ID   MEMO1_MOUSE             Reviewed;         297 AA.
AC   Q91VH6;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Protein MEMO1;
DE   AltName: Full=Mediator of ErbB2-driven cell motility 1;
DE            Short=Memo-1;
GN   Name=Memo1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA   Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA   Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT   "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT   chromosome 21 transcription map.";
RL   Genomics 78:46-54(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-210, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Mast cell;
RX   PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
RA   Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA   Kawakami T., Salomon A.R.;
RT   "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT   signaling.";
RL   J. Immunol. 179:5864-5876(2007).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May control cell migration by relaying extracellular
CC       chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2
CC       signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important
CC       role in ERBB2-dependent stabilization of microtubules at the cell
CC       cortex. It controls the localization of APC and CLASP2 to the cell
CC       membrane, via the regulation of GSK3B activity. In turn, membrane-bound
CC       APC allows the localization of the MACF1 to the cell membrane, which is
CC       required for microtubule capture and stabilization (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ERBB2 phosphorylated on 'Tyr-1249'.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MEMO1 family. {ECO:0000305}.
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DR   EMBL; AF363447; AAL34463.1; -; mRNA.
DR   EMBL; BC013819; AAH13819.1; -; mRNA.
DR   CCDS; CCDS28969.1; -.
DR   RefSeq; NP_598532.1; NM_133771.2.
DR   RefSeq; XP_006525172.1; XM_006525109.3.
DR   AlphaFoldDB; Q91VH6; -.
DR   SMR; Q91VH6; -.
DR   BioGRID; 218379; 5.
DR   STRING; 10090.ENSMUSP00000077553; -.
DR   iPTMnet; Q91VH6; -.
DR   PhosphoSitePlus; Q91VH6; -.
DR   EPD; Q91VH6; -.
DR   jPOST; Q91VH6; -.
DR   MaxQB; Q91VH6; -.
DR   PaxDb; Q91VH6; -.
DR   PeptideAtlas; Q91VH6; -.
DR   PRIDE; Q91VH6; -.
DR   ProteomicsDB; 295883; -.
DR   Antibodypedia; 47374; 167 antibodies from 26 providers.
DR   Ensembl; ENSMUST00000233514; ENSMUSP00000156607; ENSMUSG00000058704.
DR   GeneID; 76890; -.
DR   KEGG; mmu:76890; -.
DR   UCSC; uc012axb.1; mouse.
DR   CTD; 7795; -.
DR   MGI; MGI:1924140; Memo1.
DR   VEuPathDB; HostDB:ENSMUSG00000058704; -.
DR   eggNOG; KOG3086; Eukaryota.
DR   GeneTree; ENSGT00390000006408; -.
DR   HOGENOM; CLU_038085_0_1_1; -.
DR   InParanoid; Q91VH6; -.
DR   OMA; EQEAQYG; -.
DR   OrthoDB; 1057950at2759; -.
DR   PhylomeDB; Q91VH6; -.
DR   TreeFam; TF300014; -.
DR   Reactome; R-MMU-6785631; ERBB2 Regulates Cell Motility.
DR   BioGRID-ORCS; 76890; 6 hits in 71 CRISPR screens.
DR   ChiTaRS; Memo1; mouse.
DR   PRO; PR:Q91VH6; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q91VH6; protein.
DR   Bgee; ENSMUSG00000058704; Expressed in spermatocyte and 273 other tissues.
DR   ExpressionAtlas; Q91VH6; baseline and differential.
DR   Genevisible; Q91VH6; MM.
DR   GO; GO:0042277; F:peptide binding; ISO:MGI.
DR   GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
DR   CDD; cd07361; MEMO_like; 1.
DR   HAMAP; MF_00055; MEMO1; 1.
DR   InterPro; IPR002737; MEMO1_fam.
DR   PANTHER; PTHR11060; PTHR11060; 1.
DR   Pfam; PF01875; Memo; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Protein MEMO1"
FT                   /id="PRO_0000134395"
FT   MOD_RES         210
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0007744|PubMed:17947660"
SQ   SEQUENCE   297 AA;  33692 MW;  C3599434A6CFD33A CRC64;
     MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA
     HAYKQVDPSV TRRIFILGPS HHVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE
     RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLADP
     SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH
     NTICGRHPIG VLLNAITELQ KNGMNMSFSF LNYAQSSQCR SWQDSSVSYA AGALTVH