MEM12_ARATH
ID MEM12_ARATH Reviewed; 219 AA.
AC Q9FK28;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Membrin-12;
DE Short=AtMEMB12;
DE AltName: Full=Golgi SNAP receptor complex member 2-2;
GN Name=MEMB12; OrderedLocusNames=At5g50440; ORFNames=MXI22.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Involved in transport of proteins from the cis/medial-Golgi
CC to the trans-Golgi network. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-
CC pass type IV membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GOSR2 family. {ECO:0000305}.
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DR EMBL; AB012248; BAB09463.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95946.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68268.1; -; Genomic_DNA.
DR EMBL; BT004999; AAO50532.1; -; mRNA.
DR RefSeq; NP_001330036.1; NM_001344893.1.
DR RefSeq; NP_199855.1; NM_124426.5.
DR AlphaFoldDB; Q9FK28; -.
DR SMR; Q9FK28; -.
DR BioGRID; 20358; 24.
DR IntAct; Q9FK28; 24.
DR STRING; 3702.AT5G50440.1; -.
DR iPTMnet; Q9FK28; -.
DR PaxDb; Q9FK28; -.
DR PRIDE; Q9FK28; -.
DR ProteomicsDB; 228860; -.
DR EnsemblPlants; AT5G50440.1; AT5G50440.1; AT5G50440.
DR EnsemblPlants; AT5G50440.2; AT5G50440.2; AT5G50440.
DR GeneID; 835112; -.
DR Gramene; AT5G50440.1; AT5G50440.1; AT5G50440.
DR Gramene; AT5G50440.2; AT5G50440.2; AT5G50440.
DR KEGG; ath:AT5G50440; -.
DR Araport; AT5G50440; -.
DR TAIR; locus:2177512; AT5G50440.
DR eggNOG; KOG3251; Eukaryota.
DR HOGENOM; CLU_083740_1_0_1; -.
DR InParanoid; Q9FK28; -.
DR OMA; CLIFMFC; -.
DR OrthoDB; 1139640at2759; -.
DR PhylomeDB; Q9FK28; -.
DR PRO; PR:Q9FK28; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FK28; baseline and differential.
DR Genevisible; Q9FK28; AT.
DR GO; GO:0005801; C:cis-Golgi network; IDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0045088; P:regulation of innate immune response; IMP:TAIR.
DR GO; GO:0050708; P:regulation of protein secretion; IMP:TAIR.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR027027; GOSR2/Membrin/Bos1.
DR PIRSF; PIRSF028865; Membrin-2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9SJL6"
FT CHAIN 2..219
FT /note="Membrin-12"
FT /id="PRO_0000212555"
FT TOPO_DOM 2..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..215
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..219
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9SJL6"
SQ SEQUENCE 219 AA; 25105 MW; 9885F002AF89B4EC CRC64;
MASGTVGGLS EVYSSAKRIL LRARNGIEKL ERFDSDPTDL ASSVKRDITE VQSLCSNMDG
LWRSIPVKSQ RDLWRRKSEQ VGEEAEYLNQ SLEKYMWRNQ RKMLEAKERA DLLGRGSGEG
AHILQIFDEE AQGMNSVKNS KRMLEDSFQS GVAILSKYAE QRDRLKSAQR KALDVLNTVG
LSNSVLRLIE RRNRVDTWIK YAGMIATLVI LYLFIRWTR
