ID   MEMO1_MACFA             Reviewed;         297 AA.
AC   Q4R6D9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Protein MEMO1;
DE   AltName: Full=Mediator of ErbB2-driven cell motility 1;
DE            Short=Memo-1;
GN   Name=MEMO1; ORFNames=QtsA-18196;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May control cell migration by relaying extracellular
CC       chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2
CC       signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important
CC       role in ERBB2-dependent stabilization of microtubules at the cell
CC       cortex. It controls the localization of APC and CLASP2 to the cell
CC       membrane, via the regulation of GSK3B activity. In turn, membrane-bound
CC       APC allows the localization of the MACF1 to the cell membrane, which is
CC       required for microtubule capture and stabilization (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ERBB2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MEMO1 family. {ECO:0000305}.
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DR   EMBL; AB169245; BAE01336.1; -; mRNA.
DR   RefSeq; NP_001271481.1; NM_001284552.1.
DR   AlphaFoldDB; Q4R6D9; -.
DR   SMR; Q4R6D9; -.
DR   STRING; 9541.XP_005576235.1; -.
DR   GeneID; 102146322; -.
DR   CTD; 7795; -.
DR   VEuPathDB; HostDB:ENSMFAG00000046335; -.
DR   eggNOG; KOG3086; Eukaryota.
DR   OMA; EQEAQYG; -.
DR   OrthoDB; 1057950at2759; -.
DR   Proteomes; UP000233100; Chromosome 13.
DR   GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
DR   CDD; cd07361; MEMO_like; 1.
DR   HAMAP; MF_00055; MEMO1; 1.
DR   InterPro; IPR002737; MEMO1_fam.
DR   PANTHER; PTHR11060; PTHR11060; 1.
DR   Pfam; PF01875; Memo; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Protein MEMO1"
FT                   /id="PRO_0000260509"
FT   MOD_RES         210
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91VH6"
SQ   SEQUENCE   297 AA;  33733 MW;  E315FD5587776211 CRC64;
     MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA
     HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE
     RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLADP
     SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH
     NTICGRHPIG VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH