Q8C033; Q5DU38; Q80VH8; Q8BW76; Q922S7;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Rho guanine nucleotide exchange factor 10;
GN   Name=Arhgef10; Synonyms=Kiaa0294;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Olfactory bulb, and Oviduct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Fetal brain;
RA   Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA   Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT   complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT   screening of terminal sequences of cDNA clones randomly sampled from size-
RT   fractionated libraries.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND ALTERNATIVE
RP   SPLICING.
RX   PubMed=14508709; DOI=10.1086/378159;
RA   Verhoeven K., De Jonghe P., Van de Putte T., Nelis E., Zwijsen A.,
RA   Verpoorten N., De Vriendt E., Jacobs A., Van Gerwen V., Francis A.,
RA   Ceuterick C., Huylebroeck D., Timmerman V.;
RT   "Slowed conduction and thin myelination of peripheral nerves associated
RT   with mutant rho Guanine-nucleotide exchange factor 10.";
RL   Am. J. Hum. Genet. 73:926-932(2003).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157 AND SER-1262, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Lung, Pancreas, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May play a role in developmental myelination of peripheral
CC       nerves. {ECO:0000269|PubMed:14508709}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1;
CC         IsoId=Q8C033-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8C033-2; Sequence=VSP_010707;
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC       {ECO:0000269|PubMed:14508709}.
CC   -!- DEVELOPMENTAL STAGE: Found in the neuroepithelium of the meninges at
CC       8.5 dpc, and in the roof plate of the rhombencephalon at 9.5 dpc. In
CC       12.5 dpc embryos, it is ubiquitously expressed, with a pronounced
CC       expression in the neuroepithelium of brain vesicles, the neural tube,
CC       the ganglia and the neural layer of the retina.
CC       {ECO:0000269|PubMed:14508709}.
CC   -!- PTM: Methylated at Gln-1314 by N6AMT1. {ECO:0000250|UniProtKB:O15013}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH59212.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH66074.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC27875.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAD90400.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK032452; BAC27875.1; ALT_INIT; mRNA.
DR   EMBL; AK054038; BAC35629.2; -; mRNA.
DR   EMBL; AK220332; BAD90400.1; ALT_INIT; mRNA.
DR   EMBL; BC006842; AAH06842.1; -; mRNA.
DR   EMBL; BC047430; AAH47430.1; -; mRNA.
DR   EMBL; BC059212; AAH59212.1; ALT_INIT; mRNA.
DR   EMBL; BC066074; AAH66074.1; ALT_INIT; mRNA.
DR   CCDS; CCDS40240.1; -. [Q8C033-1]
DR   CCDS; CCDS40241.1; -. [Q8C033-2]
DR   RefSeq; NP_001032825.1; NM_001037736.2. [Q8C033-2]
DR   RefSeq; NP_766339.2; NM_172751.3. [Q8C033-1]
DR   AlphaFoldDB; Q8C033; -.
DR   SMR; Q8C033; -.
DR   BioGRID; 231493; 10.
DR   STRING; 10090.ENSMUSP00000081225; -.
DR   iPTMnet; Q8C033; -.
DR   PhosphoSitePlus; Q8C033; -.
DR   jPOST; Q8C033; -.
DR   MaxQB; Q8C033; -.
DR   PaxDb; Q8C033; -.
DR   PRIDE; Q8C033; -.
DR   ProteomicsDB; 277283; -. [Q8C033-1]
DR   ProteomicsDB; 277284; -. [Q8C033-2]
DR   Antibodypedia; 8026; 167 antibodies from 31 providers.
DR   DNASU; 234094; -.
DR   Ensembl; ENSMUST00000084207; ENSMUSP00000081225; ENSMUSG00000071176. [Q8C033-1]
DR   Ensembl; ENSMUST00000110800; ENSMUSP00000106424; ENSMUSG00000071176. [Q8C033-2]
DR   GeneID; 234094; -.
DR   KEGG; mmu:234094; -.
DR   UCSC; uc009kzg.2; mouse. [Q8C033-1]
DR   UCSC; uc009kzh.2; mouse. [Q8C033-2]
DR   CTD; 9639; -.
DR   MGI; MGI:2444453; Arhgef10.
DR   VEuPathDB; HostDB:ENSMUSG00000071176; -.
DR   eggNOG; KOG3522; Eukaryota.
DR   GeneTree; ENSGT00940000153798; -.
DR   InParanoid; Q8C033; -.
DR   OMA; EYGNNEG; -.
DR   OrthoDB; 67600at2759; -.
DR   PhylomeDB; Q8C033; -.
DR   TreeFam; TF331430; -.
DR   Reactome; R-MMU-193648; NRAGE signals death through JNK.
DR   Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR   Reactome; R-MMU-8980692; RHOA GTPase cycle.
DR   Reactome; R-MMU-9013026; RHOB GTPase cycle.
DR   Reactome; R-MMU-9013106; RHOC GTPase cycle.
DR   Reactome; R-MMU-9013148; CDC42 GTPase cycle.
DR   Reactome; R-MMU-9013149; RAC1 GTPase cycle.
DR   BioGRID-ORCS; 234094; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Arhgef10; mouse.
DR   PRO; PR:Q8C033; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q8C033; protein.
DR   Bgee; ENSMUSG00000071176; Expressed in sciatic nerve and 227 other tissues.
DR   ExpressionAtlas; Q8C033; baseline and differential.
DR   Genevisible; Q8C033; MM.
DR   GO; GO:0005813; C:centrosome; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:MGI.
DR   GO; GO:0019894; F:kinesin binding; ISO:MGI.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; ISO:MGI.
DR   GO; GO:0051298; P:centrosome duplication; ISO:MGI.
DR   GO; GO:0090307; P:mitotic spindle assembly; ISO:MGI.
DR   GO; GO:0022011; P:myelination in peripheral nervous system; ISO:MGI.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; ISO:MGI.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR030632; ARHGEF10.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; PTHR12877; 1.
DR   PANTHER; PTHR12877:SF14; PTHR12877:SF14; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Guanine-nucleotide releasing factor;
KW   Methylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..1345
FT                   /note="Rho guanine nucleotide exchange factor 10"
FT                   /id="PRO_0000080927"
FT   DOMAIN          397..584
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          158..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          207..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1202..1237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1253..1306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          307..335
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        36..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1202..1224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1253..1277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         157
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         355
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O15013"
FT   MOD_RES         1262
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         1314
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000250|UniProtKB:O15013"
FT   VAR_SEQ         283..321
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT                   /id="VSP_010707"
FT   CONFLICT        184
FT                   /note="Missing (in Ref. 1; BAC35629)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        196
FT                   /note="R -> Q (in Ref. 1; BAC27875)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        207
FT                   /note="M -> I (in Ref. 2; BAD90400)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        348
FT                   /note="G -> R (in Ref. 2; BAD90400)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        528
FT                   /note="D -> Y (in Ref. 1; BAC27875)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        581
FT                   /note="L -> R (in Ref. 1; BAC35629)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1332
FT                   /note="V -> F (in Ref. 3; AAH06842)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1345 AA;  147946 MW;  8583299B5A4C5835 CRC64;
     MEQGEASPPV PAEHEAKCDT SNNEEEGELF DFDSGDEVPE ADRQVPSADD RTRGAEAGGA
     DENTCPAGNG TGAEPAPEAE PAKLVVPTKV NPYSVIDITP LQEDQPSSPD ANTEEEGVGL
     RVPSGYSVPV PCGYAVPSNL PLLLPAYSSP VIIRAESVEE EEAAETVGDG QCNSLSSEDL
     PHSSEQGSQE GSALARWAAD PANTAWMENP EEAIYDDVPR ENSDSEPDEM IYDDVENGEE
     GGNSSPEYGW SSSEFESYEE PSDSEGKNGI PRSFLRSSHK KQLSHDLTRF KAHCEEKMRG
     LVASTVGAME IQQAKQRQER KMQKLMKAAK EGTKDGLEKT KAAVKRGGSF IRTRSLVSQD
     HRCYFEEEQN LFIDVDCKHP EAVLTPMPEG LSQQQVVRRY ILGSIVESEK NYVDALRRIL
     EQYEKPLSEM EPRLLSDRKL RMVFYRVKEI LQCHSMFQIA LASRVSEWDV VETIGDVFVA
     SFSKSMVLDA YSEYVNNFST AVAVLKKTCA TKPAFLEFLK LSQDSSPDRV TLHSLMMRPI
     QRFPQFILLL QDMLKNTAKG HPDRLPLQMA LTELETLAEK LNERKRDADQ RCEIKQIAKA
     INERYLNKLL SSGNRYLVRS DDVIETVYND RGEIVKTKQR RIFMLNDVLM CATASSRNSH
     ESHAVMSQRY LLKWSVPLGH VDVIQYNGGS GAGEHCRHHA AHSPESLAVV ANAKPHKVYM
     GPGQLYQDLQ NLLHDLNVVG QISQLIGNLR GSYQNLNQSV AHDWTSGLQR LILRKEDAIR
     AADRCRIQLQ LPGKQDKSGR PTFFTAVFNT LTPAIKESWV SSLQMAKLAL EEENHMGWFC
     VDDDGNLAKK ETHPLLVGHM PVMVAKQPEF KIECAAYNPE PYLSNESQPA SPSTARGFLW
     IGSCSNQMGQ VAIVSFQGSN PKVIECFNVE SRILCMVYIP AEESKPQETT ETKDPEATAS
     RAPHVPTICL GTEEGSISIY KSSQGCKKVR LQHFYAPDKS TVMSLACSPQ GLYAGLVNGS
     VASYTKAPDG SWNSEPQQVI KLGVLPVRSL LLVEGALWAA SGGQVFMASV ETHTIENQLE
     AHQDEGMVIS HMAVAGVGIW IAFTSGSTLR LFHTETLKHL QDVNIDAPVH SMLPGHQRLS
     VTSLLVCHGL LMVGTSLGVV VALPVPRLQG IPKVTGRGMV SYHAHNGPVK FIVSATAFQN
     KDRARDSPRS GSELQDEDPK DLLCSEEGPS CPGQPDTYTS VWLGDSLGLP TQKNDLSSSS
     GSLNLSHGSS SLEHRSVDSS LCDLLRDPSA SPRSRPQGSR RARASSALVV CGGQGHRRVH
     RKARQPSQED LVSSVMVWQI PLLGM
 
 
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