ARHGH_HUMAN
ID ARHGH_HUMAN Reviewed; 2063 AA.
AC Q96PE2; B2RP20; Q86XU2; Q8N2S0; Q9Y4G3;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Rho guanine nucleotide exchange factor 17;
DE AltName: Full=164 kDa Rho-specific guanine-nucleotide exchange factor;
DE Short=p164-RhoGEF;
DE Short=p164RhoGEF;
DE AltName: Full=Tumor endothelial marker 4;
GN Name=ARHGEF17; Synonyms=KIAA0337, TEM4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11559528;
RA Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W.,
RA St Croix B.;
RT "Cell surface tumor endothelial markers are conserved in mice and humans.";
RL Cancer Res. 61:6649-6655(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401.
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 455-2063.
RC TISSUE=Brain;
RX PubMed=9205841; DOI=10.1093/dnares/4.2.141;
RA Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. VII. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 4:141-150(1997).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12071859; DOI=10.1042/bj20020654;
RA Ruemenapp U., Freichel-Blomquist A., Wittinghofer B., Jakobs K.H.,
RA Wieland T.;
RT "A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF)
RT without a pleckstrin homology domain.";
RL Biochem. J. 366:721-728(2002).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410; SER-420; SER-735 AND
RP SER-914, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142 AND SER-546, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA
CC GTPases. {ECO:0000269|PubMed:12071859}.
CC -!- INTERACTION:
CC Q96PE2; P32242: OTX1; NbExp=3; IntAct=EBI-7543347, EBI-740446;
CC -!- TISSUE SPECIFICITY: Highly expressed in the heart.
CC {ECO:0000269|PubMed:12071859}.
CC -!- WEB RESOURCE: Name=Undiagnosed Disease Network; Note=ARHGEF17;
CC URL="https://undiagnosed.hms.harvard.edu/updates/genes-of-interest/arhgef17-gene/";
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DR EMBL; AF378754; AAL11991.1; -; mRNA.
DR EMBL; CH471076; EAW74891.1; -; Genomic_DNA.
DR EMBL; BC050031; AAH50031.1; -; mRNA.
DR EMBL; BC137228; AAI37229.1; -; mRNA.
DR EMBL; AK074500; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AB002335; BAA20795.2; -; mRNA.
DR CCDS; CCDS8221.1; -.
DR RefSeq; NP_055601.2; NM_014786.3.
DR AlphaFoldDB; Q96PE2; -.
DR SMR; Q96PE2; -.
DR BioGRID; 115166; 48.
DR IntAct; Q96PE2; 30.
DR MINT; Q96PE2; -.
DR STRING; 9606.ENSP00000263674; -.
DR iPTMnet; Q96PE2; -.
DR PhosphoSitePlus; Q96PE2; -.
DR BioMuta; ARHGEF17; -.
DR DMDM; 74724250; -.
DR EPD; Q96PE2; -.
DR jPOST; Q96PE2; -.
DR MassIVE; Q96PE2; -.
DR MaxQB; Q96PE2; -.
DR PaxDb; Q96PE2; -.
DR PeptideAtlas; Q96PE2; -.
DR PRIDE; Q96PE2; -.
DR ProteomicsDB; 77677; -.
DR Antibodypedia; 947; 74 antibodies from 27 providers.
DR DNASU; 9828; -.
DR Ensembl; ENST00000263674.4; ENSP00000263674.3; ENSG00000110237.5.
DR GeneID; 9828; -.
DR KEGG; hsa:9828; -.
DR MANE-Select; ENST00000263674.4; ENSP00000263674.3; NM_014786.4; NP_055601.2.
DR UCSC; uc001otu.4; human.
DR CTD; 9828; -.
DR DisGeNET; 9828; -.
DR GeneCards; ARHGEF17; -.
DR HGNC; HGNC:21726; ARHGEF17.
DR HPA; ENSG00000110237; Low tissue specificity.
DR neXtProt; NX_Q96PE2; -.
DR OpenTargets; ENSG00000110237; -.
DR PharmGKB; PA134884537; -.
DR VEuPathDB; HostDB:ENSG00000110237; -.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_237760_0_0_1; -.
DR InParanoid; Q96PE2; -.
DR OMA; MGQLEPV; -.
DR OrthoDB; 652460at2759; -.
DR PhylomeDB; Q96PE2; -.
DR TreeFam; TF324157; -.
DR PathwayCommons; Q96PE2; -.
DR Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR Reactome; R-HSA-9013026; RHOB GTPase cycle.
DR Reactome; R-HSA-9013106; RHOC GTPase cycle.
DR SignaLink; Q96PE2; -.
DR SIGNOR; Q96PE2; -.
DR BioGRID-ORCS; 9828; 16 hits in 1070 CRISPR screens.
DR ChiTaRS; ARHGEF17; human.
DR GenomeRNAi; 9828; -.
DR Pharos; Q96PE2; Tbio.
DR PRO; PR:Q96PE2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96PE2; protein.
DR Bgee; ENSG00000110237; Expressed in descending thoracic aorta and 181 other tissues.
DR ExpressionAtlas; Q96PE2; baseline and differential.
DR Genevisible; Q96PE2; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:MGI.
DR GO; GO:0030036; P:actin cytoskeleton organization; IDA:MGI.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR039917; ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; PTHR12877; 1.
DR PANTHER; PTHR12877:SF15; PTHR12877:SF15; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome.
FT CHAIN 1..2063
FT /note="Rho guanine nucleotide exchange factor 17"
FT /id="PRO_0000286589"
FT DOMAIN 1066..1254
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT REGION 22..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1991..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2036..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1581
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1639..1687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2002..2016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2039..2053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 142
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 310
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 383
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 387
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 395
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 410
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 420
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 461
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 546
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 619
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 696
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 699
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 702
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 735
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 914
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 961
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 1002
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT MOD_RES 1331
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U35"
FT VARIANT 450
FT /note="G -> E (in dbSNP:rs3741150)"
FT /id="VAR_032132"
FT VARIANT 1465
FT /note="A -> D (in dbSNP:rs2298808)"
FT /id="VAR_032133"
FT CONFLICT 722
FT /note="L -> F (in Ref. 5; BAA20795)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2063 AA; 221673 MW; 76A53FF6CBF5F5C0 CRC64;
MADGAPRPQL YRSVSFKLLE RWSGGPGLRE EDTDTPGLRR RASCRPTTAA RGQPSRRVSK
LASGPLAAPA QPRPLRSLSP SVRQLSRRFD APRLDDGSAG TRDGGVLPAA AEEAAEGPAR
GAWPSVTEMR KLFGGPGSRR PSADSESPGT PSPDGAAWEP PARESRQPPT PPPRTCFPLA
GLRSARPLTG PETEGRLRRP QQQQERAQRP ADGLHSWHIF SQPQAGARAS CSSSSIAASY
PVSRSRAASS SEEEEEGPPQ LPGAQSPAYH GGHSSGSDDD RDGEGGHRWG GRPGLRPGSS
LLDQDCRPDS DGLNLSSMNS AGVSGSPEPP TSPRAPREEG LREWGSGSPP CVPGPQEGLR
PMSDSVGGAF RVAKVSFPSY LASPAGSRGS SRYSSTETLK DDDLWSSRGS GGWGVYRSPS
FGAGEGLLRS QARTRAKGPG GTSRALRDGG FEPEKSRQRK SLSNPDIASE TLTLLSFLRS
DLSELRVRKP GGSSGDRGSN PLDGRDSPSA GGPVGQLEPI PIPAPASPGT RPTLKDLTAT
LRRAKSFTCS EKPMARRLPR TSALKSSSSE LLLTGPGAEE DPLPLIVQDQ YVQEARQVFE
KIQRMGAQQD DGSDAPPGSP DWAGDVTRGQ RSQEELSGPE SSLTDEGIGA DPEPPVAAFC
GLGTTGMWRP LSSSSAQTNH HGPGTEDSLG GWALVSPETP PTPGALRRRR KVPPSGSGGS
ELSNGEAGEA YRSLSDPIPQ RHRAATSEEP TGFSVDSNLL GSLSPKTGLP ATSAMDEGLT
SGHSDWSVGS EESKGYQEVI QSIVQGPGTL GRVVDDRIAG KAPKKKSLSD PSRRGELAGP
GFEGPGGEPI REVEPMLPPS SSEPILVEQR AEPEEPGATR SRAQSERALP EALPPPATAH
RNFHLDPKLA DILSPRLIRR GSKKRPARSS HQELRRDEGS QDQTGSLSRA RPSSRHVRHA
SVPATFMPIV VPEPPTSVGP PVAVPEPIGF PTRAHPTLQA PSLEDVTKQY MLNLHSGEVP
APVPVDMPCL PLAAPPSAEA KPPEAARPAD EPTPASKCCS KPQVDMRKHV AMTLLDTEQS
YVESLRTLMQ GYMQPLKQPE NSVLCDPSLV DEIFDQIPEL LEHHEQFLEQ VRHCMQTWHA
QQKVGALLVQ SFSKDVLVNI YSAYIDNFLN AKDAVRVAKE ARPAFLKFLE QSMRENKEKQ
ALSDLMIKPV QRIPRYELLV KDLLKHTPED HPDHPLLLEA QRNIKQVAER INKGVRSAEE
AERHARVLQE IEAHIEGMED LQAPLRRFLR QEMVIEVKAI GGKKDRSLFL FTDLIVCTTL
KRKSGSLRRS SMSLYTAASV IDTASKYKML WKLPLEDADI IKGASQATNR ENIQKAISRL
DEDLTTLGQM SKLSESLGFP HQSLDDALRD LSAAMHRDLS EKQALCYALS FPPTKLELCA
TRPEGTDSYI FEFPHPDARL GFEQAFDEAK RKLASSKSCL DPEFLKAIPI MKTRSGMQFS
CAAPTLNSCP EPSPEVWVCN SDGYVGQVCL LSLRAEPDVE ACIAVCSARI LCIGAVPGLQ
PRCHREPPPS LRSPPETAPE PAGPELDVEA AADEEAATLA EPGPQPCLHI SIAGSGLEMT
PGLGEGDPRP ELVPFDSDSD DESSPSPSGT LQSQASRSTI SSSFGNEETP SSKEATAETT
SSEEEQEPGF LPLSGSFGPG GPCGTSPMDG RALRRSSHGS FTRGSLEDLL SVDPEAYQSS
VWLGTEDGCV HVYQSSDSIR DRRNSMKLQH AASVTCILYL NNQVFVSLAN GELVVYQREA
GHFWDPQNFK SVTLGTQGSP ITKMVSVGGR LWCGCQNRVL VLSPDTLQLE HMFYVGQDSS
RCVACMVDSS LGVWVTLKGS AHVCLYHPDT FEQLAEVDVT PPVHRMLAGS DAIIRQHKAA
CLRITALLVC EELLWVGTSA GVVLTMPTSP GTVSCPRAPL SPTGLGQGHT GHVRFLAAVQ
LPDGFNLLCP TPPPPPDTGP EKLPSLEHRD SPWHRGPAPA RPKMLVISGG DGYEDFRLSS
GGGSSSETVG RDDSTNHLLL WRV
