ID   MEMO1_RAT               Reviewed;         297 AA.
AC   Q4QQR9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein MEMO1;
DE   AltName: Full=Mediator of ErbB2-driven cell motility 1;
DE            Short=Memo-1;
GN   Name=Memo1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May control cell migration by relaying extracellular
CC       chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2
CC       signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important
CC       role in ERBB2-dependent stabilization of microtubules at the cell
CC       cortex. It controls the localization of APC and CLASP2 to the cell
CC       membrane, via the regulation of GSK3B activity. In turn, membrane-bound
CC       APC allows the localization of the MACF1 to the cell membrane, which is
CC       required for microtubule capture and stabilization (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ERBB2 phosphorylated on 'Tyr-1250'.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MEMO1 family. {ECO:0000305}.
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DR   EMBL; BC098061; AAH98061.1; -; mRNA.
DR   RefSeq; NP_001025088.1; NM_001029917.1.
DR   AlphaFoldDB; Q4QQR9; -.
DR   SMR; Q4QQR9; -.
DR   IntAct; Q4QQR9; 9.
DR   STRING; 10116.ENSRNOP00000008687; -.
DR   jPOST; Q4QQR9; -.
DR   PaxDb; Q4QQR9; -.
DR   PRIDE; Q4QQR9; -.
DR   Ensembl; ENSRNOT00000008687; ENSRNOP00000008687; ENSRNOG00000006340.
DR   GeneID; 298787; -.
DR   KEGG; rno:298787; -.
DR   UCSC; RGD:1309929; rat.
DR   CTD; 7795; -.
DR   RGD; 1309929; Memo1.
DR   eggNOG; KOG3086; Eukaryota.
DR   GeneTree; ENSGT00390000006408; -.
DR   InParanoid; Q4QQR9; -.
DR   OrthoDB; 1057950at2759; -.
DR   PhylomeDB; Q4QQR9; -.
DR   Reactome; R-RNO-6785631; ERBB2 Regulates Cell Motility.
DR   PRO; PR:Q4QQR9; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
DR   CDD; cd07361; MEMO_like; 1.
DR   HAMAP; MF_00055; MEMO1; 1.
DR   InterPro; IPR002737; MEMO1_fam.
DR   PANTHER; PTHR11060; PTHR11060; 1.
DR   Pfam; PF01875; Memo; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Protein MEMO1"
FT                   /id="PRO_0000260510"
FT   MOD_RES         210
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91VH6"
SQ   SEQUENCE   297 AA;  33679 MW;  F6CFCD4569799211 CRC64;
     MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA
     HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE
     RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLADP
     SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH
     NTICGRHPIG VLLNAITELQ KSGMNMSFSF LNYAQSSQCR SWQDSSVSYA AGALTVH