ID   MELT_CAEEL              Reviewed;         871 AA.
AC   O17237;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 3.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Protein melted homolog;
GN   ORFNames=K10B4.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- DOMAIN: The PH domain is required for membrane targeting.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MELT/VEPH family. {ECO:0000305}.
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DR   EMBL; FO080912; CCD67734.1; -; Genomic_DNA.
DR   RefSeq; NP_493664.2; NM_061263.2.
DR   AlphaFoldDB; O17237; -.
DR   STRING; 6239.K10B4.3; -.
DR   EPD; O17237; -.
DR   PaxDb; O17237; -.
DR   PeptideAtlas; O17237; -.
DR   EnsemblMetazoa; K10B4.3.1; K10B4.3.1; WBGene00019615.
DR   GeneID; 173397; -.
DR   KEGG; cel:CELE_K10B4.3; -.
DR   UCSC; K10B4.3; c. elegans.
DR   CTD; 173397; -.
DR   WormBase; K10B4.3; CE35995; WBGene00019615; -.
DR   eggNOG; KOG3723; Eukaryota.
DR   GeneTree; ENSGT00390000018660; -.
DR   HOGENOM; CLU_010394_0_0_1; -.
DR   InParanoid; O17237; -.
DR   OMA; VYPKQPD; -.
DR   OrthoDB; 139521at2759; -.
DR   PhylomeDB; O17237; -.
DR   PRO; PR:O17237; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00019615; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0010314; F:phosphatidylinositol-5-phosphate binding; IBA:GO_Central.
DR   GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039888; Melted-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21630; PTHR21630; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..871
FT                   /note="Protein melted homolog"
FT                   /id="PRO_0000297960"
FT   DOMAIN          757..864
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ   SEQUENCE   871 AA;  97889 MW;  6B01D17599B366EA CRC64;
     MHFLLSRLLH HRQLNVSAQL FNVSHYDVIT DMSNTFTCLK EILNAPSYPS NKVDQSVVEI
     VVARLTAAIR ETGSIESYAA ELVDVLDEVL RHPMTTLNEK CQDVDSPHCK IASDLLSSLF
     LHYGNKPVMT LTIPVALKCL NSENGELVKN TTSYISLAAI HNGKSLSSHA LQIISNVVRG
     NYSLIRVLPH IYPDNKEPFH AQLSQLIDLL QNTEVDCSEK LSLLQLSSMV ANTKPDVLIP
     FLPRFDVYLL SPQMSTALLN IYMSLISQNR TKSLSQFLPT LKLAAQSNEF INNRTTICKI
     IANIGRVSSP LASEAVDELV LMARNNSSDQ QILQTVLNEI DAIGSIHPTS LRRHVSFFQT
     LPTSRIIERI LAHLNPNNSE NIMSYDIKEQ STESLLSKNS KVFGNLITSG GRTVFEVCDS
     PTVELCELDR NTHSLAMQYQ NNRSSGSLSR RSHASIAHSL GAGTHGPYSD INESRELSMI
     SMPSSSRTNV LLAQPTSSST SRIQTLPHAF APQAMTQIQM GKDGRVRPVG GGRRPVQWPA
     GSTETTFPAH LGPITTSKMC ALNEEDEKWI NNDRNDVVYK FVEHRKNKIR RYIGEVNARF
     PVPVQCTVEG SKNSKHRMVI HFSCQTRSSP CCVFTKEYLF AFKTKYPAFW LHFMFLQMEC
     SAITQFGEVV GKDSQQYQTL EHCWKCLPSS ITKSVPFDTM ITAAFPNSKD QNKLIKELDE
     AGFFACFTMD STNNMWNCIS CTNPEKVKYF VEEGGAEKVL EGQLKEKKGR WRFLKRWNTK
     YFTLSSAALN YSTQHMPTDS RALLPSIDLR SIRSVRSLGR GKKARKSLRK AFEIFTADNT
     SMILKAKDEK NAEEWLHCLQ IAMAHARREL A