ID   MELR_ECOL6              Reviewed;         302 AA.
AC   P0ACH9; P10411;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Melibiose operon regulatory protein;
GN   Name=melR; OrderedLocusNames=c5123;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Transcription activator for the expression of the melAB
CC       operon. MelR binds at two sites located upstream of the melAB
CC       transcription site (By similarity). {ECO:0000250}.
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DR   EMBL; AE014075; AAN83547.1; -; Genomic_DNA.
DR   RefSeq; WP_001090758.1; NC_004431.1.
DR   AlphaFoldDB; P0ACH9; -.
DR   SMR; P0ACH9; -.
DR   STRING; 199310.c5123; -.
DR   EnsemblBacteria; AAN83547; AAN83547; c5123.
DR   GeneID; 66671971; -.
DR   KEGG; ecc:c5123; -.
DR   eggNOG; COG2169; Bacteria.
DR   HOGENOM; CLU_000445_88_9_6; -.
DR   OMA; MCLFWGG; -.
DR   BioCyc; ECOL199310:C5123-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..302
FT                   /note="Melibiose operon regulatory protein"
FT                   /id="PRO_0000194538"
FT   DOMAIN          194..292
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        211..232
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        259..282
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   302 AA;  34928 MW;  2D9BC3069AB05029 CRC64;
     MNTDTFMCSS DEKQTRSPLS LYSEYQRMEI EFRAPHIMPT SHWHGQVEVN VPFDGDVEYL
     INNEKVNINQ GHITLFWACT PHQLTDTGTC QSMAIFNLPM HLFLSWPLDK DLINHVTHGM
     VIKSLATQQL SPFEVRRWQQ ELNSPNEQIR QLAIDEIGLM LKRFSLSGWE PILVNKTSRT
     HKNSVSRHAQ FYVSQMLGFI AENYDQALTI NDVAEHVKLN ANYAMGIFQR VMQLTMKQYI
     TAMRINHVRA LLSDTDKSIL DIALTAGFRS SSRFYSTFGK YVGMSPQQYR KLSQQRRQTF
     PG