ID   MELT_CAEBR              Reviewed;         867 AA.
AC   Q61QK6; A8X3Z9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein melted homolog;
GN   ORFNames=CBG06982;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- DOMAIN: The PH domain is required for membrane targeting.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MELT/VEPH family. {ECO:0000305}.
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DR   EMBL; HE600960; CAP27359.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q61QK6; -.
DR   STRING; 6238.CBG06982; -.
DR   PRIDE; Q61QK6; -.
DR   EnsemblMetazoa; CBG06982.1; CBG06982.1; WBGene00029160.
DR   WormBase; CBG06982; CBP31805; WBGene00029160; -.
DR   eggNOG; KOG3723; Eukaryota.
DR   HOGENOM; CLU_010394_0_0_1; -.
DR   InParanoid; Q61QK6; -.
DR   OMA; VYPKQPD; -.
DR   OrthoDB; 139521at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0010314; F:phosphatidylinositol-5-phosphate binding; IBA:GO_Central.
DR   GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039888; Melted-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21630; PTHR21630; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..867
FT                   /note="Protein melted homolog"
FT                   /id="PRO_0000297959"
FT   DOMAIN          753..860
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          480..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   867 AA;  97661 MW;  79918FE8B9E5D288 CRC64;
     MHYLLSRLLH QRQLNASAQL FNVSHYDVIT DMSNTFTCLK EIINDPTYPF NKVDQSVVEI
     VIARLTAAIR ETGSIESYAA ELVDVLDEVL KHPMTTLNEK SRDVDSPHCK IASDLLSSLF
     LHYGKKSVMT LTIPVALKCL NSENAELVKN TTSYISLAAI HNGKSLSSHA LQIITKVVKG
     NYSLIRVLPH IYQDNKEPFH AQLSQLIDLL QNQEVDCSEK LSLLQLASMV ANTKPEVLIP
     YLPRFDVYLL SPQLSTALLN IYMSLISQNR TKALSQFLPT LKLAAQSNEF VNNRTTICKI
     IANIGRVSST LASEAVDELV LMARHNLAEP QLLQSVLNEI EAIGSMYPTS LRRHVAFFQT
     LPSSRTIERI LGHLNLNNEN IPLEVKKQST ESLLSKNSKV FGNLITSGGR TVFEVCESPT
     VELCELDRNT HSLAMQYQNN RSSGSLSRRS HASIAHSLGA GTHGPYSDIN ESRELSMISM
     PSSSRTNVHL SQAASSSRGH SLPQTFSPQA MTQIQMGKDG RVRPVAGGRR PVQWPAGSTE
     TTFPAHLGPV TTSKMCALNE EDEKWINSDR NDVVYKFVEH RKNKIRRYIG EVNTRFPIPV
     QCTVEGSKSS KHRMVIHFSC QTRSSPCCVF TKEYLFAFKT KYPAFWLHFM FLQMECSAIT
     QFGEVAGKDS QQYQTLEHCW KCLPSSTTKN VLFDTMITAA FPNSKDQDKL IKELDEAGFF
     AYFTMDSSNN MWNCISCTNP EKVKYFVEEG GVEKVLEGQL KEKKGRWRFL KRWNTKYFTL
     SSAALNYSTQ HMPTDSRALL PSIDLRSIRS VRSLGRGKKA RKSLRKAFEI FTADNTSMIL
     KAKDEKNAEE WLHCLQIAMA HARRELS