ID   MEMO1_CAEEL             Reviewed;         350 AA.
AC   Q22915; Q8MPV4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-APR-2003, sequence version 3.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Protein memo-1 homolog {ECO:0000250|UniProtKB:Q9Y316};
DE   AltName: Full=Mediator of ErbB2-driven cell motility 1 homolog {ECO:0000250|UniProtKB:Q9Y316};
DE            Short=Mediator of cell motility 1 homolog {ECO:0000312|WormBase:C37C3.8b};
GN   Name=memo-1 {ECO:0000303|PubMed:28085666, ECO:0000312|WormBase:C37C3.8b};
GN   Synonyms=tag-253 {ECO:0000312|WormBase:C37C3.8b};
GN   ORFNames=C37C3.8 {ECO:0000312|WormBase:C37C3.8b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, INTERACTION WITH RHO-1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=28085666; DOI=10.7554/elife.19493;
RA   Ewald C.Y., Hourihan J.M., Bland M.S., Obieglo C., Katic I.,
RA   Moronetti Mazzeo L.E., Alcedo J., Blackwell T.K., Hynes N.E.;
RT   "NADPH oxidase-mediated redox signaling promotes oxidative stress
RT   resistance and longevity through memo-1 in C. elegans.";
RL   Elife 6:0-0(2017).
CC   -!- FUNCTION: Plays a role in the oxidative stress response and the
CC       maintenance of longevity by regulating the interaction between GTPase
CC       rho-1 and oxidase bli-3 (PubMed:28085666). In turn, this serves to
CC       modulate bli-3 activity and the control of reactive oxygen species
CC       production (PubMed:28085666). May control cell migration by relaying
CC       extracellular chemotactic signals to the microtubule cytoskeleton (By
CC       similarity). {ECO:0000250|UniProtKB:Q9Y316,
CC       ECO:0000269|PubMed:28085666}.
CC   -!- SUBUNIT: Interacts with rho-1. {ECO:0000269|PubMed:28085666}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b {ECO:0000312|WormBase:C37C3.8b};
CC         IsoId=Q22915-1; Sequence=Displayed;
CC       Name=a {ECO:0000312|WormBase:C37C3.8a};
CC         IsoId=Q22915-2; Sequence=VSP_007326;
CC   -!- TISSUE SPECIFICITY: Expressed in neuronal and non-neuronal cells in the
CC       head and tail, pharyngeal cells, spermatheca, distal tip cells, anchor
CC       cell and the intestine. {ECO:0000269|PubMed:28085666}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from embryogenesis to adulthood.
CC       {ECO:0000269|PubMed:28085666}.
CC   -!- DISRUPTION PHENOTYPE: 7-38% increase in lifespan compared to wild-type
CC       animals. Increased nuclear accumulation of the transcription factor
CC       skn-1. Increased resistance to oxidative stress as indicated by an
CC       increase in the expression of genes related to the oxidative stress
CC       response and activation of the p38 MAPK pathway. Increased reactive
CC       oxygen species production. Knockout with bli-3 RNAi rescues the
CC       enhanced longevity and increased reactive oxygen species production
CC       defects. Knockout with rho-1 RNAi suppresses reactive oxygen species
CC       induction and longevity in the memo-1 mutant. Double RNAi mediated
CC       knockdown with bli-3 suppresses the nuclear localization of skn-1 in
CC       the memo-1 single mutant. Double RNAi-mediated knockdown with rho-1
CC       eliminates the resistance to oxidative stress in the memo-1 single
CC       mutant. {ECO:0000269|PubMed:28085666}.
CC   -!- SIMILARITY: Belongs to the MEMO1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FO080808; CCD66949.1; -; Genomic_DNA.
DR   EMBL; FO080808; CCD66950.1; -; Genomic_DNA.
DR   PIR; T34398; T34398.
DR   RefSeq; NP_741570.2; NM_171486.5.
DR   RefSeq; NP_741571.1; NM_171487.3.
DR   AlphaFoldDB; Q22915; -.
DR   SMR; Q22915; -.
DR   BioGRID; 44206; 4.
DR   STRING; 6239.C37C3.8b; -.
DR   EPD; Q22915; -.
DR   PaxDb; Q22915; -.
DR   PeptideAtlas; Q22915; -.
DR   PRIDE; Q22915; -.
DR   EnsemblMetazoa; C37C3.8a.1; C37C3.8a.1; WBGene00016500. [Q22915-2]
DR   EnsemblMetazoa; C37C3.8a.2; C37C3.8a.2; WBGene00016500. [Q22915-2]
DR   EnsemblMetazoa; C37C3.8a.3; C37C3.8a.3; WBGene00016500. [Q22915-2]
DR   EnsemblMetazoa; C37C3.8a.4; C37C3.8a.4; WBGene00016500. [Q22915-2]
DR   EnsemblMetazoa; C37C3.8a.5; C37C3.8a.5; WBGene00016500. [Q22915-2]
DR   EnsemblMetazoa; C37C3.8a.6; C37C3.8a.6; WBGene00016500. [Q22915-2]
DR   EnsemblMetazoa; C37C3.8b.1; C37C3.8b.1; WBGene00016500. [Q22915-1]
DR   UCSC; C37C3.8a.1; c. elegans. [Q22915-1]
DR   WormBase; C37C3.8a; CE06933; WBGene00016500; memo-1. [Q22915-2]
DR   WormBase; C37C3.8b; CE30736; WBGene00016500; memo-1. [Q22915-1]
DR   eggNOG; KOG3086; Eukaryota.
DR   GeneTree; ENSGT00390000006408; -.
DR   InParanoid; Q22915; -.
DR   OMA; EQEAQYG; -.
DR   PhylomeDB; Q22915; -.
DR   Reactome; R-CEL-6785631; ERBB2 Regulates Cell Motility.
DR   PRO; PR:Q22915; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00016500; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q22915; baseline and differential.
DR   CDD; cd07361; MEMO_like; 1.
DR   HAMAP; MF_00055; MEMO1; 1.
DR   InterPro; IPR002737; MEMO1_fam.
DR   PANTHER; PTHR11060; PTHR11060; 1.
DR   Pfam; PF01875; Memo; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..350
FT                   /note="Protein memo-1 homolog"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000134396"
FT   VAR_SEQ         1..48
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_007326"
SQ   SEQUENCE   350 AA;  39723 MW;  AF3D5095144098E1 CRC64;
     MSTWRASLGN TILVFCLKVF QNSRALFLRT FGLPFARYLN FILPSEFKMS LNGFGEHTRS
     ASHAGSWYNA NQRDLDRQLT KWLDNAGPRI GTARALISPH AGYSYCGETA AYAFKQVVSS
     AVERVFILGP SHVVALNGCA ITTCSKYRTP LGDLIVDHKI NEELRATRHF DLMDRRDEES
     EHSIEMQLPF IAKVMGSKRY TIVPVLVGSL PGSRQQTYGN IFAHYMEDPR NLFVISSDFC
     HWGERFSFSP YDRHSSIPIY EQITNMDKQG MSAIETLNPA AFNDYLKKTQ NTICGRNPIL
     IMLQAAEHFR ISNNHTHEFR FLHYTQSNKV RSSVDSSVSY ASGVLFVHPN