ID   MEMO1_BOVIN             Reviewed;         285 AA.
AC   Q2HJH7;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Protein MEMO1;
DE   AltName: Full=Mediator of ErbB2-driven cell motility 1;
DE            Short=Memo-1;
GN   Name=MEMO1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May control cell migration by relaying extracellular
CC       chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2
CC       signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important
CC       role in ERBB2-dependent stabilization of microtubules at the cell
CC       cortex. It controls the localization of APC and CLASP2 to the cell
CC       membrane, via the regulation of GSK3B activity. In turn, membrane-bound
CC       APC allows the localization of the MACF1 to the cell membrane, which is
CC       required for microtubule capture and stabilization (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ERBB2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MEMO1 family. {ECO:0000305}.
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DR   EMBL; BC105373; AAI05374.1; -; mRNA.
DR   RefSeq; NP_001069863.1; NM_001076395.1.
DR   AlphaFoldDB; Q2HJH7; -.
DR   SMR; Q2HJH7; -.
DR   STRING; 9913.ENSBTAP00000010168; -.
DR   PaxDb; Q2HJH7; -.
DR   PRIDE; Q2HJH7; -.
DR   GeneID; 615803; -.
DR   KEGG; bta:615803; -.
DR   CTD; 7795; -.
DR   eggNOG; KOG3086; Eukaryota.
DR   InParanoid; Q2HJH7; -.
DR   OrthoDB; 1057950at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
DR   CDD; cd07361; MEMO_like; 1.
DR   HAMAP; MF_00055; MEMO1; 1.
DR   InterPro; IPR002737; MEMO1_fam.
DR   PANTHER; PTHR11060; PTHR11060; 1.
DR   Pfam; PF01875; Memo; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..285
FT                   /note="Protein MEMO1"
FT                   /id="PRO_0000260508"
FT   MOD_RES         210
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91VH6"
SQ   SEQUENCE   285 AA;  32525 MW;  8EFB1B439A07B62E CRC64;
     MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA
     HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE
     RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLAEP
     SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH
     NTICGRHPIG VLLNAITELQ KNGMNMSFSF FQQASWRRRM GAAAV