MENA_HAEIN
ID MENA_HAEIN Reviewed; 308 AA.
AC P44739;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=1,4-dihydroxy-2-naphthoate octaprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01937};
DE Short=DHNA-octaprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01937};
DE EC=2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937};
GN Name=menA {ECO:0000255|HAMAP-Rule:MF_01937}; OrderedLocusNames=HI_0509;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to
CC demethylmenaquinone (DMK). {ECO:0000255|HAMAP-Rule:MF_01937}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl
CC diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate;
CC Xref=Rhea:RHEA:26478, Rhea:RHEA-COMP:9563, Rhea:RHEA-COMP:9564,
CC ChEBI:CHEBI:11173, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:55437, ChEBI:CHEBI:58914; EC=2.5.1.74;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01937};
CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis;
CC menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.
CC {ECO:0000255|HAMAP-Rule:MF_01937}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01937}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01937}.
CC -!- SIMILARITY: Belongs to the MenA family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01937}.
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DR EMBL; L42023; AAC22167.1; -; Genomic_DNA.
DR PIR; H64153; H64153.
DR RefSeq; NP_438667.2; NC_000907.1.
DR AlphaFoldDB; P44739; -.
DR SMR; P44739; -.
DR STRING; 71421.HI_0509; -.
DR EnsemblBacteria; AAC22167; AAC22167; HI_0509.
DR KEGG; hin:HI_0509; -.
DR PATRIC; fig|71421.8.peg.528; -.
DR eggNOG; COG1575; Bacteria.
DR HOGENOM; CLU_043611_1_1_6; -.
DR OMA; QWIEGAR; -.
DR PhylomeDB; P44739; -.
DR UniPathway; UPA00079; UER00168.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046428; F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004659; F:prenyltransferase activity; IBA:GO_Central.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IBA:GO_Central.
DR GO; GO:0032194; P:ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; IBA:GO_Central.
DR GO; GO:0042371; P:vitamin K biosynthetic process; IBA:GO_Central.
DR CDD; cd13962; PT_UbiA_UBIAD1; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR HAMAP; MF_01937; MenA_1; 1.
DR InterPro; IPR004657; MenA.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR044878; UbiA_sf.
DR InterPro; IPR026046; UBIAD1.
DR PANTHER; PTHR13929; PTHR13929; 1.
DR Pfam; PF01040; UbiA; 1.
DR PIRSF; PIRSF005355; UBIAD1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Menaquinone biosynthesis;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="1,4-dihydroxy-2-naphthoate octaprenyltransferase"
FT /id="PRO_0000096415"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
SQ SEQUENCE 308 AA; 33346 MW; 7A873AFC8071AF6B CRC64;
MRSKKMINEK LKMWWETARP KTLPLALASI FTGSALGYWA NPQGFNGLVM VLCLLTTILL
QVLSNFANDY GDHQKGSDTE ERIGPLRGIQ KGAISAKELK WGLILMVMAS FLSGSFLIGI
AYENLSDLFA FAGLGILAIV AAITYTVGVK PYGYMGLGDI SVLVFFGLLG VGGTYYLQTH
SIDSHIILPA IGSGLLASAV LNINNLRDIE QDAKAGKNTL AVRLGAYKGR VYHCILLSVA
ALCYLAFAVA TAISWTNYLF VLAMPLLAKH AIFVYCSQQP SELRPILAQM SMISLLINIL
FSLGLLIG
